Associations between pre- and post-natal exposure to phthalate and DINCH metabolites and gut microbiota in one-year old children.

The gut microbiota is a collection of symbiotic microorganisms in the gastrointestinal tract. Its sensitivity to chemicals with widespread exposure, such as phthalates, is little known. We aimed to investigate the impact of perinatal exposure to phthalates on the infant gut microbiota at 12 months of age. Within SEPAGES cohort (Suivi de l'Exposition à la Pollution Atmosphérique durant la Grossesse et Effet sur la Santé), we assessed 13 phthalate metabolites and 2 di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH) metabolites in repeated urine samples collected in pregnant women and their offspring. We obtained stool samples from 356 children at 12 months of age and sequenced the V3-V4 region of the 16S rRNA gene, allowing gut bacterial profiling. We used single-chemical (linear regressions) and mixture (BKMR, Bayesian Kernel Machine Regression) models to examine associations of phthalates and DINCH metabolites, with gut microbiota indices of α-diversity (specific richness and Shannon diversity) and the relative abundances of the most abundant microbiota phyla and genera. After correction for multiple testing, di(2-ethylhexyl) phthalate (ΣDEHP), diethyl phthalate (DEP) and bis(2-propylheptyl) phthalate (DPHP) metabolites 12-month urinary concentrations were associated with higher Shannon α-diversity of the child gut microbiota in single-chemical models. The multiple-chemical model (BKMR) suggested higher α-diversity with exposure to the phthalate mixture at 12 months, driven by the same phthalates. There were no associations between phthalate and DINCH exposure biomarkers at other time points and α-diversity after correction for multiple testing. ΣDEHP metabolites concentration at 12 months was associated with higher Coprococcus genus. Finally, ΣDEHP exposure at 12 months tended to be associated with higher phylum Firmicutes, an association not maintained after correction for multiple testing. Infancy exposure to phthalate might disrupt children's gut microbiota. The observed associations were cross-sectional, so that reverse causality cannot be excluded.

被引量：- 发表：1970

Degradation of 2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol (UV328) in soil by FeS activated persulfate: Kinetics, mechanism, and theoretical calculations.

2-(2H-benzotriazol-2-yl)-4,6-di-tert-pentylphenol (UV328) is a commonly used benzotriazole ultraviolet stabilizers (BUVs) with bioaccumulative properties. Since it's stubbornly degraded in the environment, it poses significant environmental risks in soil. However, the removal of UV328 from soil is challenging, and existing treatment methods have low efficiency. This study focuses on UV328 in soil and proposes an efficient method for its removal using persulfate (PS) activated by iron sulfide (FeS). The research demonstrates that with FeS and PS dosages of 20 and 100 mM respectively, and a soil-to-water ratio of 5:1, 12 h-removal efficiency of UV328 with an initial concentration of 12 mg/kg reaches 93.0%. Furthermore, employing electron paramagnetic resonance spectroscopy and quenching experiments, key reactive oxygen species (ROSs) are identified. SO4•-, •OH, 1O2 and •O2- contribute 31.76%, 28.77%, 26.52% and 12.95%, respectively. Four main reaction pathways of amination, hydroxylation, sulfate substitution, and bond cleavage, are identified with 14 transformation products characterized. Calculated energy profiles based on density functional theory (DFT) identify the most susceptible reaction sites for different ROSs. Five different types of agricultural soils were selected to explore the impact of soil characteristics on UV328 removal. The degradation performance of natural mackinawite demonstrates the effectiveness and accessibility of raw materials. Toxicity assessments of transformation products confirm the environmental friendliness of this system. This study proposes an efficient degradation method for UV328-contaminated soil, providing scientific insights and theoretical guidance for addressing environmental removal of BUVs from soil.

被引量：- 发表：1970

Hydrogeochemical properties, source provenance, distribution, and health risk of high fluoride groundwater: Geochemical control, and source apportionment.

被引量：- 发表：1970

Imposex incidence in gastropod species from the Colombian Caribbean Coast reveals continued and widespread tributyltin contamination after its global ban.

被引量：- 发表：1970

Source identification and human exposure assessment of organophosphate flame retardants and plasticisers in soil and outdoor dust from Nigerian e-waste dismantling and dumpsites.

被引量：- 发表：1970