The Medicine Revolution Through Artificial Intelligence: Ethical Challenges of Machine Learning Algorithms in Decision-Making.

The integration of artificial intelligence (AI) and its autonomous learning processes (or machine learning) in medicine has revolutionized the global health landscape, providing faster and more accurate diagnoses, personalization of medical treatment, and efficient management of clinical information. However, this transformation is not without ethical challenges, which require a comprehensive and responsible approach. There are many fields where AI and medicine intersect, such as health education, patient-doctor interface, data management, diagnosis, intervention, and decision-making processes. For some of these fields, there are some guidelines to regulate them. AI has numerous applications in medicine, including medical imaging analysis, diagnosis, predictive analytics for patient outcomes, drug discovery and development, virtual health assistants, and remote patient monitoring. It is also used in robotic surgery, clinical decision support systems, AI-powered chatbots for triage, administrative workflow automation, and treatment recommendations. Despite numerous applications, there are several problems related to the use of AI identified in the literature in general and in medicine in particular. These problems are data privacy and security, bias and discrimination, lack of transparency (Black Box Problem), integration with existing systems, cost and accessibility disparities, risk of overconfidence in AI, technical limitations, accountability for AI errors, algorithmic interpretability, data standardization issues, unemployment, and challenges in clinical validation. Of the various problems already identified, the most worrying are data bias, the black box phenomenon, questions about data privacy, responsibility for decision-making, security issues for the human species, and technological unemployment. There are still several ethical problems associated with the use of AI autonomous learning algorithms, namely epistemic, normative, and comprehensive ethical problems (overarching). Addressing all these issues is crucial to ensure that the use of AI in healthcare is implemented ethically and responsibly, providing benefits to populations without compromising fundamental values. Ongoing dialogue between healthcare providers and the industry, the establishment of ethical guidelines and regulations, and considering not only current ethical dilemmas but also future perspectives are fundamental points for the application of AI to medical practice. The purpose of this review is to discuss the ethical issues of AI algorithms used mainly in data management, diagnosis, intervention, and decision-making processes.

Marques M ，Almeida A ，Pereira H 《Cureus》

Artificial Intelligence, the Digital Surgeon: Unravelling Its Emerging Footprint in Healthcare - The Narrative Review.

Artificial Intelligence (AI) holds transformative potential for the healthcare industry, offering innovative solutions for diagnosis, treatment planning, and improving patient outcomes. As AI continues to be integrated into healthcare systems, it promises advancements across various domains. This review explores the diverse applications of AI in healthcare, along with the challenges and limitations that need to be addressed. The aim is to provide a comprehensive overview of AI's impact on healthcare and to identify areas for further development and focus. The review discusses the broad range of AI applications in healthcare. In medical imaging and diagnostics, AI enhances the accuracy and efficiency of diagnostic processes, aiding in early disease detection. AI-powered clinical decision support systems assist healthcare professionals in patient management and decision-making. Predictive analytics using AI enables the prediction of patient outcomes and identification of potential health risks. AI-driven robotic systems have revolutionized surgical procedures, improving precision and outcomes. Virtual assistants and chatbots enhance patient interaction and support, providing timely information and assistance. In the pharmaceutical industry, AI accelerates drug discovery and development by identifying potential drug candidates and predicting their efficacy. Additionally, AI improves administrative efficiency and operational workflows in healthcare, streamlining processes and reducing costs. AI-powered remote monitoring and telehealth solutions expand access to healthcare, particularly in underserved areas. Despite the significant promise of AI in healthcare, several challenges persist. Ensuring the reliability and consistency of AI-driven outcomes is crucial. Privacy and security concerns must be navigated carefully, particularly in handling sensitive patient data. Ethical considerations, including bias and fairness in AI algorithms, need to be addressed to prevent unintended consequences. Overcoming these challenges is critical for the ethical and successful integration of AI in healthcare. The integration of AI into healthcare is advancing rapidly, offering substantial benefits in improving patient care and operational efficiency. However, addressing the associated challenges is essential to fully realize the transformative potential of AI in healthcare. Future efforts should focus on enhancing the reliability, transparency, and ethical standards of AI technologies to ensure they contribute positively to global health outcomes.

Shang Z ，Chauhan V ，Devi K ，Patil S ... -  《Journal of Multidisciplinary Healthcare》

Unraveling the Ethical Enigma: Artificial Intelligence in Healthcare.

Jeyaraman M ，Balaji S ，Jeyaraman N ，Yadav S ... -  《Cureus》

Tribulations and future opportunities for artificial intelligence in precision medicine.

Upon a diagnosis, the clinical team faces two main questions: what treatment, and at what dose? Clinical trials' results provide the basis for guidance and support for official protocols that clinicians use to base their decisions. However, individuals do not consistently demonstrate the reported response from relevant clinical trials. The decision complexity increases with combination treatments where drugs administered together can interact with each other, which is often the case. Additionally, the individual's response to the treatment varies with the changes in their condition. In practice, the drug and the dose selection depend significantly on the medical protocol and the medical team's experience. As such, the results are inherently varied and often suboptimal. Big data and Artificial Intelligence (AI) approaches have emerged as excellent decision-making tools, but multiple challenges limit their application. AI is a rapidly evolving and dynamic field with the potential to revolutionize various aspects of human life. AI has become increasingly crucial in drug discovery and development. AI enhances decision-making across different disciplines, such as medicinal chemistry, molecular and cell biology, pharmacology, pathology, and clinical practice. In addition to these, AI contributes to patient population selection and stratification. The need for AI in healthcare is evident as it aids in enhancing data accuracy and ensuring the quality care necessary for effective patient treatment. AI is pivotal in improving success rates in clinical practice. The increasing significance of AI in drug discovery, development, and clinical trials is underscored by many scientific publications. Despite the numerous advantages of AI, such as enhancing and advancing Precision Medicine (PM) and remote patient monitoring, unlocking its full potential in healthcare requires addressing fundamental concerns. These concerns include data quality, the lack of well-annotated large datasets, data privacy and safety issues, biases in AI algorithms, legal and ethical challenges, and obstacles related to cost and implementation. Nevertheless, integrating AI in clinical medicine will improve diagnostic accuracy and treatment outcomes, contribute to more efficient healthcare delivery, reduce costs, and facilitate better patient experiences, making healthcare more sustainable. This article reviews AI applications in drug development and clinical practice, making healthcare more sustainable, and highlights concerns and limitations in applying AI.

Carini C ，Seyhan AA 《Journal of Translational Medicine》

Challenges of artificial intelligence in medicine and dermatology.

Grzybowski A ，Jin K ，Wu H 《-》