Reliability and validity of the Chinese version of the Copenhagen Multi-Centre Psychosocial Infertility-Fertility Problem Stress Scales.

The aim of this study is to introduce the Copenhagen Multi-Centre Psychosocial Infertility (COMPI)-Fertility Problem Stress Scales (COMPI-FPSS) into China and test its applicability in Chinese infertile population. Infertility-related stress not only influences patients' psychological well-being but is also strongly associated with reduced pregnancy rates and poorer assisted conception outcomes, thus warranting focussed attention. The design used in this study is a cross-sectional survey. A total of 418 participants were recruited by convenience sampling from March to July 2022. The data were randomly divided into two parts: one for item analysis and exploratory factor analysis and the other for confirmatory factor analysis and reliability test. The critical ratio and homogeneity test were used to verify the differentiation and homogeneity of the COMPI-FPSS; the construct validity was determined by explanatory and confirmatory factor analyses; Cronbach's α coefficient and Spearman-Brown coefficient were used to assess the reliability; and criterion validity was expressed using correlation coefficients for the Perceived Stress Scale and the Negative Affect Scale as the validity criteria. The revised Chinese version of COMPI-FPSS has 11 items and 2 dimensions (i.e., personal stress domain and social stress domain). Exploratory factor analysis showed that the cumulative variance contribution rate of the two factors was 68.6%, and confirmatory factor analysis indicated that the model fitted well. The score of the COMPI-FPSS was significantly and positively associated with perceived stress and negative affect. The Cronbach's α coefficient of the total scale was 0.905, and the Spearman-Brown coefficient was 0.836, explaining excellent reliability. The revised Chinese version of COMPI-FPSS shows good reliability and validity, and it can be used to evaluate the infertility-related stress of infertile patients in China.

Gao Y ，Wang Q ，Li G ，Zhao X ，Qin R ，Kong L ，Li P ... -  《-》

Erratum: Eyestalk Ablation to Increase Ovarian Maturation in Mud Crabs.

《Jove-Journal of Visualized Experiments》

Translation, Reliability and Validity of the Chinese Version of the Confidence in Dementia Scale for Clinical Nursing: A Cross-Sectional Study.

To translate the 9-item Confidence in Dementia (CODE) scale into Chinese (Confidence in Dementia-Chinese, CODE-C) and evaluate its psychometric properties among clinical nurses. With the rapidly ageing population, an increasing number of patients with dementia will be cared for in hospitals. Clinical nurses' confidence in dementia care is crucial to provide quality care. A reliable and valid assessment tool is urgently needed to measure confidence in dementia and identify educational needs in hospitals. The CODE applies to other societies, and this study aims to standardise this scale for China. This was a cross-sectional study. Following the principles of Brislin bidirectional translation, literal translation, back-translation, expert consultation, cognitive debriefing and preliminary testing were performed, and the CODE-C was preliminarily revised. Internal consistency and test-retest reliabilities with a 2-week interval were tested, and an item analysis was conducted using the Pearson correlation coefficient method. Validity was evaluated, including content, construct, convergent, discriminant and criterion validity. A total of 452 Chinese-speaking nurses from three hospitals in Jinan, China, completed the survey. The scores of each item and the total score of the CODE-C were positively correlated (r = 0.626-0.802, p < 0.05). The difference between the high-score group and the low-score group for each item of the CODE-C was significant (p < 0.05). The Cronbach's α coefficient, Spearman-Brown coefficient and Guttman split-half coefficient of the CODE-C were 0.894, 0.842 and 0.838, respectively, and the test-retest reliability was 0.892. The scale- and item-level content validity indices were both 1.00. The confirmatory factor analysis model only marginally supported the three-factor structure. Positive correlations were noted between the CODE-C and the General Self-Efficacy Scale (r = 0.476, p < 0.01), suggesting acceptable concurrent validity. The CODE-C showed acceptable reliability and validity and can be applied to measure the level of confidence in dementia and the outcome of educational interventions aimed at enhancing dementia care among Chinese clinical nurses. The CODE-C can be used as a valid scale to assess the level of confidence in dementia among clinical nurses and help them recognise and improve their level of dementia care.

Jiang Q ，Li N ，Kong D ，Zhai Y ，Chen H ，Liu J ，Xiao P ，Chen Y ，Pei W ，Song J ... -  《-》

Cross-cultural adaptation and validation of the Chinese version of the PSS-QoL questionnaire.

The quality of life(QoL) of patients with primary Sjögren's syndrome(PSS) is affected by a variety of symptoms, and it is important to comprehensively assess the factors affecting patients' QoL.The PSS-QoL is a specific tool for the assessment of patients' QoL in the PSS. The purpose of this study was to cross-culturally adapt the PSS-QoL for the Chinese language,to establish a QoL assessment tool for PSS patients in Chinese culture and to test the reliability and validity of the PSS-QoL. Our study period was from January 17, 2024 to June 15, 2024. The study was designed as a two-stage observational study. Double forward and backward translations of the PSS-QoL were performed for cultural adaptation to the Chinese language,and the specific steps included forward and backward translations, coordination, expert correspondence, small-sample surveys, and corrections to form the final draft of the Chinese version of the PSS-QoL. From January 29, 2024 to June 15, 2024,for the evaluation of psychometric properties, 135 patients with PSS completed the Chinese version of the PSS-QoL,Short Form-12(SF-12) and EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI).After 2 to 4 weeks,15 patients with PSS completed the Chinese version of the PSS-QoL for the second time.We used SPSS 26.0 software to statistically analyze the data, including item analysis and reliability and validity tests. The Chinese version of the PSS-QoL consists of 25 questions and can be divided into two main categories: physical (discomfort and dryness) and psychosocial. The mean score on the Chinese version of the PSS-QoL was 40.46±15.00. Among the 135 patients with PSS,92.60% were female, the mean (±SD) age was 52.76±12.74 years, and the disease duration was 5 (1.5, 9) years. There was good differentiation between the individual items and the Chinese version of the PSS-QoL,as the decision value of all the items ranged from -3.223 to -12.234 (p < 0.05), the correlation coefficient between the individual items and the whole questionnaire ranged from 0.315 to 0.730 (p < 0.05), the Chinese version of the PSS-QoL had good reliability and validity,as Cronbach's α = 0.886, the Spearman-Brown coefficient was 0.782,the reliability of the individual items was 0.89,and the values of the I-CVI and S-CVI/AVE were all 1, indicating good psychometric properties. The construct validity between the Chinese version of the PSS-QoL and the ESSPRI was excellent (p = 0.506 ~0.687), and that between the PSS-QoL and the SF-12 was good(p = -0.464 ~ -0.673). The Chinese version of the PSS-QoL possesses good reliability and validity, and all the indicies meet the metrics and satisfy the psychometrically acceptable range;therefore, it can be used as a reliable instrument for assessing the QoL of patients with PSS in China.

Zhou Y ，Zhuang L ，He X ，Xu L ，He Q ，Li X ，Ye Y ... -  《PLoS One》

Psychosocial and physical wellbeing in women and male partners undergoing immediate versus postponed modified natural cycle frozen embryo transfer after ovarian stimulation and oocyte pick-up: a sub-study of a randomized controlled trial.

Are there differences in psychosocial and physical wellbeing among women and male partners undergoing modified natural cycle (mNC) frozen embryo transfer (FET) in immediate compared to postponed cycles after ovarian stimulation (OS) and oocyte pick-up (OPU)? Significantly more women in the immediate group reported physical symptoms than women in the postponed group whilst fewer were emotionally affected by waiting time, although the latter difference lost statistical significance after adjustment for multiple testing. Infertility and fertility treatment are known to cause psychosocial distress in women and couples longing for a child. The treatment may be long-term and delayed for various reasons, such as the elective postponement of FET after a fresh transfer without pregnancy or an elective freeze-all cycle, possibly further increasing the level of distress. Sub-study of an ongoing multicentre randomized controlled, non-inferiority trial assessing the optimal timing for mNC-FET treatment after OS and OPU. Participants were randomized 1:1 to mNC-FET in the cycle immediately following OS or mNC-FET in a subsequent cycle. The study is based on data from the first women (N = 300) and male partners (N = 228) invited to answer a self-reported questionnaire assessing psychosocial and physical wellbeing. Data were collected from April 2021 to March 2024. Questionnaires were distributed to all randomized women and their male partners on cycle day 2-5 of mNC-FET cycles and returned before the administration of ovulation trigger. The questionnaire consisted of validated items originating from the Copenhagen Multicentre Psychosocial Infertility-Fertility Problem Stress Scale (COMPI-FPSS) and Marital Benefit Measure (COMPI-MBM). Emotional reactions to waiting time in fertility treatment, mental health, general quality-of-life, and physical symptoms were also assessed. Questionnaire response rates were 90.3% for women and 80.0% for male partners in the immediate group, and 82.3% for women and 57.3% for male partners in the postponed group. Approximately 90% of all women worried to some or a great extent about whether the treatment would be successful. More women in the postponed group reported that they were emotionally affected by the waiting time from OPU to blastocyst transfer to some or to a great extent (57.4% versus 73.9% in the immediate versus postponed group, P = 0.014), but the results were not significant after adjustment for multiple testing (P = 0.125). For male partners, no difference in emotional reactions to waiting time between groups was found. There was no significant difference in total infertility-related stress or symptoms of severe depression between the immediate and the postponed group for women or male partners, but women were generally more distressed than their partners. There was a significantly higher incidence of stomach and/or pelvic pain (24.0% versus 9.4%, adjusted P = 0.013), feeling of being bloated (33.8% versus 15.1%, adjusted P = 0.010) and swollen or tender breasts (24.8% versus 0.9%, P < 0.001) in the immediate group. All items were self-reported. No assessment of psychosocial or physical wellbeing was performed before participant enrolment. The sample size of male partners was relatively small, and female partners were not included in this sub-study due to a very small number of participants in this group. If immediate mNC-FET proves to be effective, physical and emotional factors may play a key role in choosing treatment strategy for the individual patient. This study demonstrated more physical symptoms related to OS in the immediate cycles. The RCT was supported by Rigshospitalet's Research Foundation and an independent research grant from Merck A/S (MS200497_0024). Merck A/S had no role in the design of this study and will not have any role during its execution, analyses, interpretation of data, or decision to submit results. The authors are fully responsible for the content of this manuscript, and the views and opinions described in the publication reflect solely those of the authors. A.P. received grants from Gedeon Richter, Ferring Pharmaceuticals, Merck A/S and Cryos as payment to the institution. A.P. received consulting fees from IBSA, Ferring Pharmaceuticals, Gedeon Richter, Cryos and Merck A/S, and honoraria from Organon, Ferring Pharmaceuticals, Gedeon Richter and Merck A/S. A.P. received support for meeting attendance from Gedeon Richter. M.S. benefitted from a grant from Gedeon Richter. S.B. and C.C. benefitted from a grant from Merck A/S. S.B. is currently employed by Novo Nordisk. N.C.F. received grants from Gedeon Richter, Merck A/S and Cryos as payment to the institution. N.C.F. received consulting fees from Merck A/S and support for meeting attendance from Merck A/S, Ferring Pharmaceuticals, IBSA, and Gedeon Richter. N.C.F. is chair of the steering committee for the guideline groups for The Danish Fertility Society. E.L. received a radiometer contract on blood gas validation as a payment to the institution. E.L. received honoraria from Pfizer and support for meeting attendance from Astella. B.N. received grants from IBSA, Ferring Pharmaceuticals, Merck A/S, and Gedeon Richter as payment to the institution. B.N. received honoraria from Merck A/S and Organon and support for meeting attendance from IBSA and Gedeon Richter. B.N. and L.P. participate in an Advisory Board at Ferring Pharmaceuticals. L.P. received support for meeting attendance from Merck A/S, Ferring Pharmaceuticals, and Gedeon Richter. L.P. declare stocks in Novo Nordisk. ClinicalTrials.gov NCT04748874.

Bergenheim S ，Saupstad M ，Colombo C ，Møller JE ，Bogstad JW ，Freiesleben NC ，Behrendt-Møller I ，Prætorius L ，Oxlund B ，Nøhr B ，Husth M ，Løkkegaard E ，Sopa N ，Pinborg A ，Løssl K ，Schmidt L ... -  《-》