Vitamin D and risk of ankylosing spondylitis: A two-sample mendelian randomization study.

To study whether Vitamin D levels are causally associated with ankylosing spondylitis (AS). Two-sample Mendelian randomization (TSMR) analysis was performed by employing MR-Egger regression, weighted median (WM1), inverse-variance weighted (IVW), and weight mode (WM2) methods. The odds ratio (OR) with 95% confidence intervals (CIs) was used to evaluate this association. The results of IVW show that no causal association between vitamin D and AS (OR = 0.999, 95%CI = 0.997, 1.002, P = 0.724). The MR-Egger regression results show that genetic pleiotropy does not bias the results (intercept = -4.474E-05, SE = 2.830E-05, P = 0.255). The MR-Egger method no supported causal association between vitamin D and AS (OR = 1.000, 95%CI = 0.996, 1.005, P = 0.879). WM1 (OR = 1.002, 95%CI = 0.999, 1.005, P = 0.837) and WM2 (OR = 0.998, 95%CI = 0.996, 1.002, P = 0.910) approach also not found a causal relationship between vitamin D levels and AS. The significant heterogeneity was not observed by Cochran's Q test. The "leave-one-out" analysis also proved lack of a single SNP affected the robustness of our results. Based on our analysis, there is lack of a strong evidence to support a causal inverse association between vitamin D levels and ankylosing spondylitis.

Jiang J ，Shao M ，Wu X 《-》

Ankylosing spondylitis status and risk of secondary systemic amyloidosis: A two-sample mendelian randomization study.

Chen H ，Yu L ，Shao M 《-》

Association between type 1 diabetes mellitus and ankylosing spondylitis: a two-sample Mendelian randomization study.

Zhang J ，Qi J ，Li Y ，Wang J ，Jiang H ，Sun Q ，Gu Q ，Ying Z ... -  《Frontiers in Immunology》

No Evidence of a Genetic Causal Relationship between Ankylosing Spondylitis and Gut Microbiota: A Two-Sample Mendelian Randomization Study.

Yang M ，Wan X ，Zheng H ，Xu K ，Xie J ，Yu H ，Wang J ，Xu P ... -  《Nutrients》

Common mineral nutrients in ankylosing spondylitis: A 2-sample Mendelian randomization study.

The causal relationship between common mineral nutrients and ankylosing spondylitis (AS) has not been studied. So this Mendelian randomization (MR) study aims to investigate the causal association of varying levels of calcium, zinc, copper, and selenium on AS. We selected 4 elements potentially associated with the onset and development of AS as exposure factors, single nucleotide polymorphisms (SNPs) as instrumental variables, and these SNPs are independent of each other(r2  < 0.05) and highly correlated with each of the 4 elements (P < 5 × 10-8 ). The 2-sample MR method takes Inverse-variance weighted (IVW) and MR-Egger as the main method and Simple mode (SM), Weighted median (WM1 ), and Weighted mode (WM2 ) as supplementary methods to evaluate the causal effect of mineral levels on AS. The IVW analysis does not provide convincing evidence to support a causal association between calcium (odds ratio [OR] = 1.000, 95% CI = 0.994, 1.005, P = .875), copper (OR = 1.000, 95% CI = 1.000, 1.001, P = .533) and selenium (OR = 0.999, 95% CI = 0.998, 1.000, P = .229) and AS. The IVW (OR = 1.001, 95% CI = 1.000, 1.002, P = .029) and WM1 (OR = 1.001, 95% CI = 1.000, 1.002, P = .011) results of zinc show that per standard deviation increment in zinc is a suggestive association with risks of AS, and MR-Egger (OR = 1.004, 95% CI = 0.996, 1.013, P = .265) and other supplementary methods indicate that zinc is not causally associated with AS. All MR-Egger intercept parameters and MR Pleiotropy RESidual Sum and Outlier tests demonstrated the absence of horizontal pleiotropy. This study does not provide convincing evidence to support a causal correlation between calcium, zinc, copper, and selenium with AS.

Sun X ，Deng Y ，Ma Y ，Shao M ，Ni M ，Zhang T ，Wang X ，Xu S ，Chen Y ，Xu S ，Pan F ... -  《-》