Associations between immediate postpartum long-acting reversible contraception and short interpregnancy intervals.

We aimed to evaluate the rates of short interpregnancy interval pregnancies and deliveries among women who receive immediate postpartum LARC. We conducted a retrospective cohort study of all women who delivered at Montefiore Medical Center between January 2015 and June 2016 (N = 9561). In this cohort, we identified all repeat deliveries and pregnancies within 18 months of the initial delivery. Using logistic regression models, we compared rates of short interpregnancy interval delivery and pregnancy among recipients of an immediate postpartum IUD, immediate postpartum implant, and no immediate postpartum LARC, adjusting for covariates including patient age, mode of delivery, socioeconomic status, and race. In our cohort, 12.9% of patients received immediate postpartum LARC. The rates of short interpregnancy interval delivery were 3.3% (N = 259/7833) among patients who did not receive immediate postpartum LARC, 1% (N = 6/595) among immediate postpartum IUD recipients, and 0.4% (N = 2/562) among immediate postpartum implant recipients. The rates of short interpregnancy interval pregnancy were 13.8% (N = 1082/7833) among patients who did not receive immediate postpartum LARC, 7.4% (N = 44/595) among immediate postpartum IUD recipients, and 5.2% (N = 29/562) among immediate postpartum implant recipients. Both recipients of immediate postpartum IUDs and immediate postpartum implants had lower rates of short interpregnancy interval delivery and pregnancy compared to patients who did not receive immediate postpartum LARC. This study confirms that women who received immediate postpartum IUDs and implants have lower rates of short interpregnancy interval pregnancies. Making immediate postpartum LARC widely available is a promising public health approach to help women achieve a longer interpregnancy interval.

Wu M ，Eisenberg R ，Negassa A ，Levi E ... -  《-》

Coverage of immediate postpartum long-acting reversible contraception has improved birth intervals for at-risk populations.

In 2012, South Carolina revised the Medicaid policy to cover reimbursement for immediate postpartum long-acting reversible contraception. Immediate postpartum long-acting reversible contraception may improve health outcomes for populations at risk with a subsequent short-interval pregnancy. We examined the impact of the Medicaid policy change on the initiation of long-acting and reversible contraception (immediate postpartum and postpartum) within key populations. We determined whether immediate postpartum long-acting and reversible contraception use varied by adequate prenatal care (>7 visits), metropolitan location, and medical comorbidities. We also tested the association of immediate postpartum and postpartum long-acting, reversible contraception on interpregnancy interval of less than 18 months. We conducted a historical cohort study of live births among Medicaid recipients in South Carolina between 2010 and 2017, 2 years before and 5 years after the policy change. We used birth certificate data linked with Medicaid claims. Our primary outcome was immediate postpartum long-acting and reversible contraception, and our secondary outcome was short interpregnancy interval. We characterize trends in long-acting and reversible contraception use and interpregnancy interval over the study period. We used logistic regression models to test the association of key factors (rural, inadequate prenatal care, and medical comorbidities) with immediate and outpatient postpartum long-acting and reversible contraception following the policy change and to test the association of immediate postpartum and postpartum long-acting and reversible contraception with short interpregnancy interval. Our sample included 187,438 births to 145,973 women. Overall, 44.7% of the sample was white, with a mean age of 25.0 years. A majority of the sample (61.5%) was multiparous and resided in metropolitan areas (79.5%). The odds of receipt of immediate postpartum long-acting and reversible contraception use increased after the policy change (adjusted odds ratio, 1.39, 95% confidence interval, 1.34-1.43). Women with inadequate prenatal care (adjusted odds ratio, 1.50, 95% confidence interval, 1.31-1.71) and medically complex pregnancies had higher odds of receipt of immediate postpartum long-acting and reversible contraception following the policy change (adjusted odds ratio, 1.47, 95% confidence interval, 1.29-1.67) compared with women with adequate prenatal care and normal pregnancies. Women residing in rural areas were less likely to receive immediate postpartum long-acting and reversible contraception (adjusted odds ratio, 0.36, 95% confidence interval, 0.30-0.44) than women in metropolitan areas. Utilization of immediate postpartum long-acting and reversible contraception was associated with a decreased odds of a subsequent short interpregnancy interval (adjusted odds ratio, 0.62, 95% confidence interval, 0.44-0.89). Women at risk of a subsequent pregnancy and complications (inadequate prenatal care and medical comorbidities) are more likely to receive immediate postpartum long-acting and reversible contraception following the policy change. Efforts are needed to improve access in rural areas.

Liberty A ，Yee K ，Darney BG ，Lopez-Defede A ，Rodriguez MI ... -  《-》

Postpartum LARC discontinuation and short interval pregnancies among women with HIV: a retrospective 9-year cohort study in South Carolina.

To evaluate rates of discontinuation and short interval pregnancy among women with HIV who received a postpartum IUD or implant. We conducted a retrospective cohort study of women who had an IUD or implant placed within 3 months postpartum during a 9-year period (1/1/09 to 2/14/18). We assessed the prevalence of discontinuation within 12 months and rates of subsequent delivery within 18 months. We examined differences in these outcomes between women with and without HIV. Of the 794 women who received a long-acting reversible contraception (LARC) within 3 months postpartum, most chose an IUD (85%). Twenty-one percent (165) elected for immediate postpartum placement: 119 IUDs and 46 implants. Women with HIV were more likely to receive an implant (48% vs 13%, p<.0001) and were more likely to have immediate postpartum placement (76% vs 17%, p<.0001). Women with HIV (n=50) were not more likely to remove LARC devices within 12 months of placement (38% vs 36%, p=.9), and they did not experience any short interval pregnancies. Women with HIV in South Carolina were more likely than HIV-negative women to receive immediate postpartum LARC and to receive an implant. They were not more likely to discontinue LARC within 12 months nor experience short interval pregnancies. Further study is needed to evaluate preferences for implants and immediate postpartum insertion among women with HIV.

Lazenby G ，Francis E ，Brzozowski N ，Rucker L ，Dempsey A ... -  《-》

Examining the association between short interpregnancy interval births and the type and timing of postpartum long acting reversible contraception.

To determine whether the type (intrauterine device or implant) or timing (immediately postpartum vs interval) of postpartum long-acting reversible contraception was associated with a reduction in short interpregnancy interval births. We conducted a retrospective cohort study using linked Medicaid claims and birth certificate data from Oregon and South Carolina, 2010 to 2018. Our primary outcome was short interpregnancy interval, defined as repeat pregnancy within 18 months of the index delivery. We determined postpartum contraceptive method and timing of receipt. To assess the association of timing of long acting reversible contraception with short interpregnancy interval, we calculated adjusted probabilities from a logistic regression model incorporating covariate balanced propensity score weights, sociodemographic factors, and clustered at the woman-level. Our study sample included 121,422 births to 97,084 individuals who had more than 1 birth during the study period; 41% had a short interpregnancy interval. A majority of individuals had not received any contraception by 6 months postpartum (68.6%). Overall, 15,477 individuals used long acting reversible contraception postpartum, with the majority receiving interval rather than immediate postpartum long acting reversible contraception (92.9% vs 7.1%). In multivariable analyses, both immediate postpartum (23.0%, 95% CI: 20.5%-25.8%) and interval long acting reversible contraception (15.2%, 95% CI: 14.4%-16.1%) are associated with a lower probability of short interpregnancy interval than short acting methods (42.1%, 95% CI: 41.2%-43.0%). Compared to short-acting methods, receipt of both immediate postpartum and interval long-acting reversible contraception is associated with lower probabilities of a subsequent short interpregnancy interval. All long acting, reversible contraception, whether placed immediately postpartum or on an interval basis, was associated with a significantly lower probability of a short interpregnancy interval than short acting or no contraceptive method.

Rodriguez MI ，Skye M ，Ramanadhan S ，Schrote K ，Darney BG ... -  《-》

Factors associated with short interpregnancy interval in women who plan postpartum LARC: a retrospective study.

Pregnancies conceived after a short interpregnancy interval (IPI), within 18 months of delivery, and unintended pregnancies are both associated with health risks. We studied risk factors for conception after a short IPI among postpartum women who plan long-acting reversible contraception (LARC). A retrospective review of a cohort of women who delivered at University of Illinois Hospital from 2005 to 2010 and were discharged with a plan for interval LARC was performed. Outcomes were (1) attendance at a postpartum visit (PPV), (2) LARC placement (3) and conception after a short IPI. We compared variables using chi-squared test, Student's t tests and multivariable logistic regression. Of 3548 women, 62.0% attended a PPV, 36.5% received LARC and 11.4% conceived after a short IPI. After logistic regression, women who were multiparous [odds ratio (OR) 0.77, 95% confidence interval (CI) 0.65-0.91] or chose a temporary contraceptive "bridge" to LARC (OR 0.74, 95% CI 0.58-0.94) were less likely to attend their PPV. Women who missed their PPV (OR 0.06, 95% CI 0.05-0.08) or chose a bridge (OR 0.66, 95% CI 0.50-0.88) were less likely to receive LARC. Finally, women who did not receive LARC (OR 4.8, 95% CI 3.50-6.70), were multiparous (OR 1.69, 95% CI 1.32-2.15) or teenaged (OR 2.12, 95% CI 1.61-2.79) were more likely to conceive after a short IPI. Women who receive postpartum LARC are less likely to become pregnant after a short IPI. Missing the PPV, multiparity and plan for a contraceptive bridge may all contribute to a patient not receiving planned LARC. Efforts to decrease unintended pregnancy after a short IPI should focus on decreasing barriers to planned postpartum LARC. Provision of temporary bridge contraception until interval LARC may not mitigate the significant barriers associated with interval postpartum placement protocols.

Harney C ，Dude A ，Haider S 《-》