Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production.

Four new triterpene saponins, mandshunosides F-I (1-4), together with five known compounds (5-9), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis products. Bisdesmosidic saponin (3-9) showed modest suppression of NO production with the inhibition ratios in the range of 51.3%- 64.6% at 50 μmol·L-1, whereas monodesmosidic saponins with a free carboxyl group at C-28 (1 and 2) showed potent inhibitory activities with IC50 values being 12.7 and 8.3 μmol·L-1, respectively.

Fu Q ，Yang M ，Ma Y ，Chen J ，Yuan HM ... -  《-》

Cytotoxic triterpene saponins from Clematis mandshurica.

He YX ，Li L ，Zhang K ，Liu ZR ... -  《-》

Triterpene saponins from clematis mandshurica.

Shi S ，Jiang D ，Dong C ，Tu P ... -  《JOURNAL OF NATURAL PRODUCTS》

Triterpene saponins from Clematis chinensis and their potential anti-inflammatory activity.

Fu Q ，Zan K ，Zhao M ，Zhou S ，Shi S ，Jiang Y ，Tu P ... -  《-》

Triterpene saponins from Clematis mandshurica and their antiproliferative activity.

Six new triterpene saponins, clematomandshurica saponins F-K (1-6), together with a known compound (7), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis. Compounds 5-7 exhibited antiproliferative effects against PC-3 human prostate cancer cells with GI50 values of 1.29, 1.50, and 0.71 µM, respectively.

Gong YX ，Hua HM ，Xu YN ，Liu JY ，Yu ZG ，Ma J ，Zhang H ，Jing YK ... -  《-》