Triterpene saponins from Clematis mandshurica and their antiproliferative activity.

Six new triterpene saponins, clematomandshurica saponins F-K (1-6), together with a known compound (7), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis. Compounds 5-7 exhibited antiproliferative effects against PC-3 human prostate cancer cells with GI50 values of 1.29, 1.50, and 0.71 µM, respectively.

Gong YX ，Hua HM ，Xu YN ，Liu JY ，Yu ZG ，Ma J ，Zhang H ，Jing YK ... -  《-》

Cytotoxic triterpene saponins from Clematis mandshurica.

He YX ，Li L ，Zhang K ，Liu ZR ... -  《-》

Triterpene saponins from clematis mandshurica.

Shi S ，Jiang D ，Dong C ，Tu P ... -  《JOURNAL OF NATURAL PRODUCTS》

Triterpenoid saponins from the roots of Clematis argentilucida and their cytotoxic activity.

The reinvestigation of the n-BuOH extract of the roots of Clematis argentilucida led to the isolation of four new oleanane-type triterpenoid saponins, 1-4, four known saponins, 5-8, first isolated from the species, together with ten saponins, 9-18, reported in the preceding papers. The structures of saponins 1-8 were elucidated by extensive spectroscopic analysis and chemical evidences. The cytotoxicity of all the saponins were evaluated against human tumor HL-60, HepG-2, and SGC-7901 cell lines. The monodesmosidic saponins 4, 7, 8, and 14-18 exhibited cytotoxic activity against the three cell lines with IC50 values in the range of 0.87-19.48 µM.

Zhao M ，Ma N ，Qiu F ，Hai WL ，Tang HF ，Zhang Y ，Wen AD ... -  《-》

Three new triterpene saponins from Clematis chinensis.

Fu Q ，Zan K ，Zhao MB ，Zhou SX ，Shi SP ，Jiang Y ，Tu PF ... -  《-》