Association of total zinc, iron, copper and selenium intakes with depression in the US adults.

The aim of present study was to examine the associations of total zinc, iron, copper and selenium intakes from diet and supplements with depression. Cross-sectional study used data from the National Health and Nutrition Examination Survey (NHANES) 2009-2014 in the present study. Logistic regression models and restricted cubic spline models were applied to examine the associations of total zinc, iron, copper and selenium intakes with depression. A total of 14834 adults aged 18 years or older (7399 men and 7435 women) were included in the present study. Total zinc, iron, copper and selenium intakes were inversely associated with depression in unadjusted model and age- and gender-adjusted model. The multivariate adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of depression were 0.68 (0.49-0.94) and 0.46 (0.32-0.67) for the highest versus lowest quartile of copper and selenium intakes, respectively. The inverse associations of depression were statistically significant for the quartile 3 versus lowest quartile of total zinc (OR: 0.70; 95% CI: 0.49-0.99) and iron intake (OR: 0.66 95% CI: 0.50-0.87). Compared to those below the RDA (Recommended Dietary Allowance), participants who met the RDA for zinc (OR: 0.74; 95% CI: 0.56-0.99), copper (OR: 0.68; 95% CI: 0.56-0.82) and selenium (OR: 0.52; 95% CI: 0.39, 0.71) had significantly lower odds of depression. This was a cross-sectional study, limiting causal inferences. Assessment of depression was based on a self- report scale. Total zinc, iron, copper and selenium intakes may be inversely associated with depression.

Li Z ，Wang W ，Xin X ，Song X ，Zhang D ... -  《-》

Association of Zinc, Iron, Copper, and Selenium Intakes with Low Cognitive Performance in Older Adults: A Cross-Sectional Study from National Health and Nutrition Examination Survey (NHANES).

Li S ，Sun W ，Zhang D 《-》

Is selenium intake associated with the presence of depressive symptoms among US adults? Findings from National Health and Nutrition Examination Survey (NHANES) 2011-2014.

This study aimed to examine the cross-sectional association between dietary and serum selenium measures and depressive symptoms among a nationally representative sample of US adults. Dietary selenium intake and serum selenium concentration were evaluated on 7725 adult participants from National Health and Nutrition Examination Survey (NHANES) 2011-2014. Participants' selenium intake, assessed by 24-h recall, was classified based on the recommended dietary allowance (dietary selenium intake ≥ 55 μg/d) and estimated average requirement (dietary selenium intake ≥ 45 μg/d) criteria. Serum selenium and depressive symptoms were assessed using inductively coupled plasma mass spectrometry and a patient health questionnaire or use of an antidepressant, respectively. Univariate and multivariate logistic regression, accounting for the complex survey design of NHANES, were employed to estimate the cross-sectional association between measures of selenium and the presence of depressive symptoms. The median selenium concentration was 193.9 µg/L (interquartile range = 179.3-209.3). Approximately 8% of the participants met the case definition for depressive symptoms. Based on the recommended dietary allowance of selenium, participants not meeting the recommended dietary intake, compared with those meeting the requirement, had higher odds of depressive symptoms (odds ratio [OR] = 1.57, 95% confidence interval [CI]: 1.03-2.38). When analyzing by quintile of dietary selenium intakes, compared with the first quintile, participants in higher quintiles had significantly lower odds of depressive symptoms. However, based on quintiles of serum selenium and using the first quintile as referent category, except for quintile 3, results indicated a higher but not significant association (quintile 2 [OR = 1.08, 95% CI: 0.73-1.61], quintile 4 [OR = 1.17, 95% CI: 0.89-1.55], and quintile 5 [OR = 1.14, 95% CI: 0.83-1.58]). Power analysis indicated sufficient power. Notably, study participants had a very high serum selenium concentration. The findings, although not significant, between serum selenium concentrations and depressive symptoms had a U-shaped association, supported by the current literature. Our study supports an inverse association between participants recommended dietary intake of selenium and depressive symptoms. Although results were not statistically significant for the association by quartile of serum selenium concentrations and depressive symptoms, a U-shaped association was identified.

Ghimire S ，Baral BK ，Feng D ，Sy FS ，Rodriguez R ... -  《-》

Dietary Zinc, Copper, and Selenium Intake and High-Risk Human Papillomavirus Infection among American Women: Data from NHANES 2011-2016.

Xiao D ，Li W ，Zhang WH ，Wen Z ，Dai B ，Mo W ，Qiu S ，Yang L ... -  《-》

The association between intakes of dietary trace minerals and gallstone disease: A cross-sectional study from National Health and Nutrition Examination Survey 2017 to 2018.

The gallstone disease is becoming increasingly prevalent worldwide. Dietary trace minerals have been proven to be closely related to many metabolic diseases, and this study aims to explore the association between intakes of dietary trace minerals (copper, iron, selenium, and zinc) and gallstone disease (GSD). Using the National Health and Nutrition Examination Survey (NHANES) from 2017 to 2018, intakes of dietary trace minerals and GSD data were obtained through a 24-hour recall and diagnostic questionnaire, respectively. Weighted logistic regression models were used to identify the association between intakes of dietary trace minerals and the prevalence of GSD, and the results were presented as odds ratios (OR) and 95% confidence intervals (95% CI). A total of 4077 participants were included in the final analysis, of which 456 participants had GSD and 3621 participants serving as the control group. No significant associations between GSD and intakes of dietary trace minerals (iron, selenium, and zinc) were found. However, after adjusting for all covariates, significant association was demonstrated between dietary copper (Cu) intake and GSD (OR = 0.66, 95% CI = 0.45-0.98). After conducting a weighted quantile logistic regression, a significant negative correlation was also found between dietary Cu intake and highest GSD quartile (Q4) (OR = 0.45, 95% CI = 0.26-0.80). Following the research outlined above, no association was found between intakes of dietary trace minerals (iron, selenium, and zinc) and GSD; however, a linear negative association was identified between dietary Cu intake and GSD.

Yan S ，Yu L ，Fang S ，Gu C ... -  《-》