Chronic lithium treatment diminishes the female advantage in lifespan in Drosophila melanogaster.

Two studies have concluded that lithium exposure extends the lifespan of Caenorhabditis elegans. However, the effect of lithium on another widely used model organism, Drosophila melanogaster, remains unclear. Here, we demonstrate that chronic treatment with a low to moderate dose of lithium chloride does not extend lifespan in D. melanogaster and that the drug abolishes the female lifespan advantage in flies.

Zhu F ，Li Q ，Zhang F ，Sun X ，Cai G ，Zhang W ，Chen X ... -  《-》

Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans.

The pharmacological activation of stress-defense mechanisms is one of the perspective ways to increase human lifespan. The goal of the present study was to study the effects on lifespan of Drosophila melanogaster and Caenorhabditis elegans of two carotenoids: ß-carotene and fucoxanthin, which are bioactive natural substances in human diet. In addition, the effects of carotenoids on the flies survival were studied under stress conditions, including starvation, thermal stress (35°C), oxidative stress (20 mM paraquat), as well as locomotor activity, fecundity, and genes expression level. Our results demonstrated lifespan extension of flies by both carotenoids. However, the positive effects on the lifespan of C. elegans were revealed only for fucoxanthin. In presence of carotenoids decreased flies' fecundity, increased spontaneous locomotor activity and resistance to oxidative stress were detected.

Lashmanova E ，Proshkina E ，Zhikrivetskaya S ，Shevchenko O ，Marusich E ，Leonov S ，Melerzanov A ，Zhavoronkov A ，Moskalev A ... -  《-》

Lutein extends the lifespan of Drosophila melanogaster.

Lutein is one of the major carotenoids in most fruits and vegetables. The effect of lutein on the lifespan of Drosophila melanogaster was investigated. Results revealed that 0.1mg lutein/ml diet could prolong their mean lifespan from 49.0 to 54.6 days. This was consistent with a significant reduction in malonyldialdehyde (MDA) level and increase in antioxidant enzyme activities of the flies fed with lutein-treated diet compared with those fed with basal diet. Paraquat (PQ) and H2O2 treatment tests demonstrated that lutein could prolong the survival time of the flies. Real-time polymerase chain reaction (RT-PCR) analysis indicated the gene expression of superoxide dismutase (SOD; SOD1 and SOD2), and catalase (CAT) in the lutein-treated group was up-regulated relative to that of the control group. It was concluded that the lifespan-prolonging activity of lutein was partially by up-regulation of endogenous antioxidant enzymes.

Zhang Z ，Han S ，Wang H ，Wang T ... -  《-》

Effect of Herbicide Glyphosate on Drosophila melanogaster Fertility and Lifespan.

Galin RR ，Akhtyamova IF ，Pastukhova EI 《-》

Resistance to oxidative stress induced by paraquat correlates well with both decreased and increased lifespan in Drosophila melanogaster.

Vermeulen CJ ，Van De Zande L ，Bijlsma R 《BIOGERONTOLOGY》