Lutein extends the lifespan of Drosophila melanogaster.

Lutein is one of the major carotenoids in most fruits and vegetables. The effect of lutein on the lifespan of Drosophila melanogaster was investigated. Results revealed that 0.1mg lutein/ml diet could prolong their mean lifespan from 49.0 to 54.6 days. This was consistent with a significant reduction in malonyldialdehyde (MDA) level and increase in antioxidant enzyme activities of the flies fed with lutein-treated diet compared with those fed with basal diet. Paraquat (PQ) and H2O2 treatment tests demonstrated that lutein could prolong the survival time of the flies. Real-time polymerase chain reaction (RT-PCR) analysis indicated the gene expression of superoxide dismutase (SOD; SOD1 and SOD2), and catalase (CAT) in the lutein-treated group was up-regulated relative to that of the control group. It was concluded that the lifespan-prolonging activity of lutein was partially by up-regulation of endogenous antioxidant enzymes.

Zhang Z ，Han S ，Wang H ，Wang T ... -  《-》

Black rice extract extends the lifespan of fruit flies.

Zuo Y ，Peng C ，Liang Y ，Ma KY ，Yu H ，Edwin Chan HY ，Chen ZY ... -  《-》

Sesamin extends the mean lifespan of fruit flies.

Zuo Y ，Peng C ，Liang Y ，Ma KY ，Chan HY ，Huang Y ，Chen ZY ... -  《-》

Apple polyphenols extend the mean lifespan of Drosophila melanogaster.

Peng C ，Chan HY ，Huang Y ，Yu H ，Chen ZY ... -  《-》

Blueberry extract prolongs lifespan of Drosophila melanogaster.

Blueberry possesses greater antioxidant capacity than most other fruits and vegetables. The present study investigated the lifespan-prolonging activity of blueberry extracts in fruit flies and explored its underlying mechanism. Results revealed that blueberry extracts at 5mg/ml in diet could significantly extend the mean lifespan of fruit flies by 10%, accompanied by up-regulating gene expression of superoxide dismutase (SOD), catalase (CAT) and Rpn11 and down-regulating Methuselah (MTH) gene. Intensive H(2)O(2) and Paraquat challenge tests showed that lifespan was only extended in Oregon-R wild type flies but not in SOD(n108) or Cat(n1) mutant strains. Chronic Paraquat exposure shortened the maximum survival time from 73 to 35days and decreased the climbing ability by 60% while blueberry extracts at 5mg/ml in diet could significantly increase the survival rate and partially restore the climbing ability with up-regulating SOD, CAT, and Rpn11. Furthermore, gustatory assay demonstrated that those changes were not due to the variation of food intake between the control and the experimental diet containing 5mg/ml blueberry extracts. It was therefore concluded that the lifespan-prolonging activity of blueberry extracts was at least partially associated with its interactions with MTH, Rpn11, and endogenous antioxidant enzymes SOD and CAT.

Peng C ，Zuo Y ，Kwan KM ，Liang Y ，Ma KY ，Chan HY ，Huang Y ，Yu H ，Chen ZY ... -  《-》