Regional gray and white matter volume abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study.

Previous studies have demonstrated both functional and structural abnormalities in the frontal-striatal-thalamic circuits in obsessive-compulsive disorder (OCD). The purpose of this study was to assess volume abnormalities not only of gray matter (GM), but also of white matter (WM) in patients with OCD using voxel-based morphometry (VBM). Subjects consisted of 23 patients with OCD and 26 normal control subjects. All patients were drug-free for at least 2 weeks before the study. Three-dimensional T1-weighed MR images were obtained in all subjects. Optimized voxel-based morphometry was performed to detect structural difference between the two groups. The patients with OCD demonstrated a significant reduction of GM volume in the bilateral medial prefrontal cortex, right premotor area, right orbitofrontal cortex (OFC), right dorsolateral prefrontal cortex, and bilateral temporal and occipital regions. The OCD patients also showed a significant WM volume increase in the right anterior limb of the internal capsule, right orbitofrontal region, and a significant WM volume reduction in the left anterior cingulate gyrus. Our findings are consistent with previous studies implicating dysfunction of the frontal cortex including the OFC. The results suggested that WM volume abnormalities in the orbitofrontal region, anterior limb of the internal capsule, and anterior cingulate gyrus would imply abnormalities in the pathways of frontal-striatal circuits.

Togao O ，Yoshiura T ，Nakao T ，Nabeyama M ，Sanematsu H ，Nakagawa A ，Noguchi T ，Hiwatashi A ，Yamashita K ，Nagao E ，Kanba S ，Honda H ... -  《PSYCHIATRY RESEARCH》

The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems.

van den Heuvel OA ，Remijnse PL ，Mataix-Cols D ，Vrenken H ，Groenewegen HJ ，Uylings HB ，van Balkom AJ ，Veltman DJ ... -  《-》

Regional gray matter abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study.

Valente AA Jr ，Miguel EC ，Castro CC ，Amaro E Jr ，Duran FL ，Buchpiguel CA ，Chitnis X ，McGuire PK ，Busatto GF ... -  《BIOLOGICAL PSYCHIATRY》

Medial frontal and dorsal cortical morphometric abnormalities are related to obsessive-compulsive disorder.

Koprivová J ，Horácek J ，Tintera J ，Prasko J ，Raszka M ，Ibrahim I ，Höschl C ... -  《-》

White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study.

Szeszko PR ，Ardekani BA ，Ashtari M ，Malhotra AK ，Robinson DG ，Bilder RM ，Lim KO ... -  《archives of general psychiatry》