自引率: 9.4%
被引量: 21802
通过率: 暂无数据
审稿周期: 3.33
版面费用: 暂无数据
国人发稿量: 75
投稿须知/期刊简介:
The journal provides very rapid publication of short but complete research reports in the field of psychiatry. The scope of the journal encompasses: (1) Biochemical, physiological, genetic, psychological, and social determinants of human behavior; (2) assessment of human behavior and subjective state; (3) evaluation of somatic and non-somatic psychiatric treatments. In addition, reports of clinically related basic studies in the fields of neuropharmacology, neurochemistry, neuroendocrinology, electrophysiology, psychology, genetics, and brain imaging are published. Significant methodological advances such as instrumentation, clinical scales, and assays directly applicable to psychiatric research are also appropriate. Brief reviews, theoretical contributions, and letters to the editor will be considered.
期刊描述简介:
The journal provides very rapid publication of short but complete research reports in the field of psychiatry. The scope of the journal encompasses: (1) Biochemical, physiological, genetic, psychological, and social determinants of human behavior; (2) assessment of human behavior and subjective state; (3) evaluation of somatic and non-somatic psychiatric treatments. In addition, reports of clinically related basic studies in the fields of neuropharmacology, neurochemistry, neuroendocrinology, electrophysiology, psychology, genetics, and brain imaging are published. Significant methodological advances such as instrumentation, clinical scales, and assays directly applicable to psychiatric research are also appropriate. Brief reviews, theoretical contributions, and letters to the editor will be considered.
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Dermatoglyphic indices and minor physical anomalies in patients with schizophrenia and related disorders, their first-degree biological relatives, and non psychiatric controls.
Abnormalities in dermatoglyphic indices and minor physical anomalies (MPAs) are two permanent markers of fetal development that have been studied in schizophrenia. This study sought to: (1) compare select dermatoglyphic indices across patients, first-degree relatives, and non psychiatric controls; (2) assess for associations between dermatoglyphic indices and symptoms in patients and schizotypal features in relatives and controls; and (3) examine correlations between dermatoglyphics and MPAs. The two types of markers were assessed in 62 patients with schizophrenia and related disorders, 36 of their unaffected first-degree relatives, and 47 non psychiatric controls. Symptoms were measured in patients and schizotypy was assessed in relatives and controls. Analyses took into account potential demographic confounders and non independence between patients and relatives. No significant differences in dermatoglyphic indices (total finger ridge count; ridge count asymmetry; numbers of arches, loops, and whorls) were found across the three groups. Patients' and their own relatives' dermatoglyphic indices were moderately to strongly correlated (rho=0.33-0.66). Dermatoglyphic indices were unrelated to patients' cross-sectional symptom severity and were generally unrelated to relatives' and controls' levels of schizotypy. Several correlations among dermatoglyphic indices and MPAs were found in this exploratory analysis, particularly among relatives and controls. Implications for future research are discussed.
被引量：4 发表：1970
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Risk for obstetric complications and schizophrenia.
The goal of this study was to determine whether cases with schizophrenia or related disorders show a history of obstetric complications significantly more often than control subjects and, if so, whether the enhanced risk of a negative pregnancy outcome also extends to the non-schizophrenic offspring of cases. Data based on the obstetric birth case-notes of patients with diagnosed schizophrenia or related disorders were compared to those of normal 'healthy' control subjects; each case/control pair was individually matched by gender, time and parity of birth, maternal age and marital status. Forty-four case/control pairs born in Padova (Italy) between 1964 and 1978 were assessed for prenatal and perinatal complications, including abnormal gestational age or birthweight. No significant differences were observed between cases and control subjects in the general characteristics of birth; gestational age and birthweight in particular were strictly comparable between cases and control subjects. The schizophrenia spectrum patients (75%) were more likely than control subjects (59%) to have experienced at least one definite obstetric complication: odds ratio=2.07 (95% CI: 0.83-5. 15). Cases also suffered more complications per birth than control subjects (average 2:1). In particular, obstetric complications involving a clear damaging potential were seen significantly more often among cases than control subjects: 34% vs. 9%, Fisher's exact test, P=0.008 (odds ratio=5.17, 95% CI: 1.55-17.21). Moreover, severe obstetric complications were noted more often among males (n=13, 41%) than females (n=2, 15%). When any previous pregnancies of the mothers of patients were compared with those of the mothers of control subjects, mothers of cases were seen to have suffered unfavorable pregnancy outcomes significantly more often. In particular mothers of cases were seen to have had more miscarriages (OR=4.66), and pre-term births (OR=2.58) than control subects' mothers. Severe, brain-damaging obstetric complications would seem to be a possible antecedent to a diagnosis of schizophrenia or a related disorder in adulthood. Indeed, some early onset cases may be accounted for by prenatal brain lesions. This enhanced risk of negative pregnancy outcome may be under genetic control, contributing to the persistence of schizophrenia in the general population. The 'healthy' status of control subjects was ascertained indirectly, not by individual assessment of the subjects. The sample size limits the statistical power of calculations.
被引量：10 发表：2000
