自引率: 3.1%
被引量: 1438
通过率: 暂无数据
审稿周期: 2
版面费用: 暂无数据
国人发稿量: 18
投稿须知/期刊简介:
Published by Sage Publications. ISSN (printed): 1753-4259. ISSN (electronic): 1753-4267.<br> Innate Immunity is a highly ranked, peer reviewed scholarly journal, first published as Journal of Endotoxin Research
期刊描述简介:
Innate Immunity is a highly ranked, peer-reviewed open access journal and is the official journal of the International Endotoxin & Innate Immunity Society (IEIIS). The journal welcomes manuscripts from researchers actively working on all aspects of innate immunity including biologically active bacterial, viral, fungal, parasitic, and plant components, as well as relevant cells, their receptors, signaling pathways, and induced mediators. The aim of the journal is to provide a single, interdisciplinary forum for the dissemination of new information on innate immunity in humans, animals, and plants to researchers. The journal creates a vehicle for the publication of articles encompassing all areas of research: basic, applied, and clinical. The subject areas of interest include, but are not limited to: research in biochemistry, biophysics, cell biology, chemistry, clinical medicine, immunology, infectious diseases, microbiology, molecular biology, and pharmacology.
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Retraction notice.
被引量：- 发表：1970
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CRISPR activation as a platform to identify interferon stimulated genes with anti-viral function.
被引量：- 发表：1970
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Acacetin protects against sepsis-induced acute lung injury by facilitating M2 macrophage polarization via TRAF6/NF-κB/COX2 axis.
被引量：2 发表：1970
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Obesity Alters cytokine signaling and gut microbiome in septic mice.
被引量：1 发表：1970
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Gene expression analysis in human polymorphonuclear leukocytes stimulated by LPSs from nosocomial opportunistic pathogens.
Innate immunity coordinates LPS detection via TLR4 on polymorphonuclear leukocytes (PMNs) to elicit responses to many Gram-negative bacteria. In this study, we describe the effects of five subtypes of LPS [isolated from Escherichia coli B4, Pseudomonas aeruginosa PAO1, multidrug-resistant P. aeruginosa (MDRP), Acinetobacter baumannii and multidrug-resistant A. baumannii (MDRA)] on gene expression in PMNs. LPS isolated from B4, PAO1, and A. baumannii did not significantly alter TLR2 expression. However, LPS from MDRP and MDRA caused a 0.6-fold decrease and 2.7-fold increase, respectively, in TLR2 expression. Similarly, TLR4 expression was not significantly altered by LPS isolated from B4, PAO1 and A. baumannii but was down-regulated by LPS isolated from MDRP and MDRA by 0.1- and 0.6-fold, respectively. All LPS subtypes, excluding PAO1, down-regulated CD14 expression in PMNs. However, all five LPS subtypes up-regulated TNFA, IL1B, IL6, IL10 and TREM1 expression in a concentration-dependent manner, with the most substantial responses observed following exposure to LPS from MDRP and MDRA. These different effects on the gene expression in PMNs may depend on variation in LPS structural modifications related to acquired drug resistance, such as acylation and/or glycosylation.
被引量：10 发表：1970
