自引率: 5.2%
被引量: 137983
通过率: 暂无数据
审稿周期: 3.15
版面费用: 暂无数据
国人发稿量: 2014
投稿须知/期刊简介:
The Journal of Hazardous Materials publishes full length research papers, reviews, project reports, case studies and short communications which improve our understanding of the hazards and risks certain materials pose to people and the environment or deal with ways of controlling the hazards and associated risks. To limit the scope the following areas are excluded: work place health & safety, drugs, and nuclear related topics. The Journal is published in two parts: Part A: Risk Assessment and Management Characterization of the harmful effects of hazardous materials Impact assessment methods and models - acute and chronic effects of hazardous chemical releases Approaches to risk assessment and management, including legislation Incident case histories and lessons for risk management Part B Environmental Technologies Pollution control processes Inherently safer and cleaner technologies Treatment and disposal of solid, liquid and gaseous hazardous wastes Remediation of contaminated soil and groundwater.
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Polystyrene nanoplastics sequester the toxicity mitigating potential of probiotics by altering gut microbiota in grass carp (Ctenopharyngodon idella).
This study evaluated the role of probiotics in enhancing intestinal immunity and mitigating polystyrene nanoplastics (PS-NPs)-induced toxicity in grass carp (Ctenopharyngodon idella). Grass carp were fed probiotics (Bacillus subtilis, Bacillus velezensis, Lactobacillus reuteri, and Lactococcus lactis) for two weeks before being exposed to PS-NPs for five days. Probiotic pretreatment alleviated PS-NPs-induced intestinal damage, with Bacillus velezensis and Lactococcus lactis groups showing milder vacuolation and villus breakage than other groups. Probiotic-treated fish exhibited transient increases in antioxidant enzyme activities (CAT, SOD, MPO) and immune gene expression (IL-6, IL-8, IL-10, IL-1β, TNF-α, and IFN-γ2) shortly after exposure, followed by significant downregulation over time. Higher abundance of the gut dominant phylum Proteobacteria was observed in four probiotic groups exposed to PS-NPs than that in the blank control group. The Clostridium phylum showed a significant decrease in the abundance both in the LRS-PS100 and LLS-PS100 groups, while the abundance of the Thick-walled phylum increased. The Spearman correlation matrix revealed that specific gut microbiota, such as Serratia, Neisseria, and Lactococcus, were significantly associated with enzymatic activities and immune system related genes' expressions. Probiotic pretreatment enhanced the intestinal immune response of grass carp. However, this enhanced immune response was insufficient to counteract the toxic effects of PS-NPs exposure, particularly in terms of oxidative stress levels and gut microbial diversity. This study offers new insights into the potential of probiotics to combat NPs pollution in aquaculture. It emphasizes the need for further research to explore various probiotic combinations. Future studies should also investigate optimal dosages and durations to effectively mitigate the biological toxicity of NPs pollution.
被引量：- 发表：1970
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Ultra-sensitive detection of norovirus using a three-in-one CRISPR platform based on a DNA hydrogel and composite functional nanomaterials.
The ultrasensitive sensor with three optical response mechanisms was proposed for the determination of trace amounts of norovirus using a 3-in-1 GCSNAs (a gap-containing spherical nucleic acid nanoparticles) probe. A simple and highly sensitive three-mode biosensor with Raman, colorimetric, and fluorescence functions was proposed and implemented using the GCSNAs probe and a DNA hydrogel for norovirus detection. When the virus exists, the trans-cleavage activity of CRISPR-Cas12a was activated by double-stranded dsDNA (dsDNA) generated by reverse transcription and recombinase polymerase isothermal amplification (RT-RPA) to degrade the DNA hydrogel/GCSNA composition and release the three-in-one (3-in-1) probe-GCSNA, realising the triple ultrasensitive detection of norovirus. The colorimetric sensing mode allows for semi-quantitative on-site detection, which is visible to the naked eye and the quantitative detection can be achieved by conducting grayscale analysis using the "Colour Grab" function of a smartphone. This new triple sensor achieved the successful quantification of norovirus at concentrations as low as the femtomolar scale with an excellent selectivity and accuracy. Considering the colorimetric properties of rolling circle amplification (RCA)-based DNA hydrogels and GCSNAs, the proposed method has a broad application prospect in virus on-site detection in food. It should be applicable for virus detection in a wide range of fields such, as environmental analysis, medical diagnosis, and food safety. It is anticipated that this mechanism will open new avenues for the development of multimodal analyses and multifunctional sensing platforms for various applications. We anticipate that this sensing mechanism will open up a new way for the development of food safety detection.
被引量：- 发表：1970
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Unveiling the environmental impact of tire wear particles and the associated contaminants: A comprehensive review of environmental and health risk.
This review offers a novel perspective on the environmental fate and ecotoxicological effects of tire wear particles (TWPs), ubiquitous environmental contaminants ranging in size from micrometers to millimeters (averaging 10-100 micrometers). These particles pose a growing threat due to their complex chemical composition and potential toxicity. Human exposure primarily occurs through inhalation, ingesting contaminated food and water, and dermal contact. Our review delves into the dynamic interplay between TWP composition, transformation products (TPs), and ecological impacts, highlighting the importance of considering both individual chemical effects and potential synergistic interactions. Notably, our investigation reveals that degradation products of certain chemicals, such as diphenylguanidine (DPG) and diphenylamine (DPA), can be more toxic than the parent compounds, underscoring the need to fully understand these contaminants' environmental profile. Furthermore, we explore the potential human health implications of TWPs, emphasizing the need for further research on potential respiratory, cardiovascular, and endocrine disturbances. Addressing the challenges in characterizing TWPs, assessing their environmental fate, and understanding their potential health risks requires a multidisciplinary approach. Future research should prioritize standardized TWP characterization and leachate analysis methods, conduct field studies to enhance ecological realism, and utilize advanced analytical techniques to decipher complex mixture interactions and identify key toxicants. By addressing these challenges, we can better mitigate the environmental and health risks associated with TWPs and ensure a more sustainable future.
被引量：- 发表：1970
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Trophic transfer induced gut inflammation, dysbiosis, and inflammatory pathways in zebrafish via Artemia franciscana: A differential analysis of nanoplastic toxicity.
Rising glbal population and plastic consumption have caused a dramatic increase in plastic waste, leading to micro- and nanoplastic ingestion by aquatic organisms and subsequent bioaccumulation in their tissues. This transfer to higher trophic levels raises nanoplastic concentrations and bioavailability, potentially harming organisms' health and development. This poses a risk to human health via seafood. To address these issues, this study assesses the toxicological impacts of nanoplastics (NPs) on brine shrimp (Artemia franciscana) and their trophic transfer to zebrafish. The research unveiled concentration-dependent bioaccumulation of NPs in zebrafish and Artemia franciscana (A. franciscana). Polystyrene nanoplastics (PS-NPs) exhibited higher accumulation in A. franciscana whereas PP-NPs showed greater accumulation in zebrafish gut. Histopathological analysis under PS-NPs exposure revealed significant tissue alterations, indicative of inflammatory responses and impaired mucosal barrier integrity. Gene expression analyses confirmed these findings, showing activation of the P38-MAPK pathway by PS-NPs, which correlated with increased inflammatory cytokines. Additionally, PE-NPs activated the JNK-MAPK pathway, while PP-NPs exposure triggered the NOD-like receptor signaling pathway. Moreover, the composition of gut microbiota shifted to a dysbiotic state, characterized by an increase in pathogenic bacteria in the PS-NPs and PP-NPs groups, elevating the risk of developing Inflammatory Bowel Disease (IBD). PS-NPs were regarded as the most toxic due to their lower stability and higher aggregation tendencies, followed by PP-NPs and PE-NPs. Taken together, the overall study highlighted the complex interactions between NPs, gut microbiota, and host health, emphasizing the importance of thoroughly assessing the ecological and physiological impacts of nanoplastic pollution.
被引量：- 发表：1970
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Low-dose deoxynivalenol exposure triggers hepatic excessive ferritinophagy and mitophagy mitigated by hesperidin modulated O-GlcNAcylation.
The level and breadth of deoxynivalenol (DON) contamination in foods made with cereals have increased due to global warming. Consumption of DON-contaminated food and feed poses significant risks to human health and animal production. However, the mechanism by which prolonged exposure to low-dose DON leads to liver damage in animals and effective treatments remain unclear. Our investigation focused on the impact of varying DON exposure times on AML12 cells as well as the long-term liver damage caused by low-dose DON exposure in mice. In addition, this article investigated the unique role of hesperidin in mitigating hepatic ferroptosis induced by low-dose DON exposure. Our results imply that DON's suppression of O-GlcNAcylation exacerbated mitophagy by encouraging ferritinophagy and causing labile iron to aggregate within mitochondria. Furthermore, DON could increase NCOA4-mediated ferritinophagy by De-O-GlcNAcylation FTH to trigger ferroptosis-associated liver injury in mice. Notably, hesperidin alleviated the susceptibility to ferroptosis by increasing O-GlcNAcylation levels and effectively attenuated the liver injury induced by low-dose DON exposure. This finding provides a new strategy for dealing with liver injury caused by low-dose DON exposure.
被引量：- 发表：1970
