摘要：

This review offers a novel perspective on the environmental fate and ecotoxicological effects of tire wear particles (TWPs), ubiquitous environmental contaminants ranging in size from micrometers to millimeters (averaging 10-100 micrometers). These particles pose a growing threat due to their complex chemical composition and potential toxicity. Human exposure primarily occurs through inhalation, ingesting contaminated food and water, and dermal contact. Our review delves into the dynamic interplay between TWP composition, transformation products (TPs), and ecological impacts, highlighting the importance of considering both individual chemical effects and potential synergistic interactions. Notably, our investigation reveals that degradation products of certain chemicals, such as diphenylguanidine (DPG) and diphenylamine (DPA), can be more toxic than the parent compounds, underscoring the need to fully understand these contaminants' environmental profile. Furthermore, we explore the potential human health implications of TWPs, emphasizing the need for further research on potential respiratory, cardiovascular, and endocrine disturbances. Addressing the challenges in characterizing TWPs, assessing their environmental fate, and understanding their potential health risks requires a multidisciplinary approach. Future research should prioritize standardized TWP characterization and leachate analysis methods, conduct field studies to enhance ecological realism, and utilize advanced analytical techniques to decipher complex mixture interactions and identify key toxicants. By addressing these challenges, we can better mitigate the environmental and health risks associated with TWPs and ensure a more sustainable future.

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