Bcl-2 family expression in salivary glands from patients with primary Sjögren's syndrome: involvement of Bax in salivary gland destruction.

To investigate the molecular mechanism of glandular parenchyma destruction in Sjögren's syndrome (SS), Bcl-2, Bax, Bcl-X, and Bak expression were studied. SS (n = 18) and control salivary glands (n = 6) were examined by immunohistochemistry. Apoptosis was assessed by in situ DNA nick end labeling. Infiltrating mononuclear cells in the SS salivary gland showed elevated Bcl-2. These mononuclear cells expressed increased Bax but did not undergo apoptosis. Both SS and control salivary gland ductal epithelial cells expressed Bcl-2, Bax, and Bcl-X. SS, but not normal, salivary gland acinar cells expressed Bax and underwent apoptosis. These results suggest that elevated Bax expression in SS salivary gland acinar cells may play an important role in the apoptotic pathway. In contrast, Bcl-2 expression in SS infiltrating mononuclear cells and ductal cells may contribute to their survival.

Kong L ，Ogawa N ，McGuff HS ，Nakabayashi T ，Sakata KM ，Masago R ，Vela-Roch N ，Talal N ，Dang H ... -  《-》

CD40, CD154, Bax and Bcl-2 expression in Sjögren's syndrome salivary glands: a putative anti-apoptotic role during its effector phases.

Ohlsson M ，Szodoray P ，Loro LL ，Johannessen AC ，Jonsson R ... -  《SCANDINAVIAN JOURNAL OF IMMUNOLOGY》

Modes of epithelial cell death and repair in Sjögren's syndrome (SS).

Polihronis M ，Tapinos NI ，Theocharis SE ，Economou A ，Kittas C ，Moutsopoulos HM ... -  《-》

Expression of CD40/CD40 ligand and Bcl-2 family proteins in labial salivary glands of patients with Sjögren's syndrome.

Nakamura H ，Kawakami A ，Tominaga M ，Migita K ，Kawabe Y ，Nakamura T ，Eguchi K ... -  《LABORATORY INVESTIGATION》

Fas and Fas ligand expression in the salivary glands of patients with primary Sjögren's syndrome.

Kong L ，Ogawa N ，Nakabayashi T ，Liu GT ，D'Souza E ，McGuff HS ，Guerrero D ，Talal N ，Dang H ... -  《-》