Neurodevelopmental schizophrenia: the rediscovery of dementia praecox.

Many people with severe schizophrenia have increased cerebral ventricular size and diffuse reduction in cortical volume; recent attention has focused on subtle malformations of the cytoarchitecture in the hippocampus and parahippocampal cortex. Sufferers also show an excess of dermatoglyphic and minor physical abnormalities, and a significant proportion had psychomotor deficits, cognitive or behavioural problems as children. Such findings suggest that the form of schizophrenia most akin to Kraepelin's original description of dementia praecox results from neurodevelopmental impairment. This may have its origin in genetic defects in the control of early brain growth, or in early environmental hazards such as prenatal exposure to maternal influenza or perinatal complications. How foetal or neonatal lesions produce hallucinations and delusions two or three decades later remains a mystery, but maturational changes in the brain may be important.

Murray RM 《-》

[Neurodevelopmental models of schizophrenia].

Verdoux H 《ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE》

[Frontal dementia or dementia praecox? A case report of a psychotic disorder with a severe decline].

Vanderzeypen F ，Bier JC ，Genevrois C ，Mendlewicz J ，Lotstra F ... -  《ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE》

Neurodevelopmental factors associated with schizotypal symptoms among adolescents at risk for schizophrenia.

Hans SL ，Auerbach JG ，Nuechterlein KH ，Asarnow RF ，Asarnow J ，Styr B ，Marcus J ... -  《-》

The relationship of minor physical anomalies and other putative indices of developmental disturbance in schizophrenia to abnormalities of cerebral structure on magnetic resonance imaging.

O'Callaghan E ，Buckley P ，Madigan C ，Redmond O ，Stack JP ，Kinsella A ，Larkin C ，Ennis JT ，Waddington JL ... -  《BIOLOGICAL PSYCHIATRY》