Isobavachalcone-loaded electrospun polycaprolactone/gelatin nanofibers for antibacterial and antioxidant applications.

Antibacterial nanofibers have been widely used in the fields of biomedicine and food packaging fields. To overcome existing antibiotic resistance, this study utilized isobavachalcone (IBC), a natural compound with antibacterial and antioxidant properties, combined with polycaprolactone (PCL) and gelatin (GEL) to develop an electrospun nanofibrous antibacterial membrane. Scanning electron microscopy (SEM) analysis revealed a uniform and smooth surface structure of the nanofiber. Fourier transform infrared spectroscopy and x-ray diffraction confirmed the interactions among the components of the nanofibrous membrane PCL/GEL/IBC (PGI). Thermogravimetric analysis and contact angle measurements demonstrated the thermal stability and hydrophilic nature. Additionally, the mechanical properties of PGI membrane were that the elongation at break increased to 19.9% and the tensile strength to 2.9 MPa.In vitrorelease studies indicated at least 48% release rate of IBC from the PGI nanofibrous membrane in 12 h, and release period up to 14 d. Antioxidant results revealed PGI membranes had fine abilities for scavenging free radical. The elimination of over 99% ofStaphylococcus aureusand elimination of 54%Candida albicansdemonstrated the antibacterial capacities of the PGI membrane, indicating its potential as antibacterial and antioxidant materials. Subsequent faster wound healing, lower oxidative damage for 4-HNE and 8-OHdG, further demonstrated that PGI can reduce oxidative damage at the wound and promote wound healing. These findings also suggest the potential of PGI in the field of tissue engineering.

Guo P ，Zhang W ，Zhao P ，Lv X ，Qu A ，Liang W ，Hou H ，Li Y ，Wu Z ... -  《-》

Engineered Robust Hydrophobic/Hydrophilic Nanofibrous Scaffolds with Drug-Eluting, Antioxidant, and Antimicrobial Capacity.

Soleimani F ，Pellerin C ，Omidfar K ，Bagheri R ... -  《-》

Effect of Tetrapropylammonium Chloride Quaternary Ammonium Salt on Characterization, Cytotoxicity, and Antibacterial Properties of PLA/PEG Electrospun Mat.

In this study, poly(lactic acid) (PLA)-tetrapropylammonium chloride (TCL)-poly(ethylene glycol) (PEG) nonwoven networks were produced using PLA, PEG with different concentrations (3, 5, 7, and 9 wt%), and TCL. PEG is included as a plasticizer in PLA polymer, which has high biocompatibility but a brittle structure. The importance of this study is to investigate the effect of TCL salt on the characterization of PLA-PEG nanofibers. For this research, the cytotoxicity test system responsible for the fibroblast cell line (L929) was evaluated with the liquid absorption capacity (LAC) and drying time tests for its use in wound dressings. The addition of TCL salt reduced bead formation in PLA-PEG nanofibers and increased the homogeneity of fiber dispersion. The smoothest and most homogeneous nonwoven networks were obtained as PLA-5TCL-PEG. It was also reported that this nonwoven network exhibited liquid absorption behavior with a maximum increase of 150% compared to the PLA-PEG nonwoven network and had the highest Young's modulus value of 12.97 MPa. In addition to these tests, evaluations were made with Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), drying time test, differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and mechanical tests. In addition, high cell viability was observed in L292 mouse fibroblast cells at the end of the 24th hour, again with the effect of TCL salt. In addition, antibacterial activity was tested against gram-negative E. coli and gram-positive S. aureus bacteria, and it was observed that there was no antibacterial activity. Since PLA-TCL-PEG nonwoven webs have a maximum cell viability of 133.27%, they are recommended as a potential dermal wound dressing.

Şener SÖ ，Samatya Yilmaz S ，Doganci MD ，Doganci E ... -  《-》

[Effects of methacrylic anhydride gelatin hydrogel loaded with silver and recombinant human basic fibroblast growth factor on deep partial-thickness burn wounds in rabbits].

Chen XJ ，Wu X ，Lin HH ，Liu ZX ，Liu S ... -  《-》

Antibacterial, Anti-Inflammatory, and Antioxidant Cotton-Based Wound Dressing Coated with Chitosan/Cyclodextrin-Quercetin Inclusion Complex Nanofibers.

Alishahi M ，Xiao R ，Kreismanis M ，Chowdhury R ，Aboelkheir M ，Lopez S ，Altier C ，Bonassar LJ ，Shen H ，Uyar T ... -  《-》