Contrıbutıon of Kaıser score in non-mass enhanced breast lesions.

Our study aimed to investigate the effectiveness of Kaiser Score (KS) in diagnosing Non-mass enhanced (NME) lesions and its impact on the inter-reader agreement between experienced and inexperienced readers. A retrospective analysis was conducted on 189 NME lesions from 182 MRIs. Two readers (an experienced radiologist and a radiology resident) independently evaluated lesions using the KS, blinded to clinical and pathological data. The KS was modified (MKS) by adding 2 points for microcalcifications on mammography and subtracting 4 points for ADC values > 1.4 x 10^-3 mm2/s. Interobserver agreement was assessed with the Intraclass Correlation Coefficient (ICC), and diagnostic performance was evaluated via ROC analysis, with sensitivity and specificity calculated at > 4 and > 5 cut-offs. Interobserver agreement improved with MKS (ICC: 0.763) compared to KS (ICC: 0.667). For the experienced reader, both KS and MKS achieved high sensitivity (>94 %) at a cut-off of > 4. At > 5, specificity improved from 40.5 % to 58.7 % for KS and 39.1 % to 55.8 % for MKS without significantly affecting sensitivity. For the inexperienced reader, MKS improved sensitivity (96.8 %) and specificity (39 %) at > 4. At > 5, specificity increased to 55.8 %, with a non-significant decrease in sensitivity (86.2 %). The Kaiser Score is a quick and systematic tool that enhances diagnostic accuracy and reduces biopsy rates, particularly benefiting inexperienced readers. While higher thresholds improve specificity for experienced readers, they may reduce sensitivity for inexperienced readers, potentially missing malignancies. As a complement to BI-RADS, the Kaiser Score helps standardize evaluations and bridge experience gaps in MRI interpretation.

Karabulut UE ，Celik Yabul F ，Polat YB ，Donmez Z ，Toprak H ，Alkan A ，Yildiz S ... -  《-》

Breast lesions on MRI in mass and non-mass enhancement: Kaiser score and modified Kaiser score + for readers of variable experience.

To compare the diagnostic performance of three readers using BI-RADS and Kaiser score (KS) based on mass and non-mass enhancement (NME) lesions. A total of 630 lesions, 393 malignant and 237 benign, 458 mass and 172 NME, were analyzed. Three radiologists with 3 years, 6 years, and 13 years of experience made diagnoses. 596 cases had diffusion-weighted imaging, and the apparent diffusion coefficient (ADC) was measured. For lesions with ADC > 1.4 × 10-3 mm2/s, the KS was reduced by 4 as the modified KS +, and the benefit was assessed. When using BI-RADS, AUC was 0.878, 0.915, and 0.941 for mass, and 0.771, 0.838, 0.902 for NME for Reader-1, 2, and 3, respectively, better for mass than for NME. The diagnostic accuracy of KS was improved compared to BI-RADS for less experienced readers. For Reader-1, AUC was increased from 0.878 to 0.916 for mass (p = 0.005) and from 0.771 to 0.822 for NME (p = 0.124). Based on the cut-off value of BI-RADS ≥ 4B and KS ≥ 5 as malignant, the sensitivity of KS by Readers-1 and -2 was significantly higher for both Mass and NME. When ADC was considered to change to modified KS +, the AUC and the accuracy for all three readers were improved, showing higher specificity with slightly degraded sensitivity. The benefit of KS compared to BI-RADS was most noticeable for the less experienced readers in improving sensitivity. Compared to KS, KS + can improve specificity for all three readers. For NME, the KS and KS + criteria need to be further improved. KS provides an intuitive method for diagnosing lesions on breast MRI. BI-RADS and KS face greater difficulties in evaluating NME compared to mass lesions. Adding ADC to the KS can improve specificity with slightly degraded sensitivity. KS provides an intuitive method for interpreting breast lesions on MRI, most helpful for novice readers. KS, compared to BI-RADS, improved sensitivity in both mass and NME groups for less experienced readers. NME lesions were considered during the development of the KS flowchart, but may need to be better defined.

Zhou J ，Liu H ，Miao H ，Ye S ，He Y ，Zhao Y ，Chen Z ，Zhang Y ，Liu YL ，Pan Z ，Su MY ，Wang M ... -  《-》

Diagnostic performance of the Kaiser score for contrast-enhanced mammography and magnetic resonance imaging in breast masses: A Comparative Study.

The Kaiser score (KS) is a simple and intuitive machine-learning derived decision rule for characterizing breast lesions in a clinical setting and screening for breast cancer. The present study aims to investigate the applicability of the KS for contrast-enhanced mammography (CEM) in breast masses, and to compare its diagnostic accuracy with magnetic resonance imaging (MRI). CEM may provide an alternative option for patients with breast masses, especially for those with MRI contraindications. Two hundred and seventy-five patients with breast enhanced masses were included in the study from May 2019 to September 2022. Patients were further divided into benign and malignant groups based on pathological diagnosis. The CEM and MRI imaging characteristics of these two groups were analyzed statistically. The paired chi-square and Cohen's kappa coefficient (κ) analysis were used to compare imaging characteristics between CEM and MRI. The Breast Imaging Reporting and Data System (BI-RADS) and KS for CEM and MRI were evaluated based on imaging characteristics. The diagnostic performance of BI-RADS and KS for CEM and MRI was assessed and compared using receiver operating characteristic (ROC) analysis and DeLong's test. The imaging characteristics of root sign, time-signal intensity curve (TIC/mTIC), margin, internal enhancement pattern (IEP), edema, apparent diffusion coefficient (ADC) values, and suspicious malignant microcalcifications showed significant differences between benign and malignant lesions (all p ≤ 0.011). The detection rate of root sign and margin showed substantial agreement between CEM and MRI (κ = 0.656, κ = 0.640), but IEP, TIC/mTIC, and edema showed poor agreement (κ = 0.380, κ = 0.320, κ = 0.324). For all lesion analyses, the area under the curves (AUCs) of the KS (0.897 ∼ 0.932) were higher than that of BI-RADS (0.691) in CEM (all p < 0.001). The AUC of KS (calcification)-CEM (0.932) was higher than those of both KS-CEM and KS (edema)-CEM (0.897 and 0.899) (all p < 0.001). For subgroup analyses, the AUCs of the KS (0.875 ∼ 0.876) were higher than that of BI-RADS (0.740) in MRI (all p < 0.001). The AUCs of KS-MRI (0.876) and KS (ADC)-MRI (0.875) were similar to those of KS-CEM (0.878) and KS (edema)-CEM (0.870) (all p > 0.100). The AUC of KS (calcification)-CEM (0.934) was slightly higher than those of both KS-MRI (0.876) and KS (ADC)-MRI (0.875), but no significant difference was observed (p = 0.051; p = 0.071). The KS for CEM provided high diagnostic accuracy in distinguishing breast masses, comparable to that of MRI. The application of KS (calcification)-CEM combined with suspicious malignant microcalcifications can improve diagnostic efficiency with an AUC of 0.932 ∼ 0.934. However, edema did not significantly improve performance when using the KS for CEM.

Hua B ，Yang G ，Wang Y ，Chen J ，Rong X ，Yuan T ，Quan G ... -  《-》

Assessment of the contribution of the ADC value to the Kaiser score in the differential diagnosis of breast lesions with non-mass enhancement morphology on MRI.

To investigate the effectiveness of diffusion-weighted imaging (DWI) as a supplementary tool to the Kaiser score (KS) in diagnosing breast cancer in non-mass enhancement (NME) lesions using breast magnetic resonance imaging (MRI). This single-center, retrospective study analyzed 360 cases with NME on MRI images. Two breast radiologists independently evaluated each lesion using the Kaiser score (KS) and apparent diffusion coefficient (ADC) values, without knowledge of the pathological outcomes. NME lesions with a KS above 4 and an ADC value below 1.3 × 10-3mm2/s were classified as malignant. Inter-rater reliability was determined using Cohen's Kappa (κ) statistics. The diagnostic performance of KS, DWI, and their combination was assessed by calculating sensitivity, specificity, and the area under the curve (AUC), and the results were compared across the benign and malignant groups. The diagnostic performance of KS surpassed that of DWI in predicting the malignancy of NMEs (p = 0.003). The sensitivity of KS alone was 93 %; however, when ADC data was incorporated, the sensitivity decreased to 86 %, with no significant difference observed (p = 0.060). The specificity of the combined KS and ADC (94 %) was significantly higher than that of KS alone (89 %) and DWI alone (73 %) (p < 0.001). Our findings indicated that although the combination of KS and ADC increased specificity and reduced unnecessary biopsies, the resulting decrease in sensitivity was unacceptable. Therefore, KS alone is superior to the KS-ADC combination in detecting malignancy in NME lesions.

Coskun Bilge A ，Aydin H 《-》

Diagnostic Performance of Kaiser score in MRI BI-RADS 3 Lesions: A Promising tool to reduce unnecessary biopsies.

To evaluate the possibility of reducing unnecessary biopsies in patients with BI-RADS 3 lesions by implementing Kaiser score (KS). In this retrospective, single-center study, we included 79 female patients with BI-RADS 3 lesions and risk factors who underwent biopsy following magnetic resonance imaging. Three readers (two experienced breast radiologists and a radiology resident) blinded evaluated the lesions using KS. Lesions with a KS ≤ 4 were considered benign. Results were compared with the histopathological findings (gold standard) assessing sensitivity and specificity along with 95 % confidence intervals (CI) for each reader. Inter-reader agreement was assessed using Fleiss' kappa with 95 % CIs. Moreover, Cohen's kappa was used to assess concordance between two readers at time. 79 female patients (mean age, 50.9 ± 12.2 (standard deviation)) were evaluated. The area under the receiver operating characteristic curve for the three readers was excellent: 0.99, 0.99, and 0.90), respectively. The sensitivity of the two breast radiologists and the resident was 0.92 (95 % CI: 0.62 - 0.99), 1.00 (95 % CI: 0.95 - 1.00) and 0.75 (95 % CI: 0.42 - 0.95), respectively, while the specificity was 1.00 (95 % CI: 0.95---1.00), 0.99 (95 % CI: 0.92 - 1.00), and 1.00 (95 % CI: 0.95 - 1.00) respectively. By using a KS ≤ 4 value to indicate benignity, 66 to 67 biopsies (84 to 85 % of all the biopsies) would have been avoided. Inter-reader concordance via Fleiss' kappa was 0.792 (95 % CI: 0.68 - 0.91). The implementation of KS could have spared 84-85% of biopsies, proving to be a quick, user-friendly tool with strong inter-observer agreement and high specificity.

Ostillio E ，Carriero S ，Razzini D ，Groenhoff L ，Tambasco A ，Airoldi C ，Clelia Gambaro AL ，Carriero A ，Costantini P ... -  《-》