Value of triglyceride glucose-body mass index in predicting nonalcoholic fatty liver disease in individuals with type 2 diabetes mellitus.

There is limited data on the association between TyG-BMI and NAFLD in patients with Type 2 Diabetes Mellitus (T2DM). The magnitude of risk prediction and predictive efficacy of TyG-BMI for T2DM with NAFLD remains unclear. To examine the association of TyG-BMI with NAFLD in T2DM patients and assess the effectiveness of screening using the TyG-BMI index. We conducted a retrospective analysis of clinical data from 602 T2DM patients at an enterprise health lodge from September 2021 to November 2022. Patients were categorized into two groups: T2DM alone (n=250) and T2DM with NAFLD (n=352). The Mann-Whitney U test was used for comparing non-normally distributed continuous data between groups, while the Chi-square test was used for categorical data. Logistic regression analysis was performed to evaluate the effect of BMI, TyG index, and TyG-BMI index on NAFLD. The ROC curve was used to assess the predictive efficacy of the TyG-BMI index for NAFLD in T2DM patients. BMI predicted the development of NAFLD in T2DM patients with an area under the receiver operating characteristic (ROC) curve of 0.792 (95% CI 0.757-0.828), and the optimal cutoff value was 25.22, with 72.2% sensitivity and 71.6% specificity; The area under the receiver operating characteristic (ROC) curve of the TyG index to predict the development of NAFLD in patients with T2DM was 0.755 (95% CI 0.716-0.794), and the optimal cutoff value was 8. 945, with a sensitivity of 80.1% and a specificity of 59.2%; The area under the receiver operating characteristic (ROC) curve of TyG-BMI index to predict the development of NAFLD in T2DM patients was 0.852, (95% CI 0.822-0.882), and the optimal cutoff value was 227.385, with a sensitivity and specificity of 80.1% and 59.2%, respectively. The TyG-BMI index is a significant predictor of comorbid NAFLD in T2DM patients and provides better screening performance than BMI alone. The TyG-BMI index shows promise as an early screening tool for NAFLD in T2DM patients.

Qian X ，Wu W ，Chen B ，Zhang S ，Xiao C ，Chen L ，Chen J ，Ke L ，He M ，Li X ... -  《Frontiers in Endocrinology》

The potential of insulin resistance indices to predict non-alcoholic fatty liver disease in patients with type 2 diabetes.

The triglyceride-glucose (TyG) index and related parameters, as well as the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), have been developed as insulin resistance markers to identify individuals at risk for non-alcoholic fatty liver disease (NAFLD). However, its use for predicting NAFLD in patients with type 2 diabetes mellitus (T2DM) remains unclear. In this study, we aimed to observe the performance of insulin resistance indices in diagnosing NAFLD combined with T2DM and to compare their diagnostic values in clinical practice. Overall, 268 patients with T2DM from the Endocrinology Department of Jiangsu Provincial Hospital of Traditional Chinese Medicine were enrolled in this study and divided into two groups: an NAFLD group (T2DM with NAFLD) and a T2DM group (T2DM without NAFLD). General information and blood indicators of the participants were collected, and insulin resistance indices were calculated based on these data. Receiver operating characteristic (ROC) analysis was conducted to calculate the area under the curve (AUC) for insulin resistance-related indices, aiming to assess their ability to discriminate between T2DM patients with and without NAFLD. ROC analysis revealed that among the five insulin resistance-related indices, four parameters (TyG, TyG-body mass index [BMI], TyG-waist circumference [WC], and TyG- (waist-hip ratio [WHR]) exhibited high predictive performance for identifying NAFLD, except for HOMA-IR (AUCs:0.710,0.738,0.737 and 0.730, respectivly). TyG-BMI demonstrated superior predictive value, especially in males. For males, the AUC for TyG-BMI was 0.764 (95% confidence interval [CI] 0.691-0.827). The sensitivity and specificity for male NAFLD were 90.32% and 47.89%, respectively. Moreover, in the Generalized linear regression models, there were positive associations of TyG, TyG-BMI, TyG-WC, TyG-WHR, and HOMA-IR with controlled attenuation parameter (CAP), with β values of 21.30, 0.745, 0.247, and 2.549 (all P < 0.001), respectively. TyG-BMI is a promising predictor of NAFLD combined with T2DM, particularly in lean male patients.

Tian J ，Cao Y ，Zhang W ，Wang A ，Yang X ，Dong Y ，Zhou X ... -  《BMC Endocrine Disorders》

Association between triglyceride glucose-body mass index and non-alcoholic fatty liver disease in the non-obese Chinese population with normal blood lipid levels: a secondary analysis based on a prospective cohort study.

Li Y ，Zheng R ，Li J ，Feng S ，Wang L ，Huang Z ... -  《Lipids in Health and Disease》

Association between triglyceride glucose-body mass index and the staging of non-alcoholic steatohepatitis and fibrosis in patients with non-alcoholic fatty liver disease.

Zhang F ，Han Y ，Wu Y ，Bao Z ，Zheng G ，Liu J ，Li W ... -  《-》

[Triglyceride-glucose index in non-obese individuals: its association with and predictive value for non-alcoholic fatty liver disease].

Xiao J ，Li Y ，Fang M ，Gong H ，Li W ，Zhang C ，Chen F ，Zhang Y ，Han T ... -  《-》