Impact of different staging methods of lymph nodes metastases on prognosis in advanced hypopharyngeal squamous cell carcinoma.

Lymph node ratio (LNR), log odds of positive lymph nodes (LODDS), and the number of postoperative lymph node staging (pN) are prognostic indicators of various cancers. However, the prognostic values of these indicators remain unclear in hypopharyngeal squamous cell carcinoma (HPSCC). This study's primary objective was to investigate the predictive value of LNR, LODDS, and pN for advanced HPSCC, and the secondary objective was to compare which of the values had the best predictive value for advanced HPSCC. A retrospective study was conducted on 166 patients with stage Ⅲ-Ⅳ HPSCC. LNR and LODDS were divided into two groups according to the defined cut-off values. Univariate and multivariate analyses on the risk of overall survival (OS) and progression-free survival (PFS) were performed, respectively. The predictive value of LNR was compared with that of LODDS and pN using receiver operating characteristic (ROC) curves. According to the X-tile, the cut-off values are 0.11 for LNR and -0.91 for LODDS. LNR, LODDS, and pN were significantly correlated with PFS by univariate analysis (p < 0.05). Multivariate analysis demonstrated that LNR was an independent prognostic factor for PFS (p < 0.01). Multivariate analysis also revealed that postoperative tumor staging (pT) classification (p = 0.003), LNR (p = 0.029), and surgical margins (p = 0.001) were independent prognostic factors for OS. LNR was demonstrated as an independent prognostic factor for PFS, other than LODDS and pN. LNR was an independent predictor for OS and PFS for advanced HPSCC.

Wang T ，Zhang D ，Hsueh C ，Lau HC ，Tao L ，Wu C ... -  《-》

Prognostic value of log odds of positive lymph nodes in patients with resectable oral squamous cell carcinoma.

Log odds of positive lymph nodes (LODDS) was reported to be significantly associated with prognosis in several malignant tumors. However, few are the studies on the correlation between LODDS and overall survival (OS) in patients with oral squamous cell carcinoma (OSCC). A retrospective study including 233 patients with OSCC during 2009 to 2013 was conducted. We probed the correlation between clinicopathological factor, LODDS, lymph node ratio (LNR), pN and OS. The potential prognostic factor and the independent factor were calculated using univariate analysis and multivariate analysis respectively. The goodness of fit and the discriminability was analyzed with Somer's D value, Nagelkerke R2 index, and Akaike information criterion (AIC). Kaplan-Meier survival curve of OS was contrasted by log-rank test in LODDS, LNR and pN, respectively. According to the X-tile, the cut-off values are -1.491 and -0.763 for LODDS, 0.024 and 0.133 for LNR. LODDS, LNR and pN were significantly correlated with OS by univariate analysis (P < 0.001). Multivariate analysis demonstrated LODDS, LNR and pN as an independent prognostic factors for OS (P < 0.01). Compared with pN and LNR models, LODDS showed the strongest predictive power. LODDS was superior to LNR and pN in predicting outcomes in patients with no positive lymph nodes and inadequate neck dissection. LODDS would be incorporated into future N classification, which may be conducive to discern the prognosis of OSCC and make a decision of adjuvant therapy in clinical practice.

Jin W ，Zhu Z ，Wu Y ，Ding X ，Wu H ，Song X ，Wu Y ... -  《-》

Prognostic value of three different lymph node staging systems in the survival of patients with gastric cancer following D2 lymphadenectomy.

Jian-Hui C ，Shi-Rong C ，Hui W ，Si-le C ，Jian-Bo X ，Er-Tao Z ，Chuang-Qi C ，Yu-Long H ... -  《-》

Prognostic assessment of different lymph node staging methods for pancreatic cancer with R0 resection: pN staging, lymph node ratio, log odds of positive lymph nodes.

Survival after surgical resection of pancreatic adenocarcinoma is poor. Several prognostic factors such as the status of the resection margin, lymph node status, or tumour grading have been identified. The aims of the present study were to evaluate and compare the prognostic assessment of different lymph nodes staging methods: standard lymph node (pN) staging, metastatic lymph node ratio (LNR), and log odds of positive lymph nodes (LODDS) in pancreatic cancer after pancreatic resection. Data were retrospectively collected from 143 patients who had undergone R0 pancreatic resection for pancreatic ductal adenocarcinoma. Survival curves (Kaplan-Meier and Cox proportional hazard models), accuracy, and homogeneity of the 3 methods (LNR, LODDS, and pN) were compared to evaluate the prognostic effects. Multivariate analysis demonstrated that LODDS and LNR were an independent prognostic factors, but not pN classification. The scatter plots of the relationship between LODDS and the LNR suggested that the LODDS stage had power to divide patients with the same ratio of node metastasis into different groups. For patients in each of the pN or LNR classifications, significant differences in survival could be observed among patients in different LODDS stages. LODDS and LNR are more powerful predictors of survival than the lymph node status in patients undergoing pancreatic resection for ductal adenocarcinoma. LODDS allows better prognostic stratification comparing LNR in node negative patients.

La Torre M ，Nigri G ，Petrucciani N ，Cavallini M ，Aurello P ，Cosenza G ，Balducci G ，Ziparo V ，Ramacciato G ... -  《-》

[The relationship between the index of lymph node metastasis and the prognosis of pancreatic cancer patients after R0 resection].

Ren H ，Wang CF 《-》