Cardiac biomarker profiles in dogs with naturally occurring precapillary pulmonary hypertension.
This study evaluated circulating amino-terminal pro-B-type natriuretic peptide (NT-proBNP), amino-terminal pro-A-type natriuretic peptide (NT-proANP), and cardiac troponin I (cTnI) concentrations in dogs with precapillary pulmonary hypertension (Pre-PH) and control dogs with respiratory clinical signs but no Pre-PH.
Twenty-six dogs (17 affected, and nine controls) were involved in the study.
This was a sub-study of a large prospective single-center observational study. Dogs underwent blood sample collection, physical examination, and echocardiographic evaluation. Precapillary pulmonary hypertension was diagnosed when a calculated right ventricular-to-right atrial pressure gradient (RV:RA PG) measuring ≥40 mmHg was identified echocardiographically, barring right ventricular outflow obstruction and/or left-sided cardiac disease.
Two, nine, and six dogs had mild, moderate, and severe Pre-PH, respectively. Plasma concentrations of NT-proBNP, NT-proANP, and cTnI were significantly higher in the affected group than in the control group (P=0.020, P=0.009, P=0.011, respectively). There was a positive correlation between RV:RA PG and NT-proBNP (r = 0.52), NT-proANP (r = 0.54), and cTnI (r = 0.67) concentrations.
Precapillary pulmonary hypertension should be included in the differential diagnosis list of elevated cardiac biomarker concentrations in dogs with respiratory signs.
Strict selection criteria reduced group sizes. There were rare missing data points. The diagnosis of Pre-PH was obtained from Doppler echocardiographic RV:RA PG. The disease process causing Pre-PH was not evaluated histopathologically.
Circulating cardiac biomarker concentrations are increased in dogs with Pre-PH and there is a positive correlation between RV:RA PG and NT-proBNP, NT-proANP, and cTnI concentrations.
Lichtenberger J
，Côté E
，Forney SD
，Barrett KA
，Ettinger SJ
... -
《-》
The expression of MALAT1, plasma brain natriuretic peptide, and Tei index in sepsis-induced myocardial injury.
We sought to investigate the expression of MALAT1, plasma brain natriuretic peptide, and Tei index in sepsis-induced myocardial injury.
The current retrospective analysis focused on 146 sepsis patients admitted to our hospital from February 2021 to March 2023. Based on the presence or absence of myocardial injury, the patients were divided into two groups: the sepsis group (n = 80) and the sepsis-induced myocardial injury group (n = 66). Based on the 28-day mortality status of the patients, they were also divided into a survival group of 143 cases and a death group of 3 cases. The study compared the levels of MALAT1, plasma brain natriuretic peptide, and Tei index between the sepsis group and sepsis-induced myocardial injury group, as well as the comparison of two sets of ultrasound indicators. Univariate logistic regression analysis was performed to identify the influencing factors of sepsis-induced myocardial injury, followed by multivariate logistic regression analysis to identify the influencing factors of such condition. MALAT1, plasma brain natriuretic peptide and cardiac Tei index between the survival and death groups were compared and Pearson correlation analysis was conduct to assess their correlations.
In terms of general information, there were no significant differences in gender, age, BMI, mean arterial pressure, systolic pressure, diastolic pressure, respiratory rate, oxygenation index, basic diseases and infection site between the two groups (P > 0.05). However, significant differences were observed in heart rate, SOFA score, and APACHE II score between the two groups (P < 0.05). The levels of MALAT1, plasma brain natriuretic peptide, and Tei index in the sepsis-induced myocardial injury group were significantly higher than those in the sepsis group (P < 0.05). Furthermore, the sepsis-induced myocardial injury group exhibited lower left ventricular end-diastolic diameter and left ventricular end-systolic diameter compared to the sepsis group, along with higher levels of E, E/e', and e', showing significant differences (P < 0.05). The independent variables considered in the analysis included general data, ultrasound indicators with significant differences, as well as MALAT1, plasma brain natriuretic peptide, and Tei index. The dependent variable was sepsis-induced myocardial injury, and univariate logistic regression analysis identified E, E/e', e', MALAT1, plasma brain natriuretic peptide, and Tei index as influencing factors of sepsis-induced myocardial injury. Subsequently, a multivariate logistic regression analysis was conducted with the independent variables set as E, E/e', e', MALAT1, plasma brain natriuretic peptide, and Tei index, and the dependent variable as sepsis-induced myocardial injury. The results indicated that MALAT1, plasma brain natriuretic peptide, and Tei index were influencing factors of sepsis-induced myocardial injury. The levels of MALAT1, plasma brain natriuretic peptide and cardiac Tei index in the death group were significantly higher than those in the survival group (P < 0.05). The Pearson correlation analysis showed that MALAT1, plasma brain natriuretic peptide and cardiac Tei index were correlated with the prognosis of patients with sepsis-induced myocardial injury (P < 0.05).
We demonstrated high expression levels of MALAT1, plasma brain natriuretic peptide, and Tei index in patients with sepsis-induced myocardial injury. Ultrasound indicators can effectively contribute to the diagnosis of sepsis-induced myocardial injury. Moreover, MALAT1, plasma brain natriuretic peptide, and Tei index have been identified as influencing factors of sepsis-induced myocardial injury.
Huang G
，Yang W
，Zhao X
，Bai Y
，Jiang X
，Liu J
... -
《Journal of Cardiothoracic Surgery》
The Role of Natriuretic Peptides in Pericardial Fluid in Predicting Cardiovascular Disorders: A Systematic Review.
Atrial and ventricular natriuretic peptides play an important role in the neurohormonal regulation of cardiac function. Plasma levels of these peptides may aid in the diagnosis and prognosis of different cardiac disorders, such as congestive heart failure, ischemic heart disease, and atrial fibrillation. However, the association between elevated pericardial fluid levels of natriuretic peptides and these clinical conditions has not been proven. Databases Medline, EMBASE, Cochrane, ClinicalTrials.gov, and Google Scholar were searched for primary studies evaluating atrial natriuretic peptide, B-type natriuretic peptide, and N-terminal-pro-B-type natriuretic peptide concentrations within the pericardial fluid in various cardiac disorders. A total of 1060 citations were screened, of which 38 studies underwent a full-text evaluation, and 10 were finally included in this review. Sample size varied across studies (n = 8-148), and there was a total of 577 patients across the 10 studies. Findings suggested that pericardial fluid levels of B-type natriuretic peptide and N-terminal-pro-B-type natriuretic peptide but not atrial natriuretic peptide, may correlated with the reported cardiac conditions. Our findings suggest that pericardial fluid levels of natriuretic peptides may correlate with some cardiac disorders such as congestive heart failure and atrial fibrillation. The addition of these peptides to the existing clinical risk stratification scores may be helpful in the early diagnosis and management of these conditions.
El-Sherbini AH
，Zucker J
，Sartor C
，Liblik K
，Cherif IA
，Hassanabad AF
，Fernandez AL
，El-Diasty M
... -
《-》
Brain natriuretic peptide and N-terminal pro b-type natriuretic peptide in kidney transplantation: More than just cardiac markers.
Although kidney transplantation (KT) is the best treatment option for most patients with end-stage kidney disease (ESKD) due to reduced mortality, morbidity and increased quality of life, long- term complications such as chronic kidney allograft dysfunction (CKAD) and increased cardiovascular disease burden are still major challenges. Thus, routine screening of KT recipients (KTRs) is very important to identify and quantify risks and guide preventative measures. However, no screening parameter has perfect sensitivity and specificity, and there is unmet need for new markers. In this review, we evaluate brain natriuretic peptide (BNP) and N-terminal pro b-type natriuretic peptide (NT-proBNP) as promising markers for risk stratification in the kidney transplant recipients (KTRs). The usefulness of these markers are already proven in heart failure, hypertension, coronary artery disease. In the context of KT, evidence is emerging. BNP and NT-proBNP has shown to be associated with kidney function, graft failure, echocardiographic parameters, major cardiovascular events and mortality but the underlying mechanisms are not known. Although BNP and NT-proBNP interact with immune system, renin angiotensin system and sympathetic system; it is not known whether these interactions are responsible for the clinical findings observed in KTRs. Future studies are needed whether these biomarkers show clinical efficacy, especially with regard to hard outcomes such as major adverse cardiovascular events and graft dysfunction and whether routine implementation of these markers are cost effective in KTRs.
Afsar B
，Afsar RE
，Caliskan Y
，Lentine KL
... -
《-》
ResearchGate
(全网免费下载)
钛学术
(全网免费下载)
