The impact of patellofemoral joint diseases on functional outcomes and prosthesis survival in patients undergoing unicompartmental knee arthroplasty: a systematic review and meta-analysis.
Patellofemoral joint (PFJ) diseases are chronic degenerative conditions that contribute to knee joint symptoms. Unicompartmental knee arthroplasty (UKA) is widely regarded as an effective treatment for knee osteoarthritis (KOA); however, its specific indications remain a subject of debate.
Patients with PFJ disease are expected to experience outcomes post-UKA comparable to those of patients without PFJ disease.
We conducted this meta-analysis following the guidelines outlined by the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA). A comprehensive search of PubMed, Embase, and Web of Science databases was conducted for studies examining the association between PFJ disease and UKA, including publications up to September 2024. Extracted data encompassed author, publication year, country, disease type, prosthesis type, sample size, mean patient age, gender distribution, follow-up duration, PFJ disease prevalence at surgery, diagnostic methods, and whether PFJ disease was considered a contraindication for UKA. To maintain objectivity, only studies in which PFJ diseases were visually identifiable were included in the meta-analysis. Statistical analyses were performed using Stata 15.0 and Review Manager 5.4.1. A random-effects meta-analysis was conducted to evaluate the Oxford Knee Score (OKS), Knee Society Score (KSS), flexion range of motion (ROM), Forgotten Joint Score (FJS), Tegner activity score, and prosthesis survival rate, with outcomes stratified by PFJ disease type (PFJ degeneration or patella cartilage injury). Mean differences, confidence intervals, and P values were calculated for comparisons between the PFJ disease and non-PFJ disease groups. The Methodological Index for Non-Randomized Studies (MINORS) criteria and the Newcastle-Ottawa Scale (NOS) were applied to evaluate the risk of bias. To address heterogeneity, sensitivity analyses were performed, and publication bias was assessed using funnel plots and Egger's test.
A total of 14,866 knees from 48 relevant studies were included in this systematic review. Methodological quality was assessed using the MINORS criteria, with case series scoring 11.0/16 and cohort studies scoring 18.2/24. PFJ degeneration emerged as the most studied condition, followed by patella cartilage injury. Clinical outcomes assessments indicated that medial PFJ degeneration, anterior knee pain, patella cartilage damage, and patella baja did not significantly impact UKA outcomes or prosthesis survival. However, severe lateral PFJ degeneration, lateral patellar subluxation, lateral trochlear osteophytes, and patellar bone marrow edema did influence results. Fifteen high-quality studies were included in the meta-analysis, involving 6080 patients-1338 in the PFJ disease group and 4,742 in the non-PFJ disease group. With an average NOS score of 7.2, the studies were generally of high quality. Meta-analysis results showed no significant differences between groups in final follow-up OKS, FJS, Tegner activity score, or prosthesis survival rate. However, the PFJ disease group had lower KSS and reduced flexion ROM compared to the non-PFJ disease group. Subgroup analysis further revealed that the PFJ degeneration group scored lower than the patella cartilage injury group on OKS, KSS, and flexion ROM following UKA.
In summary, PFJ disease was found to have limited impact on UKA outcomes; however, caution is recommended for cases involving severe lateral PFJ degeneration due to potential restrictions in postoperative knee function, particularly affecting flexion ROM in UKA patients.
Yang J
，Li X
，Liu P
，Liu X
，Li L
，Zhang M
... -
《Journal of Orthopaedic Surgery and Research》
Magnetic Resonance Imaging-Defined Osteoarthritis Features and Anterior Knee Pain in Individuals With, or at Risk for, Knee Osteoarthritis: A Multicenter Study on Osteoarthritis.
The lack of strong association between knee osteoarthritis (OA) structural features and pain continues to perplex researchers and clinicians. Evaluating the patellofemoral joint in addition to the tibiofemoral joint alone has contributed to explaining this structure-pain discordance, hence justifying a more comprehensive evaluation of whole-knee OA and pain. The present study, therefore, was undertaken to evaluate the association between patellofemoral and tibiofemoral OA features with localized anterior knee pain (AKP) using 2 study designs.
Using cross-sectional data from the Multicenter Osteoarthritis Study, our first approach was a within-person, knee-matched design in which we identified participants with unilateral AKP. We then assessed magnetic resonance imaging (MRI)-derived OA features (cartilage damage, bone marrow lesions [BMLs], osteophytes, and inflammation) in both knees and evaluated the association of patellofemoral and tibiofemoral OA features to unilateral AKP. In our second approach, MRIs from 1 knee per person were scored, and we evaluated the association of OA features to AKP in participants with AKP and participants with no frequent knee pain.
Using the first approach (n = 71, 66% women, mean ± SD age 69 ± 8 years), lateral patellofemoral osteophytes (odds ratio [OR] 5.0 [95% confidence interval (95% CI) 1.7-14.6]), whole-knee joint effusion-synovitis (OR 4.7 [95% CI 1.3-16.2]), and infrapatellar synovitis (OR 2.8 [95% CI 1.0-7.8]) were associated with AKP. Using the second approach (n = 882, 59% women, mean ± SD age 69 ± 7 years), lateral and medial patellofemoral cartilage damage (prevalence ratio [PR] 2.3 [95% CI 1.3-4.0] and PR 1.9 [95% CI 1.1-3.3], respectively) and lateral patellofemoral BMLs (PR 2.6 [95% CI 1.5-4.7]) were associated with AKP.
Patellofemoral but not tibiofemoral joint OA features and inflammation were associated with AKP.
Macri EM
，Neogi T
，Jarraya M
，Guermazi A
，Roemer F
，Lewis CE
，Torner JC
，Lynch JA
，Tolstykh I
，Jafarzadeh SR
，Stefanik JJ
... -
《-》
Morphological and Quantitative Parametric MRI Follow-up of Cartilage Changes Before and After Intra-articular Injection Therapy in Patients With Mild to Moderate Knee Osteoarthritis: A Randomized, Placebo-Controlled Trial.
Intra-articular injections are routinely used for conservative treatment of knee osteoarthritis (OA). The detailed comparative therapeutic effects of these injections on cartilage tissue are still unclear.
The aim of this study was to detect and compare knee cartilage changes after intra-articular injection of glucocorticoid, hyaluronic acid, or platelet-rich plasma (PRP) to placebo using quantitative (T2 and T2* mapping) and morphological magnetic resonance imaging parameters in patients with mild or moderate osteoarthritis.
In a double-blinded, placebo-controlled, single-center trial, knees with mild or moderate osteoarthritis (Kellgren-Lawrence grade 1-3) were randomly assigned to an intra-articular injection with 1 of these substances: glucocorticoid, hyaluronic acid, PRP, or placebo. Cartilage degeneration on baseline and follow-up magnetic resonance imaging scans (after 3 and 12 months) was assessed by 2 readers using quantitative T2 and T2* times (milliseconds) and morphological parameters (modified Outerbridge grading, subchondral bone marrow edema, subchondral cysts, osteophytes).
One hundred twenty knees (30 knees per treatment group) were analyzed with a median patient age of 60 years (interquartile range, 54.0-68.0 years). Interreader reliability was good for T2 (ICC, 0.76; IQR, 0.68-0.83) and T2* (ICC, 0.83; IQR, 0.76-0.88) measurements. Morphological parameters showed no significant changes between all groups after 3 and 12 months. T2 mapping after 12 months showed the following significant ( P = 0.001-0.03) changes between groups in 6 of 14 compartments: values after PRP injection decreased compared with glucocorticoid in 4 compartments (complete medial femoral condyle and central part of lateral condyle) and compared with placebo in 2 compartments (anterior and central part of medial tibial plateau); values after glucocorticoid injection decreased compared with placebo in 1 compartment (central part of medial tibial plateau). No significant changes were seen for T2 and T2* times after 3 months and T2* times after 12 months. No correlation was found between T2/T2* times and Kellgren-Lawrence grade, age, body mass index, or pain (Spearman ρ, -0.23 to 0.18).
Platelet-rich plasma injection has a positive long-term effect on cartilage quality in the medial femoral compartment compared to glucocorticoid, resulting in significantly improved T2 values after 12 months. For morphological cartilage parameters, injections with glucocorticoid, PRP, or hyaluronic acid showed no better effect in the short or long term compared with placebo.
Tschopp M
，Pfirrmann CWA
，Brunner F
，Fucentese SF
，Galley J
，Stern C
，Sutter R
，Catanzaro S
，Kühne N
，Rosskopf AB
... -
《-》
Heterogeneity of cartilage damage in Kellgren and Lawrence grade 2 and 3 knees: the MOST study.
Eligibility for clinical trials in osteoarthritis (OA) is usually limited to Kellgren-Lawrence (KL) grades 2 and 3 knees. Our aim was to describe the prevalence and severity of cartilage damage in KL 2 and 3 knees by compartment and articular subregion.
The Multicenter Osteoarthritis (MOST) study is a cohort study of individuals with or at risk for knee OA. All baseline MRIs with radiographic disease severity KL2 and 3 were included. Knee MRIs were read for cartilage damage in 14 subregions. We determined the frequencies of no, any and widespread full-thickness cartilage damage by knee compartment, and the prevalence of any cartilage damage in 14 articular subregions.
665 knees from 665 participants were included (mean age 63.8 ± 7.9 years, 66.5% women). 372 knees were KL2 and 293 knees were KL3. There was no cartilage damage in 78 (21.0%) medial tibio-femoral joint (TFJ), 157 (42.2%) lateral TFJ and 62 (16.7%) patello-femoral joint (PFJ) compartments of KL2 knees, and 17 (5.8%), 115 (39.3%) and 35 (12.0%) compartments, respectively, of KL3 knees. There was widespread full-thickness damage in 94 (25.3%) medial TFJ, 36 (9.7%) lateral TFJ and 176 (47.3%) PFJ compartments of KL2 knees, and 217 (74.1%), 70 (23.9%) and 104 (35.5%) compartments, respectively, of KL3 knees. The subregions most likely to have any damage were central medial femur (80.5%), medial patella (69.8%) and central medial tibia (69.9).
KL2 and KL3 knees vary greatly in cartilage morphology. Heterogeneity in the prevalence, severity and location of cartilage damage in in KL2 and 3 knees should be considered when planning disease modifying trials for knee OA.
Roemer FW
，Felson DT
，Stefanik JJ
，Rabasa G
，Wang N
，Crema MD
，Neogi T
，Nevitt MC
，Torner J
，Lewis CE
，Peloquin C
，Guermazi A
... -
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ResearchGate
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