Hepatitis Delta Virus Surveillance Practice among Clinicians in Nigeria: A Cross-Sectional Survey.

The near total absence of routine Hepatitis Delta Virus (HDV) screening in many countries in sub-Saharan Africa is a major challenge to understanding the burden of HDV in the region. To evaluate Hepatitis Delta Virus screening practices and associated factors among clinicians in Nigeria. A cross-sectional study was conducted in June-July 2022, in which a self-administered questionnaire that inquired about HDV awareness, screening practices, and treatment options was shared electronically with consenting clinicians practicing in Nigeria. At the end of the survey, data was analyzed using descriptive and inferential statistics. The level of significance was set at 0.05. At the end of the survey, 210 of the 213 responses retrieved from respondents were analyzed. The respondent's mean age was 38.60 ± 7.27 years with a male-to-female ratio of 1:2.5. They comprised 13.8% gastroenterologists and 86.2% respondents in other areas of clinical medicine. The study showed that 89.5% of the respondents knew that HDV infection occurs only in hepatitis B virus (HBV)-infected individuals. Most (91.4%) respondents do not screen for HDV in chronic HBV patients, mainly due to the non-availability of screening tools and lack of awareness of any screening test for HDV. Research interest was reported as the reason for screening among clinicians who had ever screened for HDV. Pegylated interferon was the main regimen used for treatment by 87.5% of respondents. About 2% did not know treatment options for HDV. A significant association between knowledge of HDV infection and area of specialty, as well as the nature of medical practice was noted (P = 0.008 and 0.013, respectively). The study showed a high level of awareness of HDV dependency on HBV, for natural infection to occur. However, it documented very minimal HDV screening in clinical settings and factors affecting screening among clinicians.

Ifeorah IM ，Musa Y ，Abdulkareem LO ，Oguntoye OO ，Gideon OD ，Ogunwale AO ，Ogu CO ，Ariyo OE ... -  《Nigerian Journal of Clinical Practice》

Addressing hepatitis delta in primary care practices in the US: a narrative review.

Kushner T ，Andrews RR 《-》

Seroprevalence of hepatitis B and delta viruses among HIV-infected population attending anti-retroviral clinic in selected health facilities in Abuja, Nigeria.

Ifeorah IM ，Bakarey AS ，Adeniji JA ，Onyemelukwe FN ... -  《-》

Growing Awareness: Limited Testing and Screening Bias for Hepatitis Delta Virus in Utah 2000-2021.

This study assessed the epidemiology of hepatitis delta virus (HDV) within the University of Utah UHealth health care system (2000-2021). Analysis of HDV/HBV testing, diagnostic codes, liver enzymes, and comorbidities was performed. Among the 1962 HBV patients, only 22.2% underwent HDV testing, revealing an 8.3% positivity rate for HDV coinfections. This study observed a consistent increase in HBV and HDV cases, with higher HDV detection rates linked to increased testing. Limited HDV testing and potential screening biases were evident. Improved HDV testing and surveillance are crucial for early detection and implementation of targeted therapies.

Hesterman MC ，Fallon BS ，Lynch KM ，Weller ML ... -  《-》

Molecular epidemiology of hepatitis D virus circulating in Southwestern Nigeria.

Opaleye OO ，Japhet OM ，Adewumi OM ，Omoruyi EC ，Akanbi OA ，Oluremi AS ，Wang B ，Tong Hv ，Velavan TP ，Bock CT ... -  《Virology Journal》