Coffee's protective mechanisms against neurodegeneration.

A widely consumed beverage, coffee has emerged as a potential protective natural agent against neurodegenerative diseases. This chapter explores the intricate mechanisms by which coffee and its bioactive compounds exert neuroprotective effects. The antioxidant properties of coffee polyphenols, such as chlorogenic acid and caffeic acid, mitigate oxidative stress and neuroinflammation. Coffee modulates neurotransmitter systems, including dopaminergic, cholinergic, and glutamatergic pathways implicated in neurodegeneration. Additionally, coffee activates neuroprotective signaling cascades, such as the Nrf2 pathway, and inhibits pro-inflammatory pathways like NF-κB. Coffee components also influence mitochondrial function, biogenesis, and energy metabolism, thereby promoting neuronal survival. Furthermore, coffee suppresses microglial activation and modulates microglial phenotypes, reducing neuroinflammatory responses. Epidemiological studies and clinical trials provide insights into the potential benefits of coffee consumption on cognitive function and neurodegenerative disease risk. However, future research should focus on identifying specific coffee bioactive compounds and their mechanism of action. This chapter highlights the multifaceted neuroprotective mechanisms of coffee, paving the way for future research and potential therapeutic interventions.

Raeis-Abdollahi E ，Raise-Abdullahi P ，Rashidy-Pour A ，Meamar M ，Askari H ... -  《-》

Coffee and amyotrophic lateral sclerosis (ALS).

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by progressive loss of motor neurons. The effective treatments for ALS remain elusive, necessitating exploration into novel preventive strategies. ALS pathogenesis is triggered by oxidative stress which results in neuroinflammation, exicitotoxicity and neuronal cell death. Nutritional mechanism for halting progression of neurodegeneration is through dietary compounds with antioxidants, anti-inflammatory or neuromodulating activity. Coffee is a widely consumed beverage made up of polyphenols, caffeine and other compounds with possible antioxidants and neuro-protective roles. It is important to say that various epidemiological studies have documented association between coffee intake and ALS. This chapter is aimed to present a comprehensive review of existing literature on coffee consumption and ALS, involving epidemiological studies, preclinical research, and its mechanism of actions in animal model of ALS. It highlights key findings regarding the potential neuroprotective properties of coffee constituents such as caffeine, polyphenols, and other bioactive compounds. Furthermore, it discusses possible pathways through which coffee may modulate ALS pathogenesis, including suppressing oxidative stress and neuroinflammation while boosting adenosine function via the adenosine receptor two on the motor neuron cells membrane in the spinal cord to enhance motor function via the corticospinal tract. Overall, this chapter underscores the significance of further research to unravel the specific mechanisms by which coffee exerts its neuroprotective effects in ALS, with the ultimate goal of identifying dietary strategies for ALS prevention and management.

Memudu AE ，Olukade BA ，Adebayo OS ，Raza ML ... -  《-》

Coffee, antioxidants, and brain inflammation.

Coffee is the most popular beverage in the world and, aside from tea and water, the most often consumed caffeine-containing beverage. Because of its high caffeine concentration, it is typically classified as a stimulant. There are other bioactive ingredients in coffee besides caffeine. The coffee beverage is a blend of several bioactive substances, including diterpenes (cafestol and kahweol), alkaloids (caffeine and trigonelline), and polyphenols (particularly chlorogenic acids in green beans and caffeic acid in roasted coffee beans). Caffeine has also been linked to additional beneficial benefits such as antioxidant and anti-inflammatory properties, which change cellular redox and inflammatory status in a dose-dependent manner. Pyrocatechol, a constituent of roasted coffee that is created when chlorogenic acid is thermally broken down, has anti-inflammatory properties as well. It is postulated that coffee consumption reduces neuroinflammation, which is intimately linked to the onset of neurodegenerative disorders like Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD). This review provides an overview of the most recent studies regarding coffee's possible benefits in preventing brain inflammation and neurodegenerative disorders.

Rai SP ，Ansari AH ，Singh D ，Singh S ... -  《-》

Roasted coffees high in lipophilic antioxidants and chlorogenic acid lactones are more neuroprotective than green coffees.

Chu YF ，Brown PH ，Lyle BJ ，Chen Y ，Black RM ，Williams CE ，Lin YC ，Hsu CW ，Cheng IH ... -  《-》

Neuroprotective Effects of Coffee Bioactive Compounds: A Review.

Socała K ，Szopa A ，Serefko A ，Poleszak E ，Wlaź P ... -  《INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES》