Subcortical white matter differences according to presence of disorders of consciousness in hypoxic-ischemic brain injury: a tract-based spatial statistics study.

We investigated differences in subcortical white matter according to the presence disorders of consciousness (DOC) in patients with hypoxic-ischemic brain injury (HI-BI), using tract-based spatial statistics (TBSS). Thirty-two consecutive patients with HI-BI were recruited. The patients were assigned in group A [preserved consciousness (Glasgow Coma Scale: 15 and Coma Recovery Scale-revised (CRS-R): 23, 9 patients)] or group B [DOC present (Glasgow Coma Scale <15 and CRS-R < 23, 20 patients)]. Voxel-wise statistical analysis of fractional anisotropy data was performed by using TBSS as implemented in the FMRIB Software Library. We calculated mean fractional anisotropy values across the white matter skeleton and within 48 regions of interest (ROIs) based on intersections between the skeleton and the probabilistic Johns Hopkins University white matter atlases. Among the 48 ROIs examined, the fractional anisotropy values of two ROIs (the left superior corona radiata, and left tapetum) were significantly lower in group B than in group A ( P  < 0.05). No significant differences were observed, however, in the other 46 ROIs ( P  > 0.05). Our results suggest that abnormalities of the superior corona radiata and tapetum may be critical for DOC presence in patients with HI-BI.

Jang SH ，Kwon HG 《-》

Correlation between Thalamocortical Tract and Default Mode Network with Consciousness Levels in Hypoxic-Ischemic Brain Injury Patients: A Comparative Study Using the Coma Recovery Scale-Revised.

Jang SH ，Yeo SS ，Cho MJ ，Chung WK ... -  《MEDICAL SCIENCE MONITOR》

Changes in subcortical white matter in the unaffected hemisphere following unilateral spontaneous intracerebral hemorrhage: a tract-based spatial statistics study.

Kwon YH ，Jang SH 《Journal of Integrative Neuroscience》

White Matter Abnormalities in Traumatic Subarachnoid Hemorrhage: A Tract-Based Spatial Statistics Study.

Kim MS ，Cho MJ ，Kim JW ，Jang SH ... -  《MEDICAL SCIENCE MONITOR》

White Matter Abnormalities in Spontaneous Subarachnoid Hemorrhage: A Tract-Based Spatial Statistics Study.

Lee SJ ，Kim MS ，Jang SH 《-》