Effects of Sacubitril/Valsartan on Survival in Patients with Heart Failure and Significant Valvular Heart Disease.

Although the benefits of sacubitril/valsartan in heart failure with reduced ejection fraction (HFrEF) are well established, patients with hemodynamically significant mitral regurgitation (MR) were excluded from pivotal trials. We aimed to assess the effects of sacubitril/valsartan on survival in patients with HFrEF and concomitant significant MR. All patients from a single center who underwent echocardiography between June 2008 and December 2020, with a left ventricular ejection fraction (LVEF) of less than 40% and hemodynamically significant MR were recruited. Patients were categorized according to drug use and year of the index echocardiogram into the angiotensin receptor/neprilysin inhibitor (ARNI), non-ARNI before 2017, and non-ARNI after 2017 groups. Patients in the ARNI and non-ARNI after 2017 groups were compared directly, whereas patients in the non-ARNI before 2017 group were matched to the ARNI group in a 3:1 ratio. The outcome of interest was all-cause mortality. Death was compared between the groups using univariate and multivariate Cox proportional hazard models. After exclusion by criteria and matching, there remained 610 patients in the ARNI group, 434 in the non-ARNI after 2017 group, and 1,722 in the non-ARNI before 2017 group. During follow-up, all-cause mortality was significantly lower in the ARNI group compared with both non-ARNI after 2017 and non-ARNI before 2017 groups. Multivariate analysis of both pairs of comparison between groups found the use of ARNI to be significantly associated with increased survival. In patients with HFrEF and concomitant significant MR, treatment with sacubitril/valsartan was associated with lower risks of all-cause death.

Lin DS ，Chao YT ，Chuang SL ，Lee JK ，Lin TT ，Lin LC ，Huang KC ，Hwang JJ ... -  《-》

Effects of sacubitril/valsartan on renal function and outcome in patients with heart failure and reduced ejection fraction: an Italian cohort study.

Palazzuoli A ，Pirrotta F ，Cartocci A ，Delcuratolo E ，Dini FL ，Correale M ，Dattilo G ，Masarone D ，Scelsi L ，Ghio S ，Tocchetti CG ，Mercurio V ，Brunetti ND ，Nodari S ，Barillà F ，Ambrosio G ，Carluccio E ... -  《-》

Comparison of the Efficacy and Safety of Sacubitril/Valsartan and Angiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Patients With Reduced Ejection Fraction Combined With Moderate-to-Severe Chronic Kidney Disease.

Zhang Z ，Chen S ，Xu X ，Luo G ，Huang J ... -  《-》

Effects of Sacubitril/Valsartan on All-Cause Hospitalizations in Heart Failure: Post Hoc Analysis of the PARADIGM-HF and PARAGON-HF Randomized Clinical Trials.

Lu H ，Claggett BL ，Packer M ，Lam CSP ，Swedberg K ，Rouleau J ，Zile MR ，Lefkowitz M ，Desai AS ，Jhund P ，McMurray JJV ，Solomon SD ，Vaduganathan M ... -  《-》

Sacubitril/Valsartan in Pediatric Heart Failure (PANORAMA-HF): A Randomized, Multicenter, Double-Blind Trial.

Shaddy R ，Burch M ，Kantor PF ，Solar-Yohay S ，Garito T ，Zhang S ，Kocun M ，Mao C ，Cilliers A ，Wang X ，Canter C ，Rossano J ，Wallis G ，Menteer J ，Daou L ，Kusa J ，Tokel K ，Dilber D ，Xu Z ，Xiao T ，Halnon N ，Daly KP ，Bock MJ ，Zuckerman W ，Singh TP ，Chakrabarti M ，Levitas A ，Senni M ，Grutter G ，Kim GB ，Song J ，Lee HD ，Chen CK ，Sanchez-de-Toledo J ，Law Y ，Wanitkun S ，Cui Y ，Anjos R ，Mese T ，Bonnet D ... -  《-》