Effectiveness of Agomelatine in Generalized Anxiety Disorder Comorbid to Bipolar 1 Disorder in a Male Adolescent Patient.

Anxiety comorbidity in bipolar disorder (BD) is important and thus significantly affects the course of BD and its outcomes. The treatment of generalized anxiety disorder comorbid with BD involves certain challenges, as antidepressant medications, which are standard in the treatment of anxiety disorder, have the risk of shifting to manic episodes and rapid cycling. In this case report, the response to agomelatine treatment in generalized anxiety disorder comorbid with bipolar 1 disorder was evaluated.

Kaçar A ，Karakuş OB ，Aydın ZE ，Adak İ ... -  《-》

Efficacy and Safety of Agomelatine in Depressed Patients with Diabetes: A Systematic Review and Meta-Analysis.

Gędek A ，Modrzejewski S ，Materna M ，Szular Z ，Wichniak A ，Mierzejewski P ，Dominiak M ... -  《INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES》

A Retrospective Analysis of the Impact of Electroconvulsive Therapy on Anxiety Symptoms in Patients With Treatment-Resistant Depression.

Electroconvulsive therapy (ECT) is an effective treatment for treatment-resistant depression (TRD). There are limited data on the improvement of anxiety symptoms in patients receiving ECT for TRD. The aim of the study was to examine the extent to which anxiety symptom severity improves, relative to improvements in depressive symptoms, in TRD patients receiving an acute course of ECT. A retrospective chart review of 117 TRD patients who received an acute ECT course in a naturalistic outpatient setting was conducted. Symptomatic response was measured using the Beck Depression Inventory II and Generalized Anxiety Disorder 7 Scale. Two generalized estimating equation models assessed the degree of change in anxious symptoms relative to the change in depressive symptoms. Both depression (-0.09, P < 0.001) and anxiety (-0.08, P < 0.001) improved after ECT treatment, with a greater standardized decrease for symptoms of depression. Higher levels of anxiety over the treatment (-0.42, P < 0.001) were associated with smaller antidepressant improvements. ECT may improve symptoms of anxiety in patients with TRD. Anxiety symptoms show a favorable trajectory of improvement, though to a lesser extent, relative to changes in symptoms of depression. Higher symptoms of anxiety throughout the treatment course may be a negative predictor of antidepressant response in ECT.

Laszcz J ，Wang C ，Riva-Posse P ，Kim J ，Tsygankova V ，Mandell A ，Rice H ，Hermida A ，Kitay BM ，Crowell A ，McDonald WM ，Hershenberg R ... -  《-》

Melatonin and agomelatine for preventing seasonal affective disorder.

Nussbaumer-Streit B ，Greenblatt A ，Kaminski-Hartenthaler A ，Van Noord MG ，Forneris CA ，Morgan LC ，Gaynes BN ，Wipplinger J ，Lux LJ ，Winkler D ，Gartlehner G ... -  《Cochrane Database of Systematic Reviews》

Exploring real-world prescribing patterns for maintenance treatment in bipolar disorders: a focus on antidepressants and benzodiazepines.

Andric Petrovic S ，Jankovic D ，Kaurin N ，Mandic Maravic V ，Pesic D ，Ristic I ，Maric NP ... -  《-》