Association Between Weight-Adjusted Waist Index and Cognitive Function in Older Adults Without Diabetes: A Cross-Sectional Study.
This study investigates the correlation between the weight-adjusted waist index (WWI) and cognitive performance in the senior American population, focusing on those without diabetes from 2011 to 2014.
We analyzed data from the 2011-2012 and 2013-2014 National Health and Nutrition Examination Surveys (NHANES), focusing on non-diabetic participants aged 60 and older who completed cognitive tests: Establish a Registry for Alzheimer's disease (CERAD), the Animal Fluency test (AFT), and Digit Symbol Substitution test (DSST). WWI was calculated using waist circumference divided by the square root of body weight. We employed linear univariate and multivariate analyses, along with curve fitting, we conducted subgroup and interaction analyses to elucidate the relationships under investigation.
The study incorporated a cohort of 1649 participants aged 60 years and older, each with a complete set of data, enabling a thorough analysis. After adjusting for confounding factors, significant negative correlations were found between WWI and both CERAD (β: -0.48; 95% CI: -0.92 to -0.05; P=0.03) and DSST (β: -1.15; 95% CI: -2.09 to -0.21; P=0.017) scores, suggesting a link to cognitive decline. No association was found with AFT scores. The relationship between WWI and DSST was found to be nonlinear (P for non-linearity=0.022). Additionally, the association between WWI and CERAD was also observed (P for non-linearity=0.042). However, linear relationships were observed between WWI and AFT (P for non-linearity=0.418). The subgroup analysis was overall stable.
Our cross-sectional study indicates a strong link between a high WWI and reduced cognitive function in non-diabetic older Americans, as shown by CERAD and DSST scores. Attaining an optimal WWI may be vital for cognitive decline, highlighting its role in a potential preventative approach.
The study design and data are publicly accessible at www.cdc.gov/nchs/nhanes/.
Wang Q
，Yin Y
，Liu W
，Li L
，Wang Z
，Tian Y
，Fan J
... -
《Clinical Interventions in Aging》
Association between weight-adjusted waist index and testosterone deficiency in adult American men: findings from the national health and nutrition examination survey 2013-2016.
Testosterone deficiency (TD) and obesity are globally recognized health concerns, with a bidirectional causal relationship between them. And a newly discovered obesity indicator, the Weight-Adjusted-Waist Index (WWI), has been proposed, demonstrating superior adiposity identification capability compared to traditional body mass index (BMI) and waist circumference (WC) indicators. Therefore, we present the inaugural investigation into the associations of WWI with total testosterone levels and the risk of TD.
Data restricted to the National Health and Nutrition Examination Survey (NHANES) between 2013 and 2016 were analyzed. Only males aged > 20 years who completed body measures and underwent serum sex hormone testing were potentially eligible for analysis. Weighted multivariable linear regression and logistic regression analyses were employed to investigate the relationships between WWI and total testosterone levels, and the risk of TD, respectively. Smooth curve fittings and weighted generalized additive model (GAM) regression were conducted to examine the linear relationship among them. Additionally, subgroup analyses with interaction tests were performed to assess the stability of the results.
Finally, a total of 4099 participants with complete data on testosterone and WWI were included in the formal analysis. The mean age of study participants was 46.74 ± 0.35 years with a TD prevalence of 25.54%. After adjusting all potential confounders, the continuous WWI displayed a negative linear relationship with total testosterone levels (β=-61.41, 95%CI: -72.53, -50.29, P < 0.0001) and a positive linear relationship with risk of TD (OR = 1.88, 95%CI: 1.47, 2.39, P < 0.0001). When WWI was transformed into quartiles as a categorical variable, participants in Q4 exhibited lower total testosterone levels (β=-115.4, 95%CI: -142.34, -88.45, P < 0.0001) and a higher risk of TD (OR = 3.38, 95% CI: 2.10, 5.44, P < 0.001). These associations remained stable in subgroup analyses without significant interaction (all P for interaction > 0.05).
This investigation firstly unveiled a negative linear association between WWI and total testosterone levels, coupled with a positive linear relationship with the prevalence of TD in U.S. male adults aged 20 years and older. Further studies are needed to validate the potential utility of WWI for the early identification and timely intervention of TD.
Liu D
，Li Y
，Ji N
，Xia W
，Zhang B
，Feng X
... -
《BMC PUBLIC HEALTH》
Association between four anthropometric indices with age-related Macular Degeneration from NHANES 2005-2008.
Age-related macular degeneration (AMD) decrease vision and presents considerable challenges for both public health and clinical management strategies. Obesity is usually implicated with increased AMD, and body mass index (BMI) does not reflect body fat distribution. An array of studies has indicated a robust relationship between body fat distribution and obesity. This research is to evaluate the relationship between anthropometric measurements and AMD in the United States citizens in a cohort of patients.
Our study included a cohort of 3,127 participants, all of whom were selected from the National Health and Nutrition Examination Survey (NHANES) conducted between 2005 and 2008. Various anthropometric indices, including weight (WT), waist circumference (WC), Body Mass Index (BMI), waist-to-height ratio (WtHR), circularity index (CI), weight-adjusted waist circumference index (WWI), body roundness index (BRI), a body size index (ABSI), and visceral adiposity index (VAI), have been studied extensively within public health and nutrition to assess body fat distribution. Odds ratios (OR) for each anthropometric index, in relation to AMD and its different stages, were computed, adjusting for confounding variables. Smoothed curve fitting, coupled with weighted multivariable logistic regression analysis, was used to examine the impact of these anthropometric measures on the prevalence of AMD. Subgroup analyses were conducted according to gender, age, BMI, drinking, smoking, CVD, diabetes, hypertension, cataract operation, and glaucoma.
After adjusting for all variables, significant positive correlations were observed between WtHR (OR = 1.237 (1.065-1.438)), BRI (OR = 1.221 (1.058-1.410)), CI (OR = 1.189 (1.039-1.362)), and WWI (OR = 1.250 (1.095-1.425)) with AMD, particularly for early AMD. However, no significant effects of these indicators were observed in late AMD. CI exhibited a positive linear relationship with AMD. Two-segment linear regression modeling revealed positive nonlinear associations between WtHR, BRI, and WWI with AMD. The positive association was more pronounced with excessive alcohol consumption for WtHR, BRI, CI, and WWI (P for interaction = 0.0033, 0.0021, 0.0194, and 0.0022, respectively). Additionally, WWI and CI exhibited stronger associations with AMD in females (P for interaction = 0.0146 and 0.0117, respectively). Furthermore, WtHR was associated with AMD in non-smokers (P for interaction = 0.0402).
This study confirmed a increased risk between four anthropometric measures, including WtHR, BRI, CI, and WWI, with AMD, especially early AMD. The findings suggest that these four anthropometric indices should be more broadly utilized to improve early AMD prevention and treatment strategies. Additionally, we found that the positive association between these four body measurement indices and AMD was more pronounced in individuals with high alcohol consumption.
Xu C
，Wu X
《Lipids in Health and Disease》
ResearchGate
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