Immunotherapy and radiotherapy for older patients with invasive bladder cancer unfit for surgery or chemotherapy: practical proposal by the international geriatric radiotherapy group.

The standard of care for non-metastatic muscle invasive bladder cancer is either radical cystectomy or bladder preservation therapy, which consists of maximal transurethral bladder resection of the tumor followed by concurrent chemoradiation with a cisplatin-based regimen. However, for older cancer patients who are too frail for surgical resection or have decreased renal function, radiotherapy alone may offer palliation. Recently, immunotherapy with immune checkpoint inhibitors (ICI) has emerged as a promising treatment when combined with radiotherapy due to the synergy of those two modalities. Transitional carcinoma of the bladder is traditionally a model for immunotherapy with an excellent response to Bacille Calmette-Guerin (BCG) in early disease stages, and with avelumab and atezolizumab for metastatic disease. Thus, we propose an algorithm combining immunotherapy and radiotherapy for older patients with locally advanced muscle-invasive bladder cancer who are not candidates for cisplatin-based chemotherapy and surgery.

Nguyen NP ，Karlsson UL ，Page BR ，Chirila ME ，Vinh-Hung V ，Gorobets O ，Arenas M ，Mohammadianpanah M ，Javadinia SA ，Giap H ，Kim L ，Dutheil F ，Murthy V ，Mallum AA ，Tlili G ，Dahbi Z ，Loganadane G ，Blanco SC ，Bose S ，Natoli E ，Li E ，Morganti AG ... -  《Frontiers in Oncology》

Immunotherapy and Radiotherapy for Older Patients with Locally Advanced Non-Metastatic Non-Small-Cell Lung Cancer Who Are Not Candidates for or Decline Surgery and Chemotherapy: A Practical Proposal by the International Geriatric Radiotherapy Group.

Nguyen NP ，Page BR ，Giap H ，Dahbi Z ，Vinh-Hung V ，Gorobets O ，Mohammadianpanah M ，Motta M ，Portaluri M ，Arenas M ，Bonet M ，Lara PC ，Kim L ，Dutheil F ，Natoli E ，Loganadane G ，Lehrman D ，Bose S ，Kaur S ，Blanco SC ，Chi A ... -  《Cancers》

Systemic therapy issues: Immunotherapy in nonmetastatic urothelial cancer.

Nadal R ，Apolo AB ，Girardi DM ，Hahn NM ，Bellmunt J ... -  《-》

Urothelial carcinoma in the era of immune checkpoint inhibitors.

Khalife N ，Chahine C ，Kordahi M ，Felefly T ，Kourie HR ，Saleh K ... -  《-》

The results of concurrent chemo-radiotherapy for recurrence after treatment with bacillus Calmette-Guérin for non-muscle-invasive bladder cancer: is immediate cystectomy always necessary?

Wo JY ，Shipley WU ，Dahl DM ，Coen JJ ，Heney NM ，Kaufman DS ，Zietman AL ... -  《-》