Transbronchial Cryoablation as Local Treatment for Central Airway Malignant Tumor.

Transbronchial cryoablation has been performed for peripheral but not central airway malignant tumor. We demonstrate transbronchial cryoablation in 2 patients with central airway lesions. Case 1 was an 86-year-old woman who developed intratracheal metastasis associated with postoperative recurrence of lung adenocarcinoma. The tumor was resected using a high-frequency electrosurgical snare and three transbronchial cryoablations. There was no tracheal recurrence in the 5 months after the third procedure. Case 2 was an 83-year-old man who developed intermediate bronchial metastasis associated with postoperative recurrence of lung squamous cell carcinoma. The tumor was resected using a high-frequency electrosurgical snare and one transbronchial cryoablation. There was no tumor recurrence in the bronchus intermedius for 12 months after treatment. In both cases, the only adverse event was minor bleeding. Transbronchial cryoablation deserves consideration as local treatment for central airway malignant tumors.

Hamakawa M ，Niwa T ，Fukuda Y ，Yokoyama T ，Ishida T ... -  《-》

Transbronchial cryoablation in peripheral lung parenchyma with a novel thin cryoprobe and initial clinical testing.

Gu C ，Yuan H ，Yang C ，Xie F ，Chen J ，Zhu L ，Jiang Y ，Sun J ... -  《-》

Initial experience with transbronchial cryoablation as a novel local treatment for malignant peripheral lung lesions.

Kohno M ，Hashimoto R ，Oiwa K ，Yashiro H ，Nakatsuka S ，Kawamura M ，Iwazaki M ... -  《BMJ Open Respiratory Research》

Transbronchial lung parenchyma cryoablation with a novel flexible cryoprobe in an in vivo porcine model.

The purpose of this study was to evaluate the feasibility and safety of transbronchial cryoablation with a novel flexible cryoprobe using nitrogen as the refrigerant in an in vivo porcine model of lung parenchyma. A novel flexible cryoprobe using nitrogen as the refrigerant was used for transbronchial cryoablation of lung parenchyma in six normal female pigs. The cryoprobe was delivered to the distal bronchus in the bilateral porcine lungs via the bronchoscopic working channel under virtual bronchoscopy guidance. The position was confirmed with real-time computed tomography (CT). The whole procedure included two freeze-thaw cycles (15 min and 2 min, respectively). CT images were obtained during cryoablation and at 24 h, one week, two weeks and four weeks after the treatment to assess the effectiveness and safety of the procedure. Ablation zone tissue samples were obtained at 24 h and four weeks after the cryoablation for further histopathological analysis. All ablation procedures (12/12; 100%) were performed successfully. No major complications occurred during the procedure or the observation period. The ablation zones were clearly depicted on CT with a maximal ablation zone volume at 24 h (21.88 ± 12.61 [SD] cm3) compared to 3.64 ± 2.06 (SD) cm3 and 10.73 ± 3.84 (SD) cm3 at the end of the 1st and 2nd freeze-thaw cycles, respectively (P < 0.001). Histopathological analysis revealed that a coagulative necrotic zone was formed along the target bronchus, with obvious vascular occlusion and hemorrhage 24 h after treatment. The lesions gradually formed fibrosis after four weeks. The novel flexible bronchoscopy-guided cryoablation is a feasible, safe and effective modality in an in vivo porcine model of peripheral normal lung parenchyma, suggesting potential capabilities for the treatment of peripheral lung cancer in humans.

Zheng X ，Yuan H ，Gu C ，Yang C ，Xie F ，Zhang X ，Xu B ，Sun J ... -  《Diagnostic and Interventional Imaging》

Bronchial pleomorphic adenoma coexisting with lung cancer.

Goto T ，Maeshima A ，Akanabe K ，Hamaguchi R ，Wakaki M ，Oyamada Y ，Kato R ... -  《-》