Indications for extensively hydrolyzed cow's milk protein in the neonatal period.

A large proportion of prescriptions for extensively hydrolyzed cow's milk protein (CMP) in newborns are not based on any scientific data justifying the indication. Many of these prescriptions are old habits or are based on incomplete data. The aim of this article is to analyze these practices and propose recommendations. The following points are covered: (a) indications for extensively hydrolyzed formula based on studies demonstrating their benefits in these situations-newborns with a proven allergy to CMP and occasional prescription of supplements to breastfeeding; (b) possible indications not based on a high level of evidence-re-initiation of feeding due to necrotizing enterocolitis, short bowel syndrome, re-initiation of feeding of newborns following intestinal surgery, and laparoschisis if neither the mother's own milk nor milk from a lactarium is available; (c) unjustified indications-newborns at risk of atopy, prematurity, severe neurological pathologies, newborns who are hemodynamically unstable and/or have congenital cardiopathy, neonatal hypoxic-ischemic encephalopathy treated with hypothermia, and newborns with esophageal atresia or diaphragmatic hernia. By following this classification, the prescriber will be guided to use the milk best suited to the pathology, bearing in mind that each situation must be adapted individually and the tolerance and effectiveness of the food reassessed from a nutritional and functional point of view.

Rigourd V ，Heneau A ，Virlouvet AL ，Basset A ，Herry E ，Jaquemet B ，Bellaiche M ，Lapillonne A ，Tounian P ... -  《-》

Consensus statement on diagnosis, treatment and follow-up of cow's milk protein allergy among infants and children in Turkey.

Kansu A ，Yüce A ，Dalgıç B ，Şekerel BE ，Çullu-Çokuğraş F ，Çokuğraş H ... -  《-》

The effect of a partially hydrolysed formula based on rice protein in the treatment of infants with cow's milk protein allergy.

Reche M ，Pascual C ，Fiandor A ，Polanco I ，Rivero-Urgell M ，Chifre R ，Johnston S ，Martín-Esteban M ... -  《-》

Formulas containing hydrolysed protein for prevention of allergy and food intolerance in infants.

Osborn DA ，Sinn J 《Cochrane Database of Systematic Reviews》

Prevention of Allergic Sensitization and Treatment of Cow's Milk Protein Allergy in Early Life: The Middle-East Step-Down Consensus.

Vandenplas Y ，Al-Hussaini B ，Al-Mannaei K ，Al-Sunaid A ，Helmi Ayesh W ，El-Degeir M ，El-Kabbany N ，Haddad J ，Hashmi A ，Kreishan F ，Tawfik E ... -  《Nutrients》