Fine-Needle Aspiration for Actionable Diagnosis of Mandibular Osteosarcoma Recurrence.

Mandibular osteosarcoma (MOS) is a rare malignant bone tumour known for its rapid and aggressive behaviour, particularly in cases of relapse. Early and accurate diagnosis is crucial for effective treatment. We report the case of a 48-year-old woman with recurrent MOS. Fine-needle aspiration cytology (FNAC) was utilized for diagnosis, facilitating prompt and appropriate treatment. The FNAC technique proved essential in confirming the diagnosis quickly, allowing for timely intervention. This case underscores the importance of FNAC in diagnosing MOS, especially in relapse situations where swift treatment is critical. FNAC can be a valuable tool in ensuring rapid and accurate diagnosis, leading to better patient outcomes.

Maffei E ，De Giulio F ，Rizzo PC ，Zeppa P ，Caputo A ... -  《-》

Mandibular osteosarcoma: a diagnostic pitfall on aspiration cytology of the salivary glands.

Daneshbod Y ，Khademi B 《-》

Role of fine needle aspiration cytology in the preoperative presumptive diagnosis of ameloblastoma.

Uçok O ，Doğan N ，Uçok C ，Günhan O ... -  《ACTA CYTOLOGICA》

Amelanotic melanoma recurrence diagnosed by fine-needle aspiration cytology: A case report.

Amelanotic melanoma is a variant of malignant melanoma. Amelanotic melanoma has similar morphology of a wide variety of epithelial and non-epithelial malignant tumours, variable cytomorphology of melanoma has been described on exfoliative and fine-needle aspiration cytology (FNAC). Aim of index study to describe FNAC of a rare case of recurrent amelanotic melanoma of right lateral knee swelling. Case: A 37-year-old male presented right lateral knee multi-nodular swelling last for 1 month with history of similar swelling 6 months back and operated. Histologically it was reported amelanotic malignant melanoma. FNAC revealed mordantly pleomorphic malignant cells predominantly plasmacytoid, plump shaped, prominent single to multiple nucleoli along with bi-nucleated and multi-nucleated tumour giant cells were also noted. Histology and immunohistochemistry (IHC) slides were reviewed and confirm the diagnosis. Concluded amelanotic melanoma has highly varied cytomorphology with multiple differential diagnosis and IHC markers are of great value for final diagnosis of it.

Khairwa A 《-》

Combined fine needle aspiration cytology and core needle biopsy in the same setting: A two-years' experience.

Fine needle aspiration cytology (FNAC) combined with rapid on-site evaluation (ROSE) and ancillary techniques is an accurate diagnostic tool for many pathologies. However, in some cases, it may not be sufficient for actionable diagnoses or molecular testing, especially for cases that require large immunohistochemical panels or cases in which histological features are mandatory for the diagnosis. Core needle biopsy (CNB), on the contrary, provides samples that are suitable for histological features and sufficient for all ancillary studies. However, CNB is often performed by radiologists or clinicians without the direct participation of cytopathologists, which can lead to missed or delayed diagnoses. This study reports on the experience of combining FNAC and CNB performed in one setting by cytopathologists. The aim was to evaluate the impact of CNB on FNAC and the diagnostic efficiency of the combined procedures. One hundred forty-two FNAC and CNB procedures performed in the same setting over a period of 2 years were analysed. The FNAC diagnoses were compared and integrated with the subsequent CNB diagnoses. The impact of CNB was categorized as follows: non-contributory, in cases of inadequate samples; confirmed, when the CNB and FNAC diagnoses were the same; improved, when the CNB diagnosis was consistent with the FNAC diagnosis and further specified the corresponding entity; allowed, when CNB produced a diagnosis that could not be reached by FNAC; changed, when the CNB changed the previous FNAC diagnosis. CNB confirmed the FNAC diagnosis in 40.1% of cases (n = 57/142). CNB improved the FNAC diagnosis in 47.2% of cases (n = 67/142). CNB allowed a diagnosis that could not be performed on FNAC in 2.1% of cases (n = 3/142). CNB changed a previous FNAC diagnosis in 2.1% of cases (n = 3/142). CNB was non-contributory in 8.4% of cases (n = 12/142). CNB produced a positive impact on the whole diagnostic procedure in 51.4% of total cases (n = 73/142). The combined FNAC and CNB resulted in actionable diagnoses in 91.5% of all cases (n = 130/142). A complete molecular assessment was successfully performed in 14.7% of cases (n = 21/142) utilizing either FNAC or CNB material. The combined use of FNAC and CNB in one setting improves the diagnostic accuracy of both procedures. This approach exploits the advantages of each procedure, enhancing the accuracy of the final diagnosis.

Ciliberti V ，Maffei E ，D'Ardia A ，Sabbatino F ，Serio B ，D'Antonio A ，Zeppa P ，Caputo A ... -  《-》