Growth Factors to Enhance Nerve Regeneration: Approaching Clinical Translation.

Following nerve injury, growth factors (GFs) are transiently upregulated in injured neurons, proliferating Schwann cells, and denervated muscle and skin. They act on these same cells and tissues to promote nerve regeneration and end-organ reinnervation. Consequently, much attention has been focused on developing GF-based therapeutics. A major barrier to clinical translation of GFs is their short half-life. To provide sustained GF treatment to the affected nerve, muscle, and skin in a safe and practical manner, engineered drug delivery systems are needed. This review highlights recent advancements in GF-based therapeutics and discusses the remaining hurdles for clinical translation.

Tuffaha S ，Lee EB 《-》

Growth factors-based therapeutic strategies and their underlying signaling mechanisms for peripheral nerve regeneration.

Li R ，Li DH ，Zhang HY ，Wang J ，Li XK ，Xiao J ... -  《-》

Growth Hormone Therapy Accelerates Axonal Regeneration, Promotes Motor Reinnervation, and Reduces Muscle Atrophy following Peripheral Nerve Injury.

Tuffaha SH ，Budihardjo JD ，Sarhane KA ，Khusheim M ，Song D ，Broyles JM ，Salvatori R ，Means KR Jr ，Higgins JP ，Shores JT ，Cooney DS ，Hoke A ，Lee WPA ，Brandacher G ... -  《-》

Therapeutic augmentation of the growth hormone axis to improve outcomes following peripheral nerve injury.

Tuffaha SH ，Singh P ，Budihardjo JD ，Means KR ，Higgins JP ，Shores JT ，Salvatori R ，Höke A ，Lee WP ，Brandacher G ... -  《-》

Growth factors: Bioactive macromolecular drugs for peripheral nerve injury treatment - Molecular mechanisms and delivery platforms.

Wan T ，Zhang FS ，Qin MY ，Jiang HR ，Zhang M ，Qu Y ，Wang YL ，Zhang PX ... -  《-》