Bloodstream Coinfections and Antimicrobial Resistance in Hospitalized COVID-19 Patients: A Single-center Retrospective Study.

Bloodstream infections in patients with COVID-19 are linked to higher mortality rates, whilst data on epidemiology and resistance patterns remains scarce to guide management and prevent antibiotic resistance. This research focuses on the prevalence, clinical features, causative microorganisms, and antimicrobial susceptibility of bacterial and fungal secondary bloodstream co-infections in hospitalized patients with COVID-19. In this retrospective study analysis of 230 patients with COVID-19 from Central Taiwan (June 2021 to June 2022), pathogens were identified via MALDI-TOF MS and Vitek 2 system with Clinical & Laboratory Standards Institute (CLSI) standards. In the cohort, 17.8% experienced bloodstream infections, resulting in a total of 45 isolates from the 41 bloodstream infection patients: predominantly gram-positive bacteria (Staphylococcus and Enterococcus) at 69%, gram-negative at 29% (Escherichia coli and Klebsiella pneumoniae), and fungi at 2%. Infected patients showed significantly elevated levels of white blood count (WBC), C-reactive protein (CRP) and procalcitonin (PCT). Of note, resistance to common antibiotics, such as fluoroquinolones, cephalosporins, and oxacillin was significant, especially in K. pneumoniae, Acinetobacter species, and S. aureus infections. Our study highlights the influence of bacterial infections in hospitalized patients with COVID-19. The bacterial infections were discovered to impact the clinical trajectory of COVID-19, potentially exacerbating or mitigating its symptoms, severity and fatality. These insights are pivotal to addressing clinical challenges in COVID-19 management and underscoring the need for tailored medical interventions. Understanding these co-infections is thus essential for optimizing patient care and improving overall outcomes in the post COVID-19 pandemic era.

Tsai YH ，Hou TC ，Liu PY ，Chen CJ ，Wang JM ... -  《-》

Bacterial co-infections in cancer patients with COVID-19: predictors and antimicrobial resistance trends.

Abdel-Hamid RM ，Bayoumi A ，Abdellateif MS ，Nooh HA ，Refaat L ，Kandeel EZ ，Hassan SS ... -  《Journal of Infection in Developing Countries》

Antimicrobial resistance trends in bloodstream infections at a large teaching hospital in China: a 20-year surveillance study (1998-2017).

Tian L ，Zhang Z ，Sun Z 《Antimicrobial Resistance and Infection Control》

Etiology and antimicrobial resistance of secondary bacterial infections in patients hospitalized with COVID-19 in Wuhan, China: a retrospective analysis.

Li J ，Wang J ，Yang Y ，Cai P ，Cao J ，Cai X ，Zhang Y ... -  《Antimicrobial Resistance and Infection Control》

Coinfections with Other Respiratory Pathogens among Patients with COVID-19.

Sreenath K ，Batra P ，Vinayaraj EV ，Bhatia R ，SaiKiran K ，Singh V ，Singh S ，Verma N ，Singh UB ，Mohan A ，Bhatnagar S ，Trikha A ，Guleria R ，Chaudhry R ... -  《Microbiology Spectrum》