Serum Uric Acid Combined with Homocysteine as a Predictive Biomarker of Lupus Nephritis.

Serum uric acid (UA) and homocysteine (Hcy) are potential biomarkers of systemic lupus erythematosus (SLE). In this study, the expressions of UA and Hcy in SLE patients and the predictive value of these two parameters for lupus nephritis (LN) were studied. A total of 476 SLE patients were recruited to this case-control study, of which 176 SLE patients diagnosed with LN and 300 without LN. Serum UA and Hcy levels were analyzed. Multivariate logistic regression analysis was used to evaluate the relationship between serum UA and Hcy and LN. The receiver operating characteristic (ROC) curves were used to predict the role of combination of serum UA and Hcy in LN. We found that serum UA and Hcy levels in SLE patients with LN were significantly higher than those in controls (p<0.05). Multivariate logistic regressions showed that serum UA (OR+=+1.003, 95+% CI: 1.001-1.006, p+=+0.003), apolipoprotein B (Apo B) (OR+=+21.361, 95+% CI: 2.312-195.373, p+=+0.007) and Hcy (OR+=+1.042, 95+% CI: 1.011-1.080, p+=+0.014) were independent markers of LN. Combined serum UA and Hcy revealed a better result (AUC+=+0.718, 95+% CI: 0.670-0.676, p<0.001) in prediction of LN compared to that of the serum UA (AUC+=+0.710) and Hcy (AUC+=+0.657) independently. In conclusion, serum UA and Hcy could be predictive biomarkers of LN, and joint detection of serum UA and Hcy might be useful in the clinical setting.

Zhang J ，Tian J ，Wang X ，Shen H ... -  《-》

Serum uric acid levels are associated with lupus nephritis in patients with normal renal function.

Calich AL ，Borba EF ，Ugolini-Lopes MR ，da Rocha LF ，Bonfá E ，Fuller R ... -  《-》

Association of serum uric acid with lupus nephritis in systemic lupus erythematosus.

Yang Z ，Liang Y ，Xi W ，Zhu Y ，Li C ，Zhong R ... -  《-》

Serum uric acid as a predictor for nephritis in Egyptian patients with systemic lupus erythematosus.

Hafez EA ，Hassan SAE ，Teama MAM ，Badr FM ... -  《-》

Diagnostic Values of Serum Levels of Homocysteine and Uric Acid for Predicting Vascular Mild Cognitive Impairment in Patients with Cerebral Small Vessel Disease.

Wang T ，Sun ZW ，Shao LQ ，Xu XB ，Liu Y ，Qin M ，Weng X ，Zhang YX ... -  《MEDICAL SCIENCE MONITOR》