Significant Disagreement Between Conventional Parameters and 3D Echocardiography-Derived Ejection Fraction in the Detection of Right Ventricular Systolic Dysfunction and Its Association With Outcomes.

Conventional echocardiographic parameters such as tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), and free-wall longitudinal strain (FWLS) offer limited insights into the complexity of right ventricular (RV) systolic function, while 3D echocardiography-derived RV ejection fraction (RVEF) enables a comprehensive assessment. We investigated the discordance between TAPSE, FAC, FWLS, and RVEF in RV systolic function grading and associated outcomes. We analyzed two- and three-dimensional echocardiography data from 2 centers including 750 patients followed up for all-cause mortality. Right ventricular dysfunction was defined as RVEF <45%, with guideline-recommended thresholds (TAPSE <17 mm, FAC <35%, FWLS >-20%) considered. Among patients with normal RVEF, significant proportions exhibited impaired TAPSE (21%), FAC (33%), or FWLS (8%). Conversely, numerous patients with reduced RVEF had normal TAPSE (46%), FAC (26%), or FWLS (41%). Using receiver-operating characteristic analysis, FWLS exhibited the highest area under the curve of discrimination for RV dysfunction (RVEF <45%) with 59% sensitivity and 92% specificity. Over a median 3.7-year follow-up, 15% of patients died. Univariable Cox regression identified TAPSE, FAC, FWLS, and RVEF as significant mortality predictors. Combining impaired conventional parameters showed that outcomes are the worst if at least 2 parameters are impaired and gradually better if only one or none of them are impaired (log-rank P < .005). Guideline-recommended cutoff values of conventional echocardiographic parameters of RV systolic function are only modestly associated with RVEF-based assessment. Impaired values of FWLS showed the closest association with the RVEF cutoff. Our results emphasize a multiparametric approach in the assessment of RV function, especially if 3D echocardiography is not available.

Tolvaj M ，Kovács A ，Radu N ，Cascella A ，Muraru D ，Lakatos B ，Fábián A ，Tokodi M ，Tomaselli M ，Gavazzoni M ，Perelli F ，Merkely B ，Badano LP ，Surkova E ... -  《-》

Serial changes of right ventricular function assessed by three-dimensional speckle-tracking echocardiography in clinically well adult heart transplantation patients.

The present study aimed to evaluate serial changes of right ventricular (RV) function in clinically well adult heart transplantation (HT) patients using three-dimensional speckle-tracking echocardiography (3D-STE). We included 58 adult HT patients, who were free from severe valvular insufficiency, severe coronary artery disease, acute rejection, or multiple organ transplantation, and 58 healthy controls. The healthy controls were matched by the distribution of age and sex with HT group. Conventional and three-dimensional (3D) echocardiography was performed in all HT patients at 1-, 3-, 6-, 9- and 12-months post-HT. And all the healthy controls underwent conventional and 3D echocardiography when recruited. Tricuspid annular plane systolic excursion (TAPSE), S' and RV fractional area change (RV FAC) were measured. Two-dimensional RV free wall longitudinal strain (2D-RV FWLS) was derived from two-dimensional speckle-tracking echocardiography (2D-STE). 3D RV free wall longitudinal strain (3D-RV FWLS) and RV ejection fraction (RVEF) were assessed by 3D-STE. TAPSE, S', RV FAC, 2D-RV FWLS, 3D-RV FWLS, and RVEF increased significantly from 1 to 6 months post-HT (P < 0.05). TAPSE, S', RV FAC and 2D-RV FWLS showed no significant changes from 6 to 12 months post-HT (P > 0.05), while 3D-RV FWLS and RVEF were still significantly increased: 3D-RV FWLS (17.9 ± 1.0% vs. 18.7 ± 1.4%, P < 0.001) and RVEF (45.9 ± 2.2% vs. 46.8 ± 2.0%, P = 0.025). By 12 months post-HT, TAPSE, S', RV FAC, 2D-RV FWLS, 3D-RV FWLS and RVEF were significantly lower than the healthy controls: TAPSE (15.1 ± 2.1 mm vs. 23.5 ± 3.0 mm, P < 0.001), s' (10.3 ± 1.9 cm/s vs. 12.9 ± 2.0 cm/s, P < 0.001), RV FAC (45.3 ± 1.8% vs. 49.2 ± 3.8%, P < 0.001), 2D-RV FWLS (19.9 ± 2.3% vs. 23.5 ± 3.8%, P < 0.001), 3D-RV FWLS (18.7 ± 1.4% vs. 22.4 ± 2.3%, P < 0.001) and RVEF (46.8 ± 2.0% vs. 49.9 ± 5.7%, P < 0.001). RV systolic function improved significantly over time in clinically well adult HT patients even up to 12 months post-HT. By 12 months post-HT, the patient's RV systolic function remained lower than the control. 3D-STE may be more suitable to assess RV systolic function in HT patients.

Li M ，Lv Q ，Zhang Y ，Sun W ，Wu C ，Zhang Y ，Zhu S ，Li H ，Dong N ，Li Y ，Zhang L ，Xie M ... -  《-》

Tricuspid annular plane systolic excursion is dependent on right ventricular volume in addition to function.

Tricuspid annular plane systolic excursion (TAPSE) is an effective parameter for assessing right ventricular (RV) function in echocardiographic studies. The preload dependency of TASPE has not been explored. We retrospectively reviewed 380 cardiac magnetic resonance (CMR) exams. RV ejection fraction (EF) and end-diastolic volume (EDV) were measured from short-axis cine images. TAPSE was measured as the difference of the perpendicular distance of the tricuspid annulus to the RV apex during diastole and systole. RV dysfunction was defined as RVEF <47%. The relationship of TAPSE, RVEF, and indexed RVEDV (RVEDVi) were evaluated. The TAPSE cut-off values derived from CMR were tested in a validation group (n = 46) with an echocardiographic exam performed within 1 month of the CMR. TAPSE had a good linear correlation with RVEF (r = .69, P < .001). In normal RVEF patients, TAPSE had a positive correlation with RVEDVi (r = .208, P = .014). Receiver operating characteristic analysis revealed a higher TAPSE cut-off value of 2.4 cm in the top normal to mildly dilated RV volume group for identifying RV dysfunction with lower predictive accuracy (sensitivity 80%, specificity 67%, area under the curve = 0.78, P < .001) as compared with 2.0 cm for the normal RV size or moderate to severely dilated RV groups. The higher TAPSE cutoff showed improved sensitivity (73% vs 43%) and Youden index (0.55 vs 0.43) in our validation cohort. Tricuspid annular plane systolic excursion not only correlates with RVEF, but also is dependent on RV volume. The cut-off value and predictive accuracy of TAPSE for detecting RV dysfunction vary with different RV volumes.

Zhao H ，Kang Y ，Pickle J ，Wang J ，Han Y ... -  《-》

Association of Right Ventricular Functional Parameters With Adverse Cardiopulmonary Outcomes: A Meta-analysis.

We aimed to confirm that three-dimensional echocardiography-derived right ventricular ejection fraction (RVEF) is better associated with adverse cardiopulmonary outcomes than the conventional echocardiographic parameters. We performed a meta-analysis of studies reporting the impact of unit change of RVEF, tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), and free-wall longitudinal strain (FWLS) on clinical outcomes (all-cause mortality and/or adverse cardiopulmonary outcomes). Hazard ratios (HRs) were rescaled by the within-study SDs to represent standardized changes. Within each study, we calculated the ratio of HRs related to a 1 SD reduction in RVEF versus TAPSE, or FAC, or FWLS, to quantify the association of RVEF with adverse outcomes relative to the other metrics. These ratios of HRs were pooled using random-effects models. Ten independent studies were identified as suitable, including data on 1,928 patients with various cardiopulmonary conditions. Overall, a 1 SD reduction in RVEF was robustly associated with adverse outcomes (HR = 2.64 [95% CI, 2.18-3.20], P < .001; heterogeneity: I2 = 65%, P = .002). In studies reporting HRs for RVEF and TAPSE, or RVEF and FAC, or RVEF and FWLS in the same cohort, head-to-head comparison revealed that RVEF showed significantly stronger association with adverse outcomes per SD reduction versus the other 3 parameters (vs TAPSE, HR = 1.54 [95% CI, 1.04-2.28], P = .031; vs FAC, HR = 1.45 [95% CI, 1.15-1.81], P = .001; vs FWLS, HR = 1.44 [95% CI, 1.07-1.95], P = .018). Reduction in three-dimensional echocardiography-derived RVEF shows stronger association with adverse clinical outcomes than conventional right ventricular functional indices; therefore, it might further refine the risk stratification of patients with cardiopulmonary diseases.

Sayour AA ，Tokodi M ，Celeng C ，Takx RAP ，Fábián A ，Lakatos BK ，Friebel R ，Surkova E ，Merkely B ，Kovács A ... -  《-》

Prognostic value of right ventricular three-dimensional speckle-tracking strain in adult heart transplantation patients.

We aimed to investigate the prognostic value of three-dimensional right ventricular free wall longitudinal strain (3D-RV FWLS) in adult heart transplantation (HTx) patients, taking three-dimensional left ventricular global longitudinal strain (3D-LV GLS) into account. We prospectively enrolled 155 adult HTx patients. Conventional right ventricular (RV) function parameters, two-dimensional (2D) RV FWLS, 3D-RV FWLS, RV ejection fraction (RVEF), and 3D-LV GLS were obtained in all patients. All patients were followed for the endpoint of death and major adverse cardiac events. After a median follow-up of 34 months, 20 (12.9%) patients had adverse events. Patients with adverse events had higher incidence of previous rejection, lower hemoglobin, and lower 2D-RV FWLS, 3D-RV FWLS, RVEF and 3D-LV GLS (P < 0.05). In multivariate Cox regression, Tricuspid annular plane systolic excursion (TAPSE), 2D-RV FWLS, 3D-RV FWLS, RVEF and 3D-LV GLS were independent predictors of adverse events. The Cox model using 3D-RV FWLS (C-index = 0.83, AIC = 147) or 3D-LV GLS (C-index = 0.80, AIC = 156) was observed to predict adverse events more accurately than that with TAPSE, 2D-RV FWLS, RVEF or traditional risk model. Moreover, when added in nested models including previous ACR history, hemoglobin levels, and 3D-LV GLS, the continuous NRI (0.396, 95% CI 0.013 ~ 0.647; P = 0.036) of 3D-RV FWLS was significant. 3D-RV FWLS is a stronger independent predictor of adverse outcomes, and provides additive predictive value over 2D-RV FWLS and conventional echocardiographic parameters in adult HTx patients, taking 3D-LV GLS into account.

Li M ，Lv Q ，Sun W ，Zhang Y ，Wu C ，Zhang Y ，Zhu S ，Li H ，Dong N ，Li Y ，Zhang L ，Xie M ... -  《-》