Preventive and Therapeutic Benefits of Natural Ingredients in Photo-Induced Epidermal Dysfunction.

The skin, particularly the epidermis, is subjected to various external stresses, including ultraviolet (UV) irradiation. UV irradiation, mainly UVB at wavelength of 280-315 nm, can alter several epidermal functions, including cutaneous inflammation, epidermal hyperproliferation, DNA damage, disruption of epidermal permeability barrier and reduction in stratum corneum hydration levels. Because of the negative impacts of UVB irradiation on epidermal functions, great efforts have been made to develop regimens for the protection of alterations in epidermal function induced by UV irradiation. While sunscreen can provide physical barrier to UV light, some natural ingredients can also effectively protect the skin from UVB irradiation-induced damages. Studies have demonstrated that either topical or oral administrations of some natural ingredients attenuate UVB irradiation-induced alterations in the epidermal function. The underlying mechanisms by which natural ingredients improve epidermal functions are attributable to antioxidation, stimulation of keratinocyte differentiation, increases in the content of epidermal natural moisturizers and inhibition of inflammation. Some natural ingredients exhibit protective and therapeutical benefits in photo-induced epidermal dysfunctions via divergent mechanisms.

Lei D ，Ye L ，Wen S ，Zhang J ，Zhang L ，Man MQ ... -  《-》

Benefits of topical natural ingredients in epidermal permeability barrier.

Lei D ，Liu D ，Zhang J ，Zhang L ，Man MQ ... -  《Frontiers in Physiology》

Relationship between expression of tight junction-related molecules and perturbed epidermal barrier function in UVB-irradiated hairless mice.

Yamamoto T ，Kurasawa M ，Hattori T ，Maeda T ，Nakano H ，Sasaki H ... -  《-》

Ultraviolet B-induced alterations of the skin barrier and epidermal calcium gradient.

Jiang SJ ，Chu AW ，Lu ZF ，Pan MH ，Che DF ，Zhou XJ ... -  《EXPERIMENTAL DERMATOLOGY》

Biophysical and morphological changes in the stratum corneum lipids induced by UVB irradiation.

Jiang SJ ，Chen JY ，Lu ZF ，Yao J ，Che DF ，Zhou XJ ... -  《JOURNAL OF DERMATOLOGICAL SCIENCE》