Neighbourhood Watch: Two-pore-2 channels talking to IP3 receptors.

The recent elegant study by Y. Yuan and colleagues examined functional relationships between the lysosomal two-pore channels 2 (TPC2) and IP3 receptors (IP3Rs) located in the endoplasmic reticulum [1]. The findings of this study suggest functional coupling of these channels and receptors. The study also describes interesting novel phenomena, which may indicate an additional coupling mechanism.

Criddle DN ，Tepikin AV 《-》

Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca(2+) signals between lysosomes and the endoplasmic reticulum.

Yuan Y ，Arige V ，Saito R ，Mu Q ，Brailoiu GC ，Pereira GJS ，Bolsover SR ，Keller M ，Bracher F ，Grimm C ，Brailoiu E ，Marchant JS ，Yule DI ，Patel S ... -  《Cell Reports》

Crosstalk between TPC2 and IP(3)R regulates Ca(2+) signals.

Calcium (Ca2+) plays a pivotal role in cellular signal transmission by triggering downstream signaling in response to an increase in the cytosolic Ca2+ concentration. Intracellular organelles serve as Ca2+ stores that induce differently shaped Ca2+ signals. We discuss a study by Yuan et al. that investigated the interplay between the lysosomal two-pore channel 2 (TPC2) and endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptors (IP3Rs).

Humer C ，Schindl R ，Sallinger M 《-》

Structural organization of signalling to and from IP3 receptors.

Taylor CW ，Tovey SC ，Rossi AM ，Lopez Sanjurjo CI ，Prole DL ，Rahman T ... -  《-》

Calcium signaling via two-pore channels: local or global, that is the question.

Zhu MX ，Ma J ，Parrington J ，Calcraft PJ ，Galione A ，Evans AM ... -  《-》