Changes in wider field swept-source OCT angiography vascular metrics with anti-vascular endothelial growth factor therapy in central retinal vein occlusion.

To investigate the impact of anti-VEGF therapy on vascular metrics in eyes with macular edema secondary to central retinal vein occlusion (CRVO) using wider field swept-source OCT angiography (WF SS-OCTA). We included 23 eyes with macular edema associated with non-ischemic CRVO from 22 patients treated with anti-VEGF therapy (median number of injections: 5 [2-9]). Changes in vessel density (VD), vessel skeletonized density (VSD), and foveal avascular zone (FAZ) parameters were measured using WF SS-OCTA. Visual acuity (VA) and central subfield thickness (CST) were also measured. Median CST decreased significantly from 369 µm (305-531) to 267 µm (243-300, p < 0.001). VD and VSD parameters in 12 × 12 mm images showed significant reductions. For instance, VSD in the whole retina decreased from a median of 13.37 (11.22-13.74) to 11.29 (9.36-12.97, p = 0.013). Additionally, a significant increase in FAZ circularity was found, suggesting improved microvascular integrity. Significant inverse correlations were found between the number of anti-VEGF injections and all VSD and VD parameters on the 12 × 12 mm images (p < 0.05). Notably, the reductions in VSD and VD on 12 × 12 mm angiograms in the deep capillary plexus (DCP) after each injection significantly correlated with increased logMAR VA (worse VA). Anti-VEGF therapy in CRVO patients not only mitigates macular edema but also alters the overall microvascular morphology and functionality as revealed by WF SS-OCTA.

Razavi P ，Baldwin G ，Garg I ，Velazquez LM ，Garcia M ，Gan J ，Choi H ，Zeng R ，Vingopoulos F ，Husain D ，Kim LA ，Patel NA ，Miller JB ... -  《-》

Optical Coherence Tomography Angiography Analysis of the Foveal Avascular Zone and Macular Vessel Density After Anti-VEGF Therapy in Eyes With Diabetic Macular Edema and Retinal Vein Occlusion.

Ghasemi Falavarjani K ，Iafe NA ，Hubschman JP ，Tsui I ，Sadda SR ，Sarraf D ... -  《-》

Widefield, Swept-Source Optical Coherence Tomography Angiography Metrics as Predictors of Anti-VEGF Treatment in Retinal Vein Occlusions.

Finn MJ ，Baldwin G ，Lains I ，Garg I ，Wescott H ，Vingopoulos F ，Zeng R ，Choi H ，Tracy J ，Razavi P ，Sayeh D ，Patel NA ，Wu DM ，Vavvas DG ，Miller JB ... -  《-》

Changes in Retinal Microvasculature and Visual Acuity After Antivascular Endothelial Growth Factor Therapy in Retinal Vein Occlusion.

Winegarner A ，Wakabayashi T ，Fukushima Y ，Sato T ，Hara-Ueno C ，Busch C ，Nishiyama I ，Shiraki N ，Sayanagi K ，Nishida K ，Sakaguchi H ，Nishida K ... -  《-》

Baseline Factors Associated With 6-Month Visual Acuity and Retinal Thickness Outcomes in Patients With Macular Edema Secondary to Central Retinal Vein Occlusion or Hemiretinal Vein Occlusion: SCORE2 Study Report 4.

Scott IU ，VanVeldhuisen PC ，Ip MS ，Blodi BA ，Oden NL ，King J ，Antoszyk AN ，Peters MA ，Tolentino M ，SCORE2 Investigator Group ... -  《-》