Ferroptosis: A potential therapeutic target in autoimmune disease (Review).

Ferroptosis is a distinct type of regulated cell death characterized by iron overload and lipid peroxidation. Ferroptosis is regulated by numerous factors and controlled by several mechanisms. This cell death type has a relationship with the immune system, which may be regulated by damage-associated molecular patterns. Ferroptosis participates in the progression of autoimmune diseases, including autoimmune hepatitis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel disease, multiple sclerosis, Parkinson's Disease, psoriasis and insulin-dependent diabetes mellitus. The present review summarizes the role of ferroptosis in autoimmune disorders and discusses ferroptosis as a potential therapeutic target for autoimmune disease.

Shen L ，Wang X ，Zhai C ，Chen Y ... -  《-》

Targeting ferroptosis in autoimmune diseases: Mechanisms and therapeutic prospects.

Zheng Y ，Yan F ，He S ，Luo L ... -  《-》

Programmed cell death in autoimmune diseases: ferroptosis.

Sun J ，Huang L ，Wang J ，Hu Y ，Wang W ，Zhu H ... -  《-》

Ferroptosis as an emerging target in rheumatoid arthritis.

Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology. Due to the rise in the incidence rate of RA and the limitations of existing therapies, the search for new treatment strategies for RA has become a global focus. Ferroptosis is a novel programmed cell death characterized by iron-dependent lipid peroxidation, with distinct differences from apoptosis, autophagy, and necrosis. Under the conditions of iron accumulation and the glutathione peroxidase 4 (GPX4) activity loss, the lethal accumulation of lipid peroxide is the direct cause of ferroptosis. Ferroptosis mediates inflammation, oxidative stress, and lipid oxidative damage processes, and also participates in the occurrence and pathological progression of inflammatory joint diseases including RA. This review provides insight into the role and mechanism of ferroptosis in RA and discusses the potential and challenges of ferroptosis as a new therapeutic strategy for RA, with an effort to provide new targets for RA prevention and treatment.

Zhao H ，Tang C ，Wang M ，Zhao H ，Zhu Y ... -  《Frontiers in Immunology》

Advances in the study of ferroptosis and its relationship to autoimmune diseases.

Dong W ，Xu H ，Wei W ，Ning R ，Chang Y ... -  《-》