Phakellisins A-E, cyclopeptides from a marine sponge Phakellia sp. guided by LC-MS.

A chemical investigation of the marine sponge Phakellia sp. from the South China Sea yielded five new cyclopeptides, phakellisins A-E (1-5). Structures of these compounds were determined by comprehensive analysis of 1D/2D NMR, HRESIMS/MS spectroscopic data and the advanced Marfey's method. All compounds were evaluated for their cytotoxic activity. Compound 1 showed a strong inhibitory activity against WSU-DLCL-2 cells with an IC50 value of 5.25 ± 0.2 μM by induction of G0/G1 cell cycle arrest and apoptosis.

Kong C ，Wu Y ，Zhao HM ，Zhang SS ，Wu ZM ，Li XB ，Liu KC ，Lin HW ，Wang SP ... -  《-》

Cyclopsammocinamides A and B, Enantiomeric Cyclic Peptides of Cyclocinamide A, from the Marine Sponge Psammocinia sp.

El-Desoky AHH ，Hitora Y ，Onodera K ，Ise Y ，Losung F ，Mangindaan REP ，Tsukamoto S ... -  《-》

Proline-containing cyclopeptides from the marine sponge Phakellia fusca.

Zhang HJ ，Yi YH ，Yang GJ ，Hu MY ，Cao GD ，Yang F ，Lin HW ... -  《-》

Reniochalistatins A-E, cyclic peptides from the marine sponge Reniochalina stalagmitis.

Zhan KX ，Jiao WH ，Yang F ，Li J ，Wang SP ，Li YS ，Han BN ，Lin HW ... -  《-》

Antineoplastic agents, 325. Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11 from Phakellia sp.

Pettit GR ，Tan R ，Ichihara Y ，Williams MD ，Doubek DL ，Tackett LP ，Schmidt JM ，Cerny RL ，Boyd MR ，Hooper JN ... -  《JOURNAL OF NATURAL PRODUCTS》