Heat shock proteins and cancer: The FoxM1 connection.

Heat shock proteins (Hsp) and FoxM1 have significant roles in carcinogenesis. According to their relative molecular weight, Hsps are divided into Hsp110, Hsp90, Hsp70, Hsp60, Hsp40, and small Hsps. Hsp70 can play essential functions in cancer initiation and is overexpressed in several human cancers. Hsp70, in combination with cochaperones HIP and HOP, refolds partially denatured proteins and acts as a cochaperone for Hsp90. Also, Hsp70, in combination with BAG3, regulates the FoxM1 signaling pathway. FoxM1 protein is a transcription factor of the Forkhead family that is overexpressed in most human cancers and is involved in many cancers' development features, including proliferation, migration, invasion, angiogenesis, metastasis, and resistance to apoptosis. This review discusses the Hsp70, Hsp90, and FoxM1 structure and function, the known Hsp70 cochaperones, and Hsp70, Hsp90, and FoxM1 inhibitors.

Alimardan Z ，Abbasi M ，Hasanzadeh F ，Aghaei M ，Khodarahmi G ，Kashfi K ... -  《-》

Interaction of the Hsp90 cochaperone cyclophilin 40 with Hsc70.

Carrello A ，Allan RK ，Morgan SL ，Owen BA ，Mok D ，Ward BK ，Minchin RF ，Toft DO ，Ratajczak T ... -  《-》

Expression of heat shock proteins in medulloblastoma.

Alexiou GA ，Vartholomatos G ，Stefanaki K ，Patereli A ，Dova L ，Karamoutsios A ，Lallas G ，Sfakianos G ，Moschovi M ，Prodromou N ... -  《-》

The role of heat shock proteins in metastatic colorectal cancer: A review.

Heat shock proteins (HSPs) are a large molecular chaperone family classified by their molecular weights, including HSP27, HSP40, HSP60, HSP70, HSP90, and HSP110. HSPs are likely to have antiapoptotic properties and participate actively in various processes such as tumor cell proliferation, invasion, metastases, and death. In this review, we discuss comprehensively the functions of HSPs associated with the progression of colorectal cancer (CRC) and metastasis and resistance to cancer therapy. Taken together, HSPs have numerous clinical applications as biomarkers for cancer diagnosis and prognosis and potential therapeutic targets for CRC and its related metastases.

Javid H ，Hashemian P ，Yazdani S ，Sharbaf Mashhad A ，Karimi-Shahri M ... -  《-》

[Cooperation between heat shock proteins in organizing of proteins spatial structure].

Wyżewski Z ，Gregorczyk KP ，Szulc-Dąbrowska L ，Struzik J ，Szczepanowska J ，Niemiałtowski M ... -  《-》