STereotactic Arrhythmia Radioablation (STAR): the Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary consortium (STOPSTORM.eu) and review of current patterns of STAR practice in Europe.

The EU Horizon 2020 Framework-funded Standardized Treatment and Outcome Platform for Stereotactic Therapy Of Re-entrant tachycardia by a Multidisciplinary (STOPSTORM) consortium has been established as a large research network for investigating STereotactic Arrhythmia Radioablation (STAR) for ventricular tachycardia (VT). The aim is to provide a pooled treatment database to evaluate patterns of practice and outcomes of STAR and finally to harmonize STAR within Europe. The consortium comprises 31 clinical and research institutions. The project is divided into nine work packages (WPs): (i) observational cohort; (ii) standardization and harmonization of target delineation; (iii) harmonized prospective cohort; (iv) quality assurance (QA); (v) analysis and evaluation; (vi, ix) ethics and regulations; and (vii, viii) project coordination and dissemination. To provide a review of current clinical STAR practice in Europe, a comprehensive questionnaire was performed at project start. The STOPSTORM Institutions' experience in VT catheter ablation (83% ≥ 20 ann.) and stereotactic body radiotherapy (59% > 200 ann.) was adequate, and 84 STAR treatments were performed until project launch, while 8/22 centres already recruited VT patients in national clinical trials. The majority currently base their target definition on mapping during VT (96%) and/or pace mapping (75%), reduced voltage areas (63%), or late ventricular potentials (75%) during sinus rhythm. The majority currently apply a single-fraction dose of 25 Gy while planning techniques and dose prescription methods vary greatly. The current clinical STAR practice in the STOPSTORM consortium highlights potential areas of optimization and harmonization for substrate mapping, target delineation, motion management, dosimetry, and QA, which will be addressed in the various WPs.

Grehn M ，Mandija S ，Miszczyk M ，Krug D ，Tomasik B ，Stickney KE ，Alcantara P ，Alongi F ，Anselmino M ，Aranda RS ，Balgobind BV ，Boda-Heggemann J ，Boldt LH ，Bottoni N ，Cvek J ，Elicin O ，De Ferrari GM ，Hassink RJ ，Hazelaar C ，Hindricks G ，Hurkmans C ，Iotti C ，Jadczyk T ，Jiravsky O ，Jumeau R ，Kristiansen SB ，Levis M ，López MA ，Martí-Almor J ，Mehrhof F ，Møller DS ，Molon G ，Ouss A ，Peichl P ，Plasek J ，Postema PG ，Quesada A ，Reichlin T ，Rordorf R ，Rudic B ，Saguner AM ，Ter Bekke RMA ，Torrecilla JL ，Troost EGC ，Vitolo V ，Andratschke N ，Zeppenfeld K ，Blamek S ，Fast M ，de Panfilis L ，Blanck O ，Pruvot E ，Verhoeff JJC ... -  《-》

Refining critical structure contouring in STereotactic Arrhythmia Radioablation (STAR): Benchmark results and consensus guidelines from the STOPSTORM.eu consortium.

Balgobind BV ，Visser J ，Grehn M ，Marquard Knap M ，de Ruysscher D ，Levis M ，Alcantara P ，Boda-Heggemann J ，Both M ，Cozzi S ，Cvek J ，Dieleman EMT ，Elicin O ，Giaj-Levra N ，Jumeau R ，Krug D ，Algara López M ，Mayinger M ，Mehrhof F ，Miszczyk M ，Pérez-Calatayud MJ ，van der Pol LHG ，van der Toorn PP ，Vitolo V ，Postema PG ，Pruvot E ，Verhoeff JC ，Blanck O ... -  《-》

Implementing stereotactic arrhythmia radioablation with STOPSTORM.eu consortium support: intermediate results of a prospective Israeli single-institutional trial.

Borzov E ，Efraim R ，Suleiman M ，Bar-Deroma R ，Billan S ，Xie J ，Hohmann S ，Blanck O ，Charas T ... -  《-》

Refining Treatment Planning in STereotactic Arrhythmia Radioablation: Benchmark Results and Consensus Statement From the STOPSTORM.eu Consortium.

Trojani V ，Grehn M ，Botti A ，Balgobind B ，Savini A ，Boda-Heggemann J ，Miszczyk M ，Elicin O ，Krug D ，Andratschke N ，Schmidhalter D ，van Elmpt W ，Bogowicz M ，de Areba Iglesias J ，Dolla L ，Ehrbar S ，Fernandez-Velilla E ，Fleckenstein J ，Granero D ，Henzen D ，Hurkmans C ，Kluge A ，Knybel L ，Loopeker S ，Mirandola A ，Richetto V ，Sicignano G ，Vallet V ，van Asselen B ，Worm E ，Pruvot E ，Verhoeff J JC ，Fast M F ，Iori M ，Blanck O ... -  《-》

Patient vulnerability in stereotactic arrhythmia radioablation (STAR): a preliminary ethical appraisal from the STOPSTORM.eu consortium.

This preliminary ethical appraisal from the STOPSTORM.eu consortium is meant to raise critical points that clinicians administering stereotactic arrhythmia radioablation should consider to meet the highest standards in medical ethics and thus promote quality of life of patients recruited for radiotherapy treatments at a stage in which they experience a significant degree of vulnerability.

Botrugno C ，Crico C ，Iori M ，Blanck O ，Blamek S ，Postema PG ，Quesada A ，Pruvot E ，Verhoeff JJC ，De Panfilis L ... -  《-》