Molecular insight into the study of adult T-cell leukemia/lymphoma (ATLL): Ten-year studies on HTLV-1 associated diseases in an endemic region.

The outcome of successful infection, including human T-cell leukemia virus type 1 (HTLV-1), is determined by the interactions between the host and the infectious agent. Ten years of work on HTLV-1-associated diseases in an endemic region of Iran have been critically compared in the present study. The outstanding findings of RNA-seq, system biology analysis, and gene expression measurements on adult T-cell leukemia/lymphoma (ATLL) and enzootic bovine leukosis(EBL) in our lab encouraged us to investigate the significant role of oncogenes in the ATLL malignancy. Most studies assessed such interactions by the proviral load (PVL), Tax, and HBZ regulatory proteins in HTLV-1 and the host's immunological and cell cycle factors. The current study is a comprehensive comparing view of our previously published and unpublished results investigating the HTLV-1-host interactions leading to the transformation of the infected cell. The main focus has been on the essential proteins implicated in the virus dissemination, cell survival, and proliferation of infected cells toward leukemia development and progression. Similar to its homolog BLV-AS-1-2 in EBL, the HTLV-1-HBZ is a pivotal factor in the maintenance and progression of the ATLL. In addition, the inappropriate activities of the PI3K/Akt pathway, BRCAs, and RAD51 in the DNA repair system, which are orchestrating many other immortalization pathways, might be the central factors in the manifestation of ATLL. HTLV-1-HBZ and the host PI3K/Akt pathway, BCAs, and RAD51 could be suggested as influential targets for the prognosis and proper therapy of ATLL.

Ashrafi F ，Rahimzada M ，Parandi M ，Mirhosseini A ，Mashkani B ，Ahmadi Ghezeldasht S ，Soltani A ，Rafatpanah H ，Mosavat A ，Abdolrahim Rezaee S ... -  《-》

Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL).

Ahmadi Ghezeldasht S ，Blackbourn DJ ，Mosavat A ，Rezaee SA ... -  《-》

HTLV-1-host interactions on the development of adult T cell leukemia/lymphoma: virus and host gene expressions.

Tarokhian H ，Rahimi H ，Mosavat A ，Shirdel A ，Rafatpanah H ，Akbarin MM ，Bari A ，Ramezani S ，Rezaee SA ... -  《BMC CANCER》

Assessment of HTLV-1 proviral load, LAT, BIM, c-FOS and RAD51 gene expression in adult T cell leukemia/lymphoma.

Ramezani S ，Shirdel A ，Rafatpanah H ，Akbarin MM ，Tarokhian H ，Rahimi H ，Bari A ，Jahantigh HR ，Rezaee SA ... -  《-》

Tax protein-induced expression of antiapoptotic Bfl-1 protein contributes to survival of human T-cell leukemia virus type 1 (HTLV-1)-infected T-cells.

Macaire H ，Riquet A ，Moncollin V ，Biémont-Trescol MC ，Duc Dodon M ，Hermine O ，Debaud AL ，Mahieux R ，Mesnard JM ，Pierre M ，Gazzolo L ，Bonnefoy N ，Valentin H ... -  《-》