Hepatic Steatosis and High-Normal Fasting Glucose as Risk Factors for Incident Prediabetes.

The role of hepatic steatosis (HS) in the initial stages of developing type 2 diabetes remains unclear. We aimed to clarify the impact of HS indexed by Fatty Liver Index (FLI) and high-normal fasting plasma glucose (FPG) as risk factors for incident prediabetes in a nonobese cohort. Data from 1125 participants with ADA-defined normal glucose metabolism (median age 52 years; BMI 23.1 kg/m2) were used for retrospective analysis. In the entire population, correlation between normal FPG and FLI was evaluated by multiple regression adjusted for age and sex. Follow-up data from 599 participants in whom 75-g OGTT was repeated 3.7 years later showed that 169 developed prediabetes. This was analyzed by the multivariate Cox proportional hazards model. In the entire population, FLI was positively correlated with FPG (P < 0.01): mean FLI increased from 15.8 at FPG 4.2 mmol/L to 31.6 at FPG 5.5 mmol/L. Analysis of the 599 participants (2061 person-years) by Cox model, adjusted for sex, age, family history of diabetes, ISIMATSUDA, and Stumvoll-1, clarified an increased risk of prediabetes with high-normal FPG and FLI. Risk was increased 2.2 times with FLI ≥ 16.5 vs FLI < 16.5, P < 0.001, and increased 2.1 times in participants with FPG ≥ 5.3 mmol/L, P < 0.001. Cutoff values (unadjusted) were obtained by ROC at the point of the largest Youden's index using the entire range of the variables. Even among nonobese individuals, HS indexed by FLI and a high-normal FPG (≥ 5.3 mmol/L) are risk factors for prediabetes, independently from insulin.

Aizawa T ，Nakasone Y ，Murai N ，Oka R ，Nagasaka S ，Yamashita K ，Sakuma T ，Kiyosawa K ... -  《Journal of the Endocrine Society》

Fatty liver index is a strong predictor of changes in glycemic status in people with prediabetes: The IT-DIAB study.

Wargny M ，Smati S ，Pichelin M ，Bigot-Corbel E ，Authier C ，Dierry V ，Zaïr Y ，Jacquin V ，Hadjadj S ，Boursier J ，Cariou B ... -  《PLoS One》

Utility of Fatty Liver Index to predict reversion to normoglycemia in people with prediabetes.

Busquets-Cortés C ，Bennasar-Veny M ，López-González ÁA ，Fresneda S ，Abbate M ，Yáñez AM ... -  《PLoS One》

Report of the Committee on the classification and diagnostic criteria of diabetes mellitus.

Kuzuya T ，Nakagawa S ，Satoh J ，Kanazawa Y ，Iwamoto Y ，Kobayashi M ，Nanjo K ，Sasaki A ，Seino Y ，Ito C ，Shima K ，Nonaka K ，Kadowaki T ，Committee of the Japan Diabetes Society on the diagnostic criteria of diabetes mellitus ... -  《DIABETES RESEARCH AND CLINICAL PRACTICE》

Fatty liver index is a predictor of incident diabetes in patients with prediabetes: The PREDAPS study.

Franch-Nadal J ，Caballeria L ，Mata-Cases M ，Mauricio D ，Giraldez-García C ，Mancera J ，Goday A ，Mundet-Tudurí X ，Regidor E ，PREDAPS Study Group ... -  《PLoS One》