Chiral Nanozymes for Enantioselective Biological Catalysis.

As a neat combination of the characteristics of enzymatic activity and nanomaterials, nanozymes have attracted much attention. Although tremendous effort has been devoted to developing nanozymes with high catalytic activity, substrate selectivity is often overlooked in the construction of nanozymes. With their subtly evolving structures, natural enzymes generally possess high selectivity for chiral substrates which play important roles in biosynthesis and biomedical applications. However, the rational construction of nanozymes with high enantioselectivity remains a significant challenge. In this Minireview, we provide an overview of recent advances in strategies for the synthesis of chiral nanozymes and their enantioselective biological catalysis. We further focus on current challenges, potential solutions, and future developing trends of chiral nanozyme-based enantioselective biological catalysis. There is plenty of room to explore. This Minireview will provide new insights into the development of chiral nanozymes and their applications.

Dong K ，Xu C ，Ren J ，Qu X ... -  《-》

Advances in chiral nanozymes: a review.

Zhang R ，Zhou Y ，Yan X ，Fan K ... -  《-》

Applications of Nanozymes in Chiral-Molecule Recognition through Electrochemical and Ultraviolet-Visible Analysis.

Dai JJ ，Chen GY ，Xu L ，Zhu H ，Yang FQ ... -  《-》

Supramolecular Polyaniline-Metal Ion as Chiral Nanozymes for Enantioselective Catalysis.

Understanding origin of asymmetric information encoded on chiral nanozymes is important in mediating enantioselective catalysis. Herein, the supramolecular chiral nanozymes constructed from P/M-polyaniline (P/M-PANI) nanotwists and metal ions (M2+ , M = Cu, Ni, Co, and Zn) are designed through thioglycolic acid (TA) without chiral molecules to show the regulated catalytic efficiency and enantioselectivity. With combination of chiral environment from supramolecular scaffolds and catalytic center from metal ions, the P-PANI-TA-M2+ as nanozymes show preference to 3,4-dihydroxy-S-phenylalanine (S-DOPA) oxidation while the M-PANI-TA-M2+ show better selectivity to R-DOPA oxidation. Among them, though the Cu2+ doped supramolecular nanotwists show the highest catalytic efficiency, the Co2+ doped ones with moderate catalytic efficiency can exhibit the best enantioselectivity with select factor as high as 2.07. The molecular dynamic (MD) simulation clarifies the mechanism of enantioselective catalysis caused by the differential kinetics with S/R-DOPA enantiomers adsorbed on chiral PANI surface and free in solution. This work systematically studies the synergistic effect between the chiral supramolecular nanostructures assembled by achiral species and metal ions as peroxidase-like catalytic centers to regulate the enantioselectivity, providing deep understanding of the origin of asymmetric catalysis and serving as strong foundation to guide the design of nanozymes with high enantioselectivity.

Yuan G ，Wang C ，Xi Z ，Li S ，Sun X ，Hang P ，Liu X ，Han J ，Guo R ... -  《-》

Enzyme Mimic Nanomaterials and Their Biomedical Applications.

Nanomaterials with enzyme-mimicking behavior (nanozymes) have attracted a lot of research interest recently. In comparison to natural enzymes, nanozymes hold many advantages, such as good stability, ease of production and surface functionalization. As the catalytic mechanism of nanozymes is gradually revealed, the application fields of nanozymes are also broadly explored. Beyond traditional colorimetric detection assays, nanozymes have been found to hold great potential in a variety of biomedical fields, such as tumor theranostics, antibacterial, antioxidation and bioorthogonal reactions. In this review, we summarize nanozymes consisting of different nanomaterials. In addition, we focus on the catalytic performance of nanozymes in biomedical applications. The prospects and challenges in the practical use of nanozymes are discussed at the end of this Minireview.

Shang Y ，Liu F ，Wang Y ，Li N ，Ding B ... -  《-》