New iridal-type triterpenoid analogues with 6/5/6-fused carbon skeleton from the rhizomes of Belamcanda chinensis.

Five new iridal-type triterpenoid derivatives with 6/5/6 tricyclic ring skeleton (1-5) were obtained from the rhizomes of Belamcanda chinensis. Their structures were determined on the basis of detailed spectroscopic data and ECD calculation. Compounds 1-5 possessed the same 6/5/6-fused carbon skeleton as Belamchinenin A, which further enriched this kind of iridals. In vitro bioassay, compounds 2 and 3 exhibited 51.95 and 54.52% inhibitory activities, respectively, against Fe2+/cysteine-induced liver microsomal lipid peroxidation at a concentration of 10 μM. A putative biogenetic pathway for compounds 1-5 was proposed.

Li J ，Ni G ，Liu Y ，Wang R ，Yu D ... -  《-》

Iridal-Type Triterpenoids with a Cyclopentane Unit from the Rhizomes of Belamcanda chinensis.

Li J ，Ni G ，Liu Y ，Mai Z ，Wang R ，Yu D ... -  《-》

New iridal-type triterpenoid derivatives with cytotoxic activities from Belamcanda chinensis.

Eight new iridal-type triterpenoid derivatives, including two noriridals with ether bridge (1-2); two iridals lactone (3-4), four monocyclic iridals (5-8), together with five known iridals (9-14) were identified from the rhizome of Belamcanda chinensis. Their structures were elucidated on the basis of comprehensive spectroscopic methods and electronic circular dichroism (ECD) calculations. Bioassay results showed that belamcanoxide B (1) exhibited moderated cytotoxic activities against HCT-116 and MCF-7 cell lines with IC50 values of 5.58 and 3.35 μM.

Li J ，Ni G ，Li L ，Liu Y ，Mai Z ，Wang R ，Yu D ... -  《-》

Belamchinenin A, an unprecedented tricyclic-fused triterpenoid with cytotoxicity from Belamcanda chinensis.

Ni G ，Li JY ，Yu DQ 《-》

A new dimeric iridal triterpenoid from Belamcanda chinensis with significant molluscicide activity.

Song ZJ ，Xu XM ，Deng WL ，Peng SL ，Ding LS ，Xu HH ... -  《-》