The role of non-coding RNAs in ferroptosis regulation.

Ferroptosis is a newly recognized form of cell death that is distinct from apoptosis, necrosis, autophagy in morphology, biochemistry, and heredity. The basic process of ferroptosis involves disordered permeability of plasma membrane, which is caused by abnormal accumulation of lipids and reactive oxygen species (ROS). The regulatory mechanism of ferroptosis is important due to its involvement in tumor progression, neurotoxicity, neurodegenerative diseases, acute renal failure, and ischemia-reperfusion injury. Recent studies have shown that in ferroptosis metabolism, non-coding RNAs (ncRNAs) can interfere with multiple signaling pathways at both the pre-transcriptional and post-transcriptional levels. Despite great progress, current research on the mechanism of ncRNAs and ferroptosis remains insufficient. This review provides an overview of the main mechanisms and targets of ferroptosis and focuses on the mechanisms of non-coding RNA regulation. Analyzing the deficiencies in current research may provide ideas for future studies to investigate.

Qi R ，Bai Y ，Wei Y ，Liu N ，Shi B ... -  《-》

Noncoding RNAs regulating ferroptosis in cardiovascular diseases: novel roles and therapeutic strategies.

Wu C ，Bao S ，Sun H ，Chen X ，Yang L ，Li R ，Peng Y ... -  《-》

Ferroptosis in Cancer Progression: Role of Noncoding RNAs.

Ferroptosis is a novel form of programmed cell death, and it is characterized by iron-dependent oxidative damage, lipid peroxidation and reactive oxygen species accumulation. Notable studies have revealed that ferroptosis plays vital roles in tumor occurrence and that abundant ferroptosis in cells can inhibit tumor progression. Recently, some noncoding RNAs (ncRNAs), particularly microRNAs, long noncoding RNAs, and circular RNAs, have been shown to be involved in biological processes of ferroptosis, thus affecting cancer growth. However, the definite regulatory mechanism of this phenomenon is still unclear. To clarify this issue, increasing studies have focused on the regulatory roles of ncRNAs in the initiation and development of ferroptosis and the role of ferroptosis in progression of various cancers, such as lung, liver, and breast cancers. In this review, we systematically summarized the relationship between ferroptosis-associated ncRNAs and cancer progression. Moreover, additional evidence is needed to identify the role of ferroptosis-related ncRNAs in cancer progression. This review will help us to understand the roles of ncRNAs in ferroptosis and cancer progression and may provide new ideas for exploring novel diagnostic and therapeutic biomarkers for cancer in the future.

Zuo YB ，Zhang YF ，Zhang R ，Tian JW ，Lv XB ，Li R ，Li SP ，Cheng MD ，Shan J ，Zhao Z ，Xin H ... -  《International Journal of Biological Sciences》

Crosstalk between noncoding RNAs and ferroptosis: new dawn for overcoming cancer progression.

Zhang X ，Wang L ，Li H ，Zhang L ，Zheng X ，Cheng W ... -  《Cell Death & Disease》

Ferroptosis: mechanisms and links with diseases.

Yan HF ，Zou T ，Tuo QZ ，Xu S ，Li H ，Belaidi AA ，Lei P ... -  《-》