Squamous Cell Carcinoma Arising from Perianal Buschke-Lowenstein Tumor (Giant Condyloma Acuminatum): Comprehensive Literature Review.

This study aims to provide an overview of the literature on carcinoma arising from giant perianal condyloma acuminatum. We present a new case of squamous cell carcinoma arising from giant perianal condyloma acuminatum. We also conducted a systematic search of the medical literature using PubMed, Medline, Google, and Google Scholar related to carcinoma arising from giant perianal condyloma acuminatum. The following search terms were used in various combinations: condyloma acuminatum, giant condyloma acuminatum, Buschke-Lowenstein tumor, squamous cell carcinoma, and verrucous carcinoma. The search included articles published before in the English language November 2020. A total of 55 article concerning 97 patients with carcinoma (squamous cell carcinoma, verrucous carcinoma, basaloid cell carcinoma, carcinoma insitu) arising from giant perianal condyloma acuminatum meeting the aforementioned criteria were included. The patients were aged from 24 to 82 years (median: 49.6, IQR: 21); 20 were female (median age: 52.5, IQR: 20.5), and 75 were male (median age: 53, IQR: 17.5). The gender data of the remaining two patients could not be obtained. The histopathological features of tumors arising from giant condyloma acuminatum are as follows: squamous cell carcinoma (n = 56), squamous cell carcinoma in situ (n = 16), verrucous carcinoma (n = 19) and basaloid cell carcinoma (n = 1), squamous cell carcinoma + verrucous carcinoma (n = 1), squamous cell carcinoma + squamous cell carcinoma in situ (n = 1), squamous cell carcinoma + basaloid cell carcinoma (n = 1) and malignant behavior (n = 2). Giant condyloma acuminatum is a rare variant of anogenital warts. It is known that this tumor, which is mostly thought to be benign, has a high potential for local recurrence and transformation into invasive cancer. Therefore, it is vital that the tumor is resected with clean surgical margins, even if it looks benign, and that aggressive treatment options are not avoided when necessary.

Ates M ，Akbulut S ，Tuncer A ，Sahin E ，Karabulut E ，Sarici KB ... -  《-》

Condylomata acuminata, giant condyloma acuminatum (Buschke-Loewenstein tumour) and verrucous squamous carcinoma of the perianal and anorectal region: a continuous precancerous spectrum?

Bogomoletz WV ，Potet F ，Molas G 《HISTOPATHOLOGY》

Perianal giant condyloma acuminatum (Buschke-Löwenstein tumor). Case report and review of the literature.

Papiu HS ，Dumnici A ，Olariu T ，Onita M ，Hornung E ，Goldis D ，Aiordachioae G ，Vasca V ... -  《Chirurgia》

[Perianal Buschke-Löwenstein tumour].

Uth Ovesen A 《-》

[Buschke-Loewenstein giant condyloma in the perianal region with inguinal invasion: a case report].

Ben Brahim E ，Chadli-Debbiche A ，Fraoua-Abdelmoula F ，Lahmar-Boufaroua A ，Bouchoucha S ，Khalfallah MT ，Mzabi-Regaya S ... -  《-》